Rotavirus vaccines: a long and difficult journey
Diarrhea is the second cause of death worldwide. The main causative agent in infants and children less than 5 years is rotavirus. Consequently, for the World Health Organization and the Global Alliance for Vaccines and Immunization (GAVI), rotavirus vaccination is an urgent priority. The global dist...
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| Veröffentlicht in: | Gastroenterología y hepatología 2011-12, Vol.34 (10), p.694-700 |
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| container_title | Gastroenterología y hepatología |
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| creator | Campins Martí, Magda Moraga-Llop, Fernando A |
| description | Diarrhea is the second cause of death worldwide. The main causative agent in infants and children less than 5 years is rotavirus. Consequently, for the World Health Organization and the Global Alliance for Vaccines and Immunization (GAVI), rotavirus vaccination is an urgent priority. The global distribution of rotavirus serotypes varies from country to country, but in 80-90% of cases is caused by five types: G1P[8], G2P[4], G3P[8], G4P[8] and G9P[8]. Currently, two rotavirus vaccines are available, an attenuated monovalent G1P[8] vaccine, and a pentavalent human-bovine recombinant vaccine containing five strains of bovine WC3 rotavirus, four with a gene codifying the VP7 protein of human rotaviruses G1, G2, G3 and G4, and a fifth expressing the VP4 P[8] genotype. |
| doi_str_mv | 10.1016/j.gastrohep.2011.09.003 |
| format | Article |
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Currently, two rotavirus vaccines are available, an attenuated monovalent G1P[8] vaccine, and a pentavalent human-bovine recombinant vaccine containing five strains of bovine WC3 rotavirus, four with a gene codifying the VP7 protein of human rotaviruses G1, G2, G3 and G4, and a fifth expressing the VP4 P[8] genotype.</description><identifier>ISSN: 0210-5705</identifier><identifier>DOI: 10.1016/j.gastrohep.2011.09.003</identifier><identifier>PMID: 22112634</identifier><language>spa</language><publisher>Spain</publisher><subject>Diarrhea - prevention & control ; Diarrhea - virology ; Humans ; Rotavirus Infections - prevention & control ; Rotavirus Vaccines - adverse effects ; Rotavirus Vaccines - immunology</subject><ispartof>Gastroenterología y hepatología, 2011-12, Vol.34 (10), p.694-700</ispartof><rights>Copyright © 2011 Elsevier España, S.L. 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Consequently, for the World Health Organization and the Global Alliance for Vaccines and Immunization (GAVI), rotavirus vaccination is an urgent priority. The global distribution of rotavirus serotypes varies from country to country, but in 80-90% of cases is caused by five types: G1P[8], G2P[4], G3P[8], G4P[8] and G9P[8]. 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| ispartof | Gastroenterología y hepatología, 2011-12, Vol.34 (10), p.694-700 |
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| language | spa |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Diarrhea - prevention & control Diarrhea - virology Humans Rotavirus Infections - prevention & control Rotavirus Vaccines - adverse effects Rotavirus Vaccines - immunology |
| title | Rotavirus vaccines: a long and difficult journey |
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