Investigation of antiviral activity of adamantan boron derivaties on pandemic influenza virus models
Comparative investigation of the virus-inhibiting activity of some boron-containing compounds showed that products BG 12 and BG 4 had the highest inhibitory effect on pandemic viruses. The minimum inhibitory concentration (MIC) of the products was 0.1 mcg/ml. The use of liposomes loaded with BG 12 m...
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| Veröffentlicht in: | Antibiotiki i himioterapiâ 2011, Vol.56 (5-6), p.3-6 |
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| container_issue | 5-6 |
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| container_title | Antibiotiki i himioterapiâ |
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| creator | Markushin, S G Kantarov, N A Artiushenko, S V Akopova, I I Koptiaeva, I B Bubnov, Iu N |
| description | Comparative investigation of the virus-inhibiting activity of some boron-containing compounds showed that products BG 12 and BG 4 had the highest inhibitory effect on pandemic viruses. The minimum inhibitory concentration (MIC) of the products was 0.1 mcg/ml. The use of liposomes loaded with BG 12 molecules in the optimal concentration (0.1 mcg/ml) resulted in inhibition of the avian plague virus growth in the MDCK cells. Possible design of efficient drugs for antiviral protection based on the complexes liposomes--boron-containing compounds is discussed. |
| format | Article |
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Possible design of efficient drugs for antiviral protection based on the complexes liposomes--boron-containing compounds is discussed.</description><subject>Adamantane - analogs & derivatives</subject><subject>Adamantane - pharmacology</subject><subject>Animals</subject><subject>Antiviral Agents - chemistry</subject><subject>Antiviral Agents - pharmacology</subject><subject>Birds</subject><subject>Boron - chemistry</subject><subject>Boron - pharmacology</subject><subject>Cell Line</subject><subject>Chick Embryo</subject><subject>Dogs</subject><subject>Influenza A Virus, H7N7 Subtype - drug effects</subject><subject>Influenza in Birds - drug therapy</subject><subject>Influenza in Birds - virology</subject><subject>Liposomes - chemistry</subject><subject>Liposomes - pharmacology</subject><subject>Virus Replication - drug effects</subject><issn>0235-2990</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMtqwzAQRbVoaUKaXyjadWXQw7KiZQl9BALZZG_G0qio2LJr2Yb066u26Wpm7py5cOeGrJmQqhDGsBXZpvTBGJOSS8nYHVkJwUslRLkm7hAXTFN4hyn0kfaeQpzCEkZoKdifbrr8qg66vIFIm37MoMMxLPkGE83TANFhFywN0bczxi-g2WJOtOsdtume3HpoE26vdUPOL8_n_VtxPL0e9k_HYlCqLLTWzjLUmpkKpXLMIhegbdP40lUefA7U8MbgziH3lQVvdppVmjnpkXMvN-Txz3YY-885p6q7kCy2LUTs51QbZrQSplKZfLiSc9Ohq4cxdDBe6v-_yG8UuWE-</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Markushin, S G</creator><creator>Kantarov, N A</creator><creator>Artiushenko, S V</creator><creator>Akopova, I I</creator><creator>Koptiaeva, I B</creator><creator>Bubnov, Iu N</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2011</creationdate><title>Investigation of antiviral activity of adamantan boron derivaties on pandemic influenza virus models</title><author>Markushin, S G ; Kantarov, N A ; Artiushenko, S V ; Akopova, I I ; Koptiaeva, I B ; Bubnov, Iu N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p554-777dc0e77096e35d0ce12a7cbbf4d6faf235b1b9e8de1f6caf9870670d3fe11f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>rus</language><creationdate>2011</creationdate><topic>Adamantane - analogs & derivatives</topic><topic>Adamantane - pharmacology</topic><topic>Animals</topic><topic>Antiviral Agents - chemistry</topic><topic>Antiviral Agents - pharmacology</topic><topic>Birds</topic><topic>Boron - chemistry</topic><topic>Boron - pharmacology</topic><topic>Cell Line</topic><topic>Chick Embryo</topic><topic>Dogs</topic><topic>Influenza A Virus, H7N7 Subtype - drug effects</topic><topic>Influenza in Birds - drug therapy</topic><topic>Influenza in Birds - virology</topic><topic>Liposomes - chemistry</topic><topic>Liposomes - pharmacology</topic><topic>Virus Replication - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Markushin, S G</creatorcontrib><creatorcontrib>Kantarov, N A</creatorcontrib><creatorcontrib>Artiushenko, S V</creatorcontrib><creatorcontrib>Akopova, I I</creatorcontrib><creatorcontrib>Koptiaeva, I B</creatorcontrib><creatorcontrib>Bubnov, Iu N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Antibiotiki i himioterapiâ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Markushin, S G</au><au>Kantarov, N A</au><au>Artiushenko, S V</au><au>Akopova, I I</au><au>Koptiaeva, I B</au><au>Bubnov, Iu N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of antiviral activity of adamantan boron derivaties on pandemic influenza virus models</atitle><jtitle>Antibiotiki i himioterapiâ</jtitle><addtitle>Antibiot Khimioter</addtitle><date>2011</date><risdate>2011</risdate><volume>56</volume><issue>5-6</issue><spage>3</spage><epage>6</epage><pages>3-6</pages><issn>0235-2990</issn><abstract>Comparative investigation of the virus-inhibiting activity of some boron-containing compounds showed that products BG 12 and BG 4 had the highest inhibitory effect on pandemic viruses. 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| ispartof | Antibiotiki i himioterapiâ, 2011, Vol.56 (5-6), p.3-6 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals |
| subjects | Adamantane - analogs & derivatives Adamantane - pharmacology Animals Antiviral Agents - chemistry Antiviral Agents - pharmacology Birds Boron - chemistry Boron - pharmacology Cell Line Chick Embryo Dogs Influenza A Virus, H7N7 Subtype - drug effects Influenza in Birds - drug therapy Influenza in Birds - virology Liposomes - chemistry Liposomes - pharmacology Virus Replication - drug effects |
| title | Investigation of antiviral activity of adamantan boron derivaties on pandemic influenza virus models |
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