Effect of estrogen replacement therapy on symptoms of depression and anxiety in non-depressive menopausal women: A randomized double-blind, controlled study
The efficacy of estrogen replacement therapy (ERT) for mood disturbances associated with menopause has yet to be firmly established. The objective of this study was to investigate the efficacy of ERT for improving mood and anxiety of non-depressive postmenopausal women. This double-blind, randomized...
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| Veröffentlicht in: | Archives of women's mental health 2011-12, Vol.14 (6), p.479-486 |
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| creator | Demetrio, Frederico Navas Rennó, Joel Gianfaldoni, Arlete Gonçalves, Marcelo Halbe, Hans Wolfgang Filho, Antônio Hélio Guerra V. Gorenstein, Clarice |
| description | The efficacy of estrogen replacement therapy (ERT) for mood disturbances associated with menopause has yet to be firmly established. The objective of this study was to investigate the efficacy of ERT for improving mood and anxiety of non-depressive postmenopausal women. This double-blind, randomized, placebo-controlled study involved two treatment groups: one receiving conjugated equine estrogens (CEEs; 0.625 mg/day) and the other placebo, for six cycles of 28 days each. Subjects were hysterectomized, healthy, non-depressive (according to Schedule for Affective Disorders and Schizophrenia, Life Time Version [SADS-L]) women. Depressive and anxiety symptoms were assessed with the Beck Depression Inventory (BDI), and the Hamilton Anxiety Scale (HAMA), respectively. The Profile of Mood States (POMS) and other scales were used to characterize symptoms. In both groups, BDI scores were significantly lower at cycles 1, 2, 3, and 6, compared with baseline assessments (
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| doi_str_mv | 10.1007/s00737-011-0241-3 |
| format | Article |
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p
< 0.01). Anxiety scores for both groups significantly improved from cycle 3 to study endpoint. The only significant difference favoring the active group occurred at cycle 1. POMS scores were significantly improved at the end of cycles 1, 2, 3 and 6 among treated subjects and at the end of cycles 2, 3, and 6 among placebo subjects. ERT is not associated with improvements in mood or anxiety symptoms in non-depressive, hysterectomized, postmenopausal women.</description><identifier>ISSN: 1434-1816</identifier><identifier>EISSN: 1435-1102</identifier><identifier>DOI: 10.1007/s00737-011-0241-3</identifier><identifier>PMID: 22016254</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Adult ; Depression - prevention & control ; Depression, Mental ; Dose-Response Relationship, Drug ; Double-Blind Method ; Estradiol - administration & dosage ; Estrogen ; Estrogen Replacement Therapy - methods ; Female ; Health Status ; Hormone therapy ; Humans ; Hysterectomy ; Medicine ; Medicine & Public Health ; Menopause ; Menopause - psychology ; Middle Aged ; Original Article ; Phenols ; Placebo Effect ; Postmenopausal women ; Psychiatry ; Psychological aspects ; Psychotherapy ; Quality of Life ; Women's Health</subject><ispartof>Archives of women's mental health, 2011-12, Vol.14 (6), p.479-486</ispartof><rights>Springer-Verlag 2011</rights><rights>COPYRIGHT 2011 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3423-eeacb605cde1026dd308fdcff377058e6fb8d5431e3b6a842bf87a61f517ef153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00737-011-0241-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00737-011-0241-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22016254$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Demetrio, Frederico Navas</creatorcontrib><creatorcontrib>Rennó, Joel</creatorcontrib><creatorcontrib>Gianfaldoni, Arlete</creatorcontrib><creatorcontrib>Gonçalves, Marcelo</creatorcontrib><creatorcontrib>Halbe, Hans Wolfgang</creatorcontrib><creatorcontrib>Filho, Antônio Hélio Guerra V.</creatorcontrib><creatorcontrib>Gorenstein, Clarice</creatorcontrib><title>Effect of estrogen replacement therapy on symptoms of depression and anxiety in non-depressive menopausal women: A randomized double-blind, controlled study</title><title>Archives of women's mental health</title><addtitle>Arch Womens Ment Health</addtitle><addtitle>Arch Womens Ment Health</addtitle><description>The efficacy of estrogen replacement therapy (ERT) for mood disturbances associated with menopause has yet to be firmly established. The objective of this study was to investigate the efficacy of ERT for improving mood and anxiety of non-depressive postmenopausal women. This double-blind, randomized, placebo-controlled study involved two treatment groups: one receiving conjugated equine estrogens (CEEs; 0.625 mg/day) and the other placebo, for six cycles of 28 days each. Subjects were hysterectomized, healthy, non-depressive (according to Schedule for Affective Disorders and Schizophrenia, Life Time Version [SADS-L]) women. Depressive and anxiety symptoms were assessed with the Beck Depression Inventory (BDI), and the Hamilton Anxiety Scale (HAMA), respectively. The Profile of Mood States (POMS) and other scales were used to characterize symptoms. In both groups, BDI scores were significantly lower at cycles 1, 2, 3, and 6, compared with baseline assessments (
p
< 0.01). Anxiety scores for both groups significantly improved from cycle 3 to study endpoint. The only significant difference favoring the active group occurred at cycle 1. POMS scores were significantly improved at the end of cycles 1, 2, 3 and 6 among treated subjects and at the end of cycles 2, 3, and 6 among placebo subjects. ERT is not associated with improvements in mood or anxiety symptoms in non-depressive, hysterectomized, postmenopausal women.</description><subject>Adult</subject><subject>Depression - prevention & control</subject><subject>Depression, Mental</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Estradiol - administration & dosage</subject><subject>Estrogen</subject><subject>Estrogen Replacement Therapy - methods</subject><subject>Female</subject><subject>Health Status</subject><subject>Hormone therapy</subject><subject>Humans</subject><subject>Hysterectomy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Menopause</subject><subject>Menopause - psychology</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Phenols</subject><subject>Placebo Effect</subject><subject>Postmenopausal women</subject><subject>Psychiatry</subject><subject>Psychological aspects</subject><subject>Psychotherapy</subject><subject>Quality of Life</subject><subject>Women's Health</subject><issn>1434-1816</issn><issn>1435-1102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kl1rFTEQhhdRbK3-AG8kIChebM1s9iPnspTaFgqCH9chm52cs2U3WZNs7fn3zrqteEAkJJPMPDMwkzfLXgM_Bc6bj5EO0eQcIOdFCbl4kh1DKaocgBdPf9_LHCTUR9mLGG8559VmUz7PjoqCQ11U5XHmL6xFk5i3DGMKfouOBZwGbXBEl1jaYdDTnnnH4n6ckh_jwnY4BYyxJ7d2He37HtOe9Y457_LH6B0yKuInPUc9sJ-eHi-zZ1YPEV892JPs-6eLb-dX-c3ny-vzs5vciLIQOaI2bc0r0yG1Uned4NJ2xlrRNLySWNtWdlUpAEVba1kWrZWNrsFW0KCFSpxk79e6U_A_ZmpNjX00OAzaoZ-j2vBNQ6wURL5dya0eUPXO-hS0WWh1JkqAQtYgiTr9B0Wrw7E33qHtyX-Q8OEggZiE92lLs4jq-uuXQ_bdX-wO9ZB20Q9zovnGQxBW0AQfY0CrptCPOuwVcLVIQq2SUCQJtUhCLf29eZjE3I7Y_cl41AABxQpECrktBnXr5-Dod_5T9RdrRMAl</recordid><startdate>201112</startdate><enddate>201112</enddate><creator>Demetrio, Frederico Navas</creator><creator>Rennó, Joel</creator><creator>Gianfaldoni, Arlete</creator><creator>Gonçalves, Marcelo</creator><creator>Halbe, Hans Wolfgang</creator><creator>Filho, Antônio Hélio Guerra V.</creator><creator>Gorenstein, Clarice</creator><general>Springer Vienna</general><general>Springer</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>7X8</scope></search><sort><creationdate>201112</creationdate><title>Effect of estrogen replacement therapy on symptoms of depression and anxiety in non-depressive menopausal women</title><author>Demetrio, Frederico Navas ; Rennó, Joel ; Gianfaldoni, Arlete ; Gonçalves, Marcelo ; Halbe, Hans Wolfgang ; Filho, Antônio Hélio Guerra V. ; Gorenstein, Clarice</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3423-eeacb605cde1026dd308fdcff377058e6fb8d5431e3b6a842bf87a61f517ef153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Depression - prevention & control</topic><topic>Depression, Mental</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Estradiol - administration & dosage</topic><topic>Estrogen</topic><topic>Estrogen Replacement Therapy - methods</topic><topic>Female</topic><topic>Health Status</topic><topic>Hormone therapy</topic><topic>Humans</topic><topic>Hysterectomy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Menopause</topic><topic>Menopause - psychology</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Phenols</topic><topic>Placebo Effect</topic><topic>Postmenopausal women</topic><topic>Psychiatry</topic><topic>Psychological aspects</topic><topic>Psychotherapy</topic><topic>Quality of Life</topic><topic>Women's Health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Demetrio, Frederico Navas</creatorcontrib><creatorcontrib>Rennó, Joel</creatorcontrib><creatorcontrib>Gianfaldoni, Arlete</creatorcontrib><creatorcontrib>Gonçalves, Marcelo</creatorcontrib><creatorcontrib>Halbe, Hans Wolfgang</creatorcontrib><creatorcontrib>Filho, Antônio Hélio Guerra V.</creatorcontrib><creatorcontrib>Gorenstein, Clarice</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of women's mental health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Demetrio, Frederico Navas</au><au>Rennó, Joel</au><au>Gianfaldoni, Arlete</au><au>Gonçalves, Marcelo</au><au>Halbe, Hans Wolfgang</au><au>Filho, Antônio Hélio Guerra V.</au><au>Gorenstein, Clarice</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of estrogen replacement therapy on symptoms of depression and anxiety in non-depressive menopausal women: A randomized double-blind, controlled study</atitle><jtitle>Archives of women's mental health</jtitle><stitle>Arch Womens Ment Health</stitle><addtitle>Arch Womens Ment Health</addtitle><date>2011-12</date><risdate>2011</risdate><volume>14</volume><issue>6</issue><spage>479</spage><epage>486</epage><pages>479-486</pages><issn>1434-1816</issn><eissn>1435-1102</eissn><abstract>The efficacy of estrogen replacement therapy (ERT) for mood disturbances associated with menopause has yet to be firmly established. The objective of this study was to investigate the efficacy of ERT for improving mood and anxiety of non-depressive postmenopausal women. This double-blind, randomized, placebo-controlled study involved two treatment groups: one receiving conjugated equine estrogens (CEEs; 0.625 mg/day) and the other placebo, for six cycles of 28 days each. Subjects were hysterectomized, healthy, non-depressive (according to Schedule for Affective Disorders and Schizophrenia, Life Time Version [SADS-L]) women. Depressive and anxiety symptoms were assessed with the Beck Depression Inventory (BDI), and the Hamilton Anxiety Scale (HAMA), respectively. The Profile of Mood States (POMS) and other scales were used to characterize symptoms. In both groups, BDI scores were significantly lower at cycles 1, 2, 3, and 6, compared with baseline assessments (
p
< 0.01). Anxiety scores for both groups significantly improved from cycle 3 to study endpoint. The only significant difference favoring the active group occurred at cycle 1. POMS scores were significantly improved at the end of cycles 1, 2, 3 and 6 among treated subjects and at the end of cycles 2, 3, and 6 among placebo subjects. ERT is not associated with improvements in mood or anxiety symptoms in non-depressive, hysterectomized, postmenopausal women.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>22016254</pmid><doi>10.1007/s00737-011-0241-3</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Depression - prevention & control Depression, Mental Dose-Response Relationship, Drug Double-Blind Method Estradiol - administration & dosage Estrogen Estrogen Replacement Therapy - methods Female Health Status Hormone therapy Humans Hysterectomy Medicine Medicine & Public Health Menopause Menopause - psychology Middle Aged Original Article Phenols Placebo Effect Postmenopausal women Psychiatry Psychological aspects Psychotherapy Quality of Life Women's Health |
| title | Effect of estrogen replacement therapy on symptoms of depression and anxiety in non-depressive menopausal women: A randomized double-blind, controlled study |
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