Multivariate analyses of factors that affect neonatal screening thyroid stimulating hormone
Aims: All screening programmes in the UK use a primary thyroid stimulating hormone (TSH) screen for congenital hypothyroidism. Recent attention has been paid to aspects of screening, such as the relation between blood spot TSH levels and birth weight or gestational age. The aim of our study was to d...
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| Veröffentlicht in: | Journal of Pediatric Endocrinology and Metabolism 2011-10, Vol.24 (9-10), p.727-732 |
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| container_issue | 9-10 |
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| container_title | Journal of Pediatric Endocrinology and Metabolism |
| container_volume | 24 |
| creator | Ng, Sze May Wong, Sze Choong Paize, Fauzia Chakkarapani, Elavazhagan Newland, Paul Isherwood, David Didi, Mohammed |
| description | Aims: All screening programmes in the UK use a primary thyroid stimulating hormone (TSH) screen for congenital hypothyroidism. Recent attention has been paid to aspects of screening, such as the relation between blood spot TSH levels and birth weight or gestational age. The aim of our study was to determine the factors affecting screening neonatal TSH levels. Methods: We conducted a retrospective analysis of blood spot screening TSH levels of all infants screened at a single regional screening laboratory. Results: There were 6498 infants screened during a 12-week period. Screening TSH level showed negative correlation with gestational age and birth weight. Multiple linear regression analysis revealed low birth weight as the only independent factor affecting screening TSH level. Conclusions: Low birth weight infants appear to be at risk of thyroidal dysfunction. Our study showed that there were clinically significant but weak correlation between higher screening TSH levels and low birth weight. The clinical importance of these findings requires larger prospective studies to further elucidate the relevance of these factors affecting TSH screening levels. |
| doi_str_mv | 10.1515/JPEM.2011.234 |
| format | Article |
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Recent attention has been paid to aspects of screening, such as the relation between blood spot TSH levels and birth weight or gestational age. The aim of our study was to determine the factors affecting screening neonatal TSH levels. Methods: We conducted a retrospective analysis of blood spot screening TSH levels of all infants screened at a single regional screening laboratory. Results: There were 6498 infants screened during a 12-week period. Screening TSH level showed negative correlation with gestational age and birth weight. Multiple linear regression analysis revealed low birth weight as the only independent factor affecting screening TSH level. Conclusions: Low birth weight infants appear to be at risk of thyroidal dysfunction. Our study showed that there were clinically significant but weak correlation between higher screening TSH levels and low birth weight. The clinical importance of these findings requires larger prospective studies to further elucidate the relevance of these factors affecting TSH screening levels.</description><identifier>ISSN: 0334-018X</identifier><identifier>EISSN: 2191-0251</identifier><identifier>DOI: 10.1515/JPEM.2011.234</identifier><identifier>PMID: 22145464</identifier><language>eng</language><publisher>Germany: Walter de Gruyter</publisher><subject>Birth Weight ; congenital hypothyroidism ; Congenital Hypothyroidism - blood ; Congenital Hypothyroidism - diagnosis ; Congenital Hypothyroidism - epidemiology ; Dried Blood Spot Testing - methods ; Dried Blood Spot Testing - standards ; Female ; gestation ; Gestational Age ; Humans ; Infant, Newborn ; Male ; Multivariate Analysis ; Neonatal Screening - methods ; Neonatal Screening - standards ; Prevalence ; Reproducibility of Results ; Retrospective Studies ; Risk Factors ; screening ; thyroid stimulating hormone (TSH) ; Thyrotropin - blood</subject><ispartof>Journal of Pediatric Endocrinology and Metabolism, 2011-10, Vol.24 (9-10), p.727-732</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c330t-a95516db3880775ebad8483846c4c6d1897e2b8e0399fc3eabdb6d4b7c9b40a33</citedby><cites>FETCH-LOGICAL-c330t-a95516db3880775ebad8483846c4c6d1897e2b8e0399fc3eabdb6d4b7c9b40a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22145464$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ng, Sze May</creatorcontrib><creatorcontrib>Wong, Sze Choong</creatorcontrib><creatorcontrib>Paize, Fauzia</creatorcontrib><creatorcontrib>Chakkarapani, Elavazhagan</creatorcontrib><creatorcontrib>Newland, Paul</creatorcontrib><creatorcontrib>Isherwood, David</creatorcontrib><creatorcontrib>Didi, Mohammed</creatorcontrib><title>Multivariate analyses of factors that affect neonatal screening thyroid stimulating hormone</title><title>Journal of Pediatric Endocrinology and Metabolism</title><addtitle>Journal of Pediatric Endocrinology and Metabolism</addtitle><description>Aims: All screening programmes in the UK use a primary thyroid stimulating hormone (TSH) screen for congenital hypothyroidism. Recent attention has been paid to aspects of screening, such as the relation between blood spot TSH levels and birth weight or gestational age. The aim of our study was to determine the factors affecting screening neonatal TSH levels. Methods: We conducted a retrospective analysis of blood spot screening TSH levels of all infants screened at a single regional screening laboratory. Results: There were 6498 infants screened during a 12-week period. Screening TSH level showed negative correlation with gestational age and birth weight. Multiple linear regression analysis revealed low birth weight as the only independent factor affecting screening TSH level. Conclusions: Low birth weight infants appear to be at risk of thyroidal dysfunction. Our study showed that there were clinically significant but weak correlation between higher screening TSH levels and low birth weight. The clinical importance of these findings requires larger prospective studies to further elucidate the relevance of these factors affecting TSH screening levels.</description><subject>Birth Weight</subject><subject>congenital hypothyroidism</subject><subject>Congenital Hypothyroidism - blood</subject><subject>Congenital Hypothyroidism - diagnosis</subject><subject>Congenital Hypothyroidism - epidemiology</subject><subject>Dried Blood Spot Testing - methods</subject><subject>Dried Blood Spot Testing - standards</subject><subject>Female</subject><subject>gestation</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Multivariate Analysis</subject><subject>Neonatal Screening - methods</subject><subject>Neonatal Screening - standards</subject><subject>Prevalence</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>screening</subject><subject>thyroid stimulating hormone (TSH)</subject><subject>Thyrotropin - blood</subject><issn>0334-018X</issn><issn>2191-0251</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkElPwzAQhS0EohVw5Ipy45Tiie0sR4Qoi1oWARKCgzVxJhDIUmwH0X9PqrKcRnrv09PoY2wf-AQUqKPLm9P5JOIAk0jIDTaOIIOQRwo22ZgLIUMO6eOI7Tn3xjkHDgKU2GajKAKpZCzH7Hne1776RFuhpwBbrJeOXNCVQYnGd9YF_hV9gGVJxgctdS16rANnLFFbtS9DvbRdVQTOV01fo19lr51tupZ22VaJtaO9n7vDHqan9yfn4ez67OLkeBYaIbgPMVMK4iIXacqTRFGORSpTkcrYSBMXkGYJRXlKXGRZaQRhXuRxIfPEZLnkKMQOO1zvLmz30ZPzuqmcobrG4d_e6YxniQKI4oEM16SxnXOWSr2wVYN2qYHrlVG9MqpXRvVgdOAPfpb7vKHij_719z9YOU9ffz3adx0nIlH69l5q-TSd3j3KK83FN8ojgYg</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Ng, Sze May</creator><creator>Wong, Sze Choong</creator><creator>Paize, Fauzia</creator><creator>Chakkarapani, Elavazhagan</creator><creator>Newland, Paul</creator><creator>Isherwood, David</creator><creator>Didi, Mohammed</creator><general>Walter de Gruyter</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111001</creationdate><title>Multivariate analyses of factors that affect neonatal screening thyroid stimulating hormone</title><author>Ng, Sze May ; Wong, Sze Choong ; Paize, Fauzia ; Chakkarapani, Elavazhagan ; Newland, Paul ; Isherwood, David ; Didi, Mohammed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c330t-a95516db3880775ebad8483846c4c6d1897e2b8e0399fc3eabdb6d4b7c9b40a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Birth Weight</topic><topic>congenital hypothyroidism</topic><topic>Congenital Hypothyroidism - blood</topic><topic>Congenital Hypothyroidism - diagnosis</topic><topic>Congenital Hypothyroidism - epidemiology</topic><topic>Dried Blood Spot Testing - methods</topic><topic>Dried Blood Spot Testing - standards</topic><topic>Female</topic><topic>gestation</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Multivariate Analysis</topic><topic>Neonatal Screening - methods</topic><topic>Neonatal Screening - standards</topic><topic>Prevalence</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>screening</topic><topic>thyroid stimulating hormone (TSH)</topic><topic>Thyrotropin - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ng, Sze May</creatorcontrib><creatorcontrib>Wong, Sze Choong</creatorcontrib><creatorcontrib>Paize, Fauzia</creatorcontrib><creatorcontrib>Chakkarapani, Elavazhagan</creatorcontrib><creatorcontrib>Newland, Paul</creatorcontrib><creatorcontrib>Isherwood, David</creatorcontrib><creatorcontrib>Didi, Mohammed</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Pediatric Endocrinology and Metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ng, Sze May</au><au>Wong, Sze Choong</au><au>Paize, Fauzia</au><au>Chakkarapani, Elavazhagan</au><au>Newland, Paul</au><au>Isherwood, David</au><au>Didi, Mohammed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multivariate analyses of factors that affect neonatal screening thyroid stimulating hormone</atitle><jtitle>Journal of Pediatric Endocrinology and Metabolism</jtitle><addtitle>Journal of Pediatric Endocrinology and Metabolism</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>24</volume><issue>9-10</issue><spage>727</spage><epage>732</epage><pages>727-732</pages><issn>0334-018X</issn><eissn>2191-0251</eissn><abstract>Aims: All screening programmes in the UK use a primary thyroid stimulating hormone (TSH) screen for congenital hypothyroidism. Recent attention has been paid to aspects of screening, such as the relation between blood spot TSH levels and birth weight or gestational age. The aim of our study was to determine the factors affecting screening neonatal TSH levels. Methods: We conducted a retrospective analysis of blood spot screening TSH levels of all infants screened at a single regional screening laboratory. Results: There were 6498 infants screened during a 12-week period. Screening TSH level showed negative correlation with gestational age and birth weight. Multiple linear regression analysis revealed low birth weight as the only independent factor affecting screening TSH level. Conclusions: Low birth weight infants appear to be at risk of thyroidal dysfunction. Our study showed that there were clinically significant but weak correlation between higher screening TSH levels and low birth weight. The clinical importance of these findings requires larger prospective studies to further elucidate the relevance of these factors affecting TSH screening levels.</abstract><cop>Germany</cop><pub>Walter de Gruyter</pub><pmid>22145464</pmid><doi>10.1515/JPEM.2011.234</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0334-018X |
| ispartof | Journal of Pediatric Endocrinology and Metabolism, 2011-10, Vol.24 (9-10), p.727-732 |
| issn | 0334-018X 2191-0251 |
| language | eng |
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| source | MEDLINE; De Gruyter journals |
| subjects | Birth Weight congenital hypothyroidism Congenital Hypothyroidism - blood Congenital Hypothyroidism - diagnosis Congenital Hypothyroidism - epidemiology Dried Blood Spot Testing - methods Dried Blood Spot Testing - standards Female gestation Gestational Age Humans Infant, Newborn Male Multivariate Analysis Neonatal Screening - methods Neonatal Screening - standards Prevalence Reproducibility of Results Retrospective Studies Risk Factors screening thyroid stimulating hormone (TSH) Thyrotropin - blood |
| title | Multivariate analyses of factors that affect neonatal screening thyroid stimulating hormone |
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