Are postoperative intravenous antibiotics necessary after bimaxillary orthognathic surgery? A prospective, randomized, double-blind, placebo-controlled clinical trial
Abstract Postoperative antibiotic prophylaxis is often administered intravenously, despite an increased morbidity rate compared with oral application. This study investigates whether a postoperative oral antibiotic regimen is as effective as incorporation of intravenous antibiotics after bimaxillary...
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| Veröffentlicht in: | International journal of oral and maxillofacial surgery 2011-12, Vol.40 (12), p.1363-1368 |
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| creator | Tan, S.K Lo, J Zwahlen, R.A |
| description | Abstract Postoperative antibiotic prophylaxis is often administered intravenously, despite an increased morbidity rate compared with oral application. This study investigates whether a postoperative oral antibiotic regimen is as effective as incorporation of intravenous antibiotics after bimaxillary orthognathic surgery. 42 patients who underwent bimaxillary orthognathic surgery between December 2008 and May 2010 were randomly allocated to 2 placebo-controlled postoperative antibiotic prophylaxis groups. Group 1 received oral amoxicillin 500 mg three times daily; group 2 received intravenous ampicillin 1 g four times daily, during the first two postoperative days. Both groups subsequently took oral amoxicillin for three more days. Clinically, the infection rate was assessed in both study groups for a period of 6 weeks after the surgery. 9 patients (21.4%) developed infection. No adverse drug event was detected. No significant difference ( p = 0.45) was detected in the infection rate between group 1 (3/21) and group 2 (6/21). Age, type of surgical procedures, duration of the operative procedure, surgical procedure-related events, blood loss, and blood transfusion were all found not related to infection ( p > 0.05). Administration of more cost-effective oral antibiotic prophylaxis, which causes less comorbidity, can be considered to be safe in bimaxillary orthognathic surgery with segmentalizations. |
| doi_str_mv | 10.1016/j.ijom.2011.07.903 |
| format | Article |
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A prospective, randomized, double-blind, placebo-controlled clinical trial</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Tan, S.K ; Lo, J ; Zwahlen, R.A</creator><creatorcontrib>Tan, S.K ; Lo, J ; Zwahlen, R.A</creatorcontrib><description>Abstract Postoperative antibiotic prophylaxis is often administered intravenously, despite an increased morbidity rate compared with oral application. This study investigates whether a postoperative oral antibiotic regimen is as effective as incorporation of intravenous antibiotics after bimaxillary orthognathic surgery. 42 patients who underwent bimaxillary orthognathic surgery between December 2008 and May 2010 were randomly allocated to 2 placebo-controlled postoperative antibiotic prophylaxis groups. Group 1 received oral amoxicillin 500 mg three times daily; group 2 received intravenous ampicillin 1 g four times daily, during the first two postoperative days. Both groups subsequently took oral amoxicillin for three more days. Clinically, the infection rate was assessed in both study groups for a period of 6 weeks after the surgery. 9 patients (21.4%) developed infection. No adverse drug event was detected. No significant difference ( p = 0.45) was detected in the infection rate between group 1 (3/21) and group 2 (6/21). Age, type of surgical procedures, duration of the operative procedure, surgical procedure-related events, blood loss, and blood transfusion were all found not related to infection ( p > 0.05). Administration of more cost-effective oral antibiotic prophylaxis, which causes less comorbidity, can be considered to be safe in bimaxillary orthognathic surgery with segmentalizations.</description><identifier>ISSN: 0901-5027</identifier><identifier>EISSN: 1399-0020</identifier><identifier>DOI: 10.1016/j.ijom.2011.07.903</identifier><identifier>PMID: 21871782</identifier><identifier>CODEN: IJOSE9</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Administration, Oral ; Adolescent ; Adult ; adverse drug event ; Age Factors ; Amoxicillin - administration & dosage ; Ampicillin - administration & dosage ; Anti-Bacterial Agents - administration & dosage ; Antibacterial agents ; antibiotic ; Antibiotic Prophylaxis ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; antimicrobial agents ; bimaxillary osteotomies ; Biological and medical sciences ; Blood Loss, Surgical ; Blood Transfusion ; Dentistry ; Double-Blind Method ; Female ; Follow-Up Studies ; Humans ; infection ; Injections, Intravenous ; Male ; Mandible - surgery ; Maxilla - surgery ; Medical sciences ; Orthognathic Surgical Procedures - classification ; Orthognathic Surgical Procedures - methods ; Orthopedic surgery ; Otorhinolaryngology. Stomatology ; Pharmacology. Drug treatments ; Placebos ; Postoperative Care ; Postoperative Complications ; Prospective Studies ; Safety ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgical Wound Infection - etiology ; Time Factors ; Treatment Outcome ; Young Adult</subject><ispartof>International journal of oral and maxillofacial surgery, 2011-12, Vol.40 (12), p.1363-1368</ispartof><rights>International Association of Oral and Maxillofacial Surgeons</rights><rights>2011 International Association of Oral and Maxillofacial Surgeons</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-1dd19900a6a466620842d1ee70af8afa05a9c95d5aa29c92ee6d74b6b4b9a22b3</citedby><cites>FETCH-LOGICAL-c440t-1dd19900a6a466620842d1ee70af8afa05a9c95d5aa29c92ee6d74b6b4b9a22b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijom.2011.07.903$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25354282$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21871782$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, S.K</creatorcontrib><creatorcontrib>Lo, J</creatorcontrib><creatorcontrib>Zwahlen, R.A</creatorcontrib><title>Are postoperative intravenous antibiotics necessary after bimaxillary orthognathic surgery? A prospective, randomized, double-blind, placebo-controlled clinical trial</title><title>International journal of oral and maxillofacial surgery</title><addtitle>Int J Oral Maxillofac Surg</addtitle><description>Abstract Postoperative antibiotic prophylaxis is often administered intravenously, despite an increased morbidity rate compared with oral application. This study investigates whether a postoperative oral antibiotic regimen is as effective as incorporation of intravenous antibiotics after bimaxillary orthognathic surgery. 42 patients who underwent bimaxillary orthognathic surgery between December 2008 and May 2010 were randomly allocated to 2 placebo-controlled postoperative antibiotic prophylaxis groups. Group 1 received oral amoxicillin 500 mg three times daily; group 2 received intravenous ampicillin 1 g four times daily, during the first two postoperative days. Both groups subsequently took oral amoxicillin for three more days. Clinically, the infection rate was assessed in both study groups for a period of 6 weeks after the surgery. 9 patients (21.4%) developed infection. No adverse drug event was detected. No significant difference ( p = 0.45) was detected in the infection rate between group 1 (3/21) and group 2 (6/21). Age, type of surgical procedures, duration of the operative procedure, surgical procedure-related events, blood loss, and blood transfusion were all found not related to infection ( p > 0.05). Administration of more cost-effective oral antibiotic prophylaxis, which causes less comorbidity, can be considered to be safe in bimaxillary orthognathic surgery with segmentalizations.</description><subject>Administration, Oral</subject><subject>Adolescent</subject><subject>Adult</subject><subject>adverse drug event</subject><subject>Age Factors</subject><subject>Amoxicillin - administration & dosage</subject><subject>Ampicillin - administration & dosage</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Antibacterial agents</subject><subject>antibiotic</subject><subject>Antibiotic Prophylaxis</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>antimicrobial agents</subject><subject>bimaxillary osteotomies</subject><subject>Biological and medical sciences</subject><subject>Blood Loss, Surgical</subject><subject>Blood Transfusion</subject><subject>Dentistry</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>infection</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Mandible - surgery</subject><subject>Maxilla - surgery</subject><subject>Medical sciences</subject><subject>Orthognathic Surgical Procedures - classification</subject><subject>Orthognathic Surgical Procedures - methods</subject><subject>Orthopedic surgery</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Pharmacology. Drug treatments</subject><subject>Placebos</subject><subject>Postoperative Care</subject><subject>Postoperative Complications</subject><subject>Prospective Studies</subject><subject>Safety</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgical Wound Infection - etiology</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0901-5027</issn><issn>1399-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UsuO1DAQjBCIHRZ-gAPyBXHZDG3naQktGq14SStxAM5Wx-7sesjEwXZGDB_Ed-IwsyBx4ORXVbm7qrPsKYc1B16_3K7t1u3WAjhfQ7OWUNzLVryQMgcQcD9bgQSeVyCas-xRCFsAkEXbPMzOBG8b3rRilf3ceGKTC9FN5DHaPTE7Ro97Gt0cGI7RdtZFqwMbSVMI6A8M-0iedXaH3-0wLDfOx1t3M2K8tZqF2d-QP7xmGzZ5FybSi-4F8zgat7M_yFww4-ZuoLwb7JhO04CaOpdrl_52w0CG6fRiNQ4seovD4-xBj0OgJ6f1PPvy9s3nq_f59cd3H64217kuS4g5N4ZLCYA1lnVdC2hLYThRA9i32CNUKLWsTIUo0kYQ1aYpu7orO4lCdMV59uKomwr_NlOIameDptTkSMkPJUEKWZelSEhxROrUYvDUq8knQ_xBcVBLPGqrlnjUEo-CJlGLRHp2kp-7HZk_lLs8EuD5CYAhNd8ny7QNf3FVUZXiN-7VEUfJjL0lr4K2NGoy1ie7lXH2_3Vc_kO_s_srHShs3ezHZLPiKggF6tMySMsc8STIW8mLX2_WyEA</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Tan, S.K</creator><creator>Lo, J</creator><creator>Zwahlen, R.A</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111201</creationdate><title>Are postoperative intravenous antibiotics necessary after bimaxillary orthognathic surgery? A prospective, randomized, double-blind, placebo-controlled clinical trial</title><author>Tan, S.K ; Lo, J ; Zwahlen, R.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-1dd19900a6a466620842d1ee70af8afa05a9c95d5aa29c92ee6d74b6b4b9a22b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Administration, Oral</topic><topic>Adolescent</topic><topic>Adult</topic><topic>adverse drug event</topic><topic>Age Factors</topic><topic>Amoxicillin - administration & dosage</topic><topic>Ampicillin - administration & dosage</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Antibacterial agents</topic><topic>antibiotic</topic><topic>Antibiotic Prophylaxis</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>antimicrobial agents</topic><topic>bimaxillary osteotomies</topic><topic>Biological and medical sciences</topic><topic>Blood Loss, Surgical</topic><topic>Blood Transfusion</topic><topic>Dentistry</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>infection</topic><topic>Injections, Intravenous</topic><topic>Male</topic><topic>Mandible - surgery</topic><topic>Maxilla - surgery</topic><topic>Medical sciences</topic><topic>Orthognathic Surgical Procedures - classification</topic><topic>Orthognathic Surgical Procedures - methods</topic><topic>Orthopedic surgery</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Pharmacology. Drug treatments</topic><topic>Placebos</topic><topic>Postoperative Care</topic><topic>Postoperative Complications</topic><topic>Prospective Studies</topic><topic>Safety</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgical Wound Infection - etiology</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, S.K</creatorcontrib><creatorcontrib>Lo, J</creatorcontrib><creatorcontrib>Zwahlen, R.A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of oral and maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, S.K</au><au>Lo, J</au><au>Zwahlen, R.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Are postoperative intravenous antibiotics necessary after bimaxillary orthognathic surgery? A prospective, randomized, double-blind, placebo-controlled clinical trial</atitle><jtitle>International journal of oral and maxillofacial surgery</jtitle><addtitle>Int J Oral Maxillofac Surg</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>40</volume><issue>12</issue><spage>1363</spage><epage>1368</epage><pages>1363-1368</pages><issn>0901-5027</issn><eissn>1399-0020</eissn><coden>IJOSE9</coden><abstract>Abstract Postoperative antibiotic prophylaxis is often administered intravenously, despite an increased morbidity rate compared with oral application. This study investigates whether a postoperative oral antibiotic regimen is as effective as incorporation of intravenous antibiotics after bimaxillary orthognathic surgery. 42 patients who underwent bimaxillary orthognathic surgery between December 2008 and May 2010 were randomly allocated to 2 placebo-controlled postoperative antibiotic prophylaxis groups. Group 1 received oral amoxicillin 500 mg three times daily; group 2 received intravenous ampicillin 1 g four times daily, during the first two postoperative days. Both groups subsequently took oral amoxicillin for three more days. Clinically, the infection rate was assessed in both study groups for a period of 6 weeks after the surgery. 9 patients (21.4%) developed infection. No adverse drug event was detected. No significant difference ( p = 0.45) was detected in the infection rate between group 1 (3/21) and group 2 (6/21). Age, type of surgical procedures, duration of the operative procedure, surgical procedure-related events, blood loss, and blood transfusion were all found not related to infection ( p > 0.05). Administration of more cost-effective oral antibiotic prophylaxis, which causes less comorbidity, can be considered to be safe in bimaxillary orthognathic surgery with segmentalizations.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>21871782</pmid><doi>10.1016/j.ijom.2011.07.903</doi><tpages>6</tpages></addata></record> |
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| ispartof | International journal of oral and maxillofacial surgery, 2011-12, Vol.40 (12), p.1363-1368 |
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| subjects | Administration, Oral Adolescent Adult adverse drug event Age Factors Amoxicillin - administration & dosage Ampicillin - administration & dosage Anti-Bacterial Agents - administration & dosage Antibacterial agents antibiotic Antibiotic Prophylaxis Antibiotics. Antiinfectious agents. Antiparasitic agents antimicrobial agents bimaxillary osteotomies Biological and medical sciences Blood Loss, Surgical Blood Transfusion Dentistry Double-Blind Method Female Follow-Up Studies Humans infection Injections, Intravenous Male Mandible - surgery Maxilla - surgery Medical sciences Orthognathic Surgical Procedures - classification Orthognathic Surgical Procedures - methods Orthopedic surgery Otorhinolaryngology. Stomatology Pharmacology. Drug treatments Placebos Postoperative Care Postoperative Complications Prospective Studies Safety Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgical Wound Infection - etiology Time Factors Treatment Outcome Young Adult |
| title | Are postoperative intravenous antibiotics necessary after bimaxillary orthognathic surgery? A prospective, randomized, double-blind, placebo-controlled clinical trial |
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