The α-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fat
Dietary intake of industrially hydrogenated trans fatty acids (TFA) has been associated with coronary heart disease. Dietary flaxseed can inhibit atherosclerosis induced by dietary cholesterol. The aim of this study was to determine whether supplementing the diet with flaxseed could protect against...
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| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 2011-12, Vol.301 (6), p.H2220-H2226 |
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| container_title | American journal of physiology. Heart and circulatory physiology |
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| creator | Bassett, Chantal M C McCullough, Richelle S Edel, Andrea L Patenaude, Amanda LaVallee, Renee K Pierce, Grant N |
| description | Dietary intake of industrially hydrogenated trans fatty acids (TFA) has been associated with coronary heart disease. Dietary flaxseed can inhibit atherosclerosis induced by dietary cholesterol. The aim of this study was to determine whether supplementing the diet with flaxseed could protect against atherosclerosis induced by a diet enriched in TFA. Low-density lipoprotein receptor-deficient (LDLr(-/-)) mice were fed 1 of 14 experimental diets for 14 wk containing one of two fat sources [regular (pork/soy) or trans fat] at two concentrations (4 or 8%) and supplemented with or without dietary cholesterol (2%), whole ground flaxseed, or one of the components of flaxseed [α-linolenic acid (ALA), defatted fiber, or lignan]. Adding flaxseed to the diet partially mitigated the rise in circulating cholesterol levels induced by the cholesterol-enriched diet. Atherosclerosis was stimulated by TFA and/or cholesterol. Including milled flaxseed to an atherogenic diet significantly reduced atherosclerosis compared with the groups that consumed cholesterol and/or TFA. ALA was the only component within flaxseed that could inhibit the atherogenic action of cholesterol and/or TFA on its own. Dietary flaxseed protects against atherosclerotic development induced by TFA and cholesterol feeding through its content of ALA. |
| doi_str_mv | 10.1152/ajpheart.00958.2010 |
| format | Article |
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Dietary flaxseed can inhibit atherosclerosis induced by dietary cholesterol. The aim of this study was to determine whether supplementing the diet with flaxseed could protect against atherosclerosis induced by a diet enriched in TFA. Low-density lipoprotein receptor-deficient (LDLr(-/-)) mice were fed 1 of 14 experimental diets for 14 wk containing one of two fat sources [regular (pork/soy) or trans fat] at two concentrations (4 or 8%) and supplemented with or without dietary cholesterol (2%), whole ground flaxseed, or one of the components of flaxseed [α-linolenic acid (ALA), defatted fiber, or lignan]. Adding flaxseed to the diet partially mitigated the rise in circulating cholesterol levels induced by the cholesterol-enriched diet. Atherosclerosis was stimulated by TFA and/or cholesterol. Including milled flaxseed to an atherogenic diet significantly reduced atherosclerosis compared with the groups that consumed cholesterol and/or TFA. ALA was the only component within flaxseed that could inhibit the atherogenic action of cholesterol and/or TFA on its own. Dietary flaxseed protects against atherosclerotic development induced by TFA and cholesterol feeding through its content of ALA.</description><identifier>ISSN: 0363-6135</identifier><identifier>EISSN: 1522-1539</identifier><identifier>DOI: 10.1152/ajpheart.00958.2010</identifier><identifier>PMID: 21963840</identifier><language>eng</language><publisher>United States</publisher><subject>alpha-Linolenic Acid - pharmacology ; Animals ; Aortic Diseases - blood ; Aortic Diseases - etiology ; Aortic Diseases - pathology ; Aortic Diseases - prevention & control ; Atherosclerosis - blood ; Atherosclerosis - etiology ; Atherosclerosis - pathology ; Atherosclerosis - prevention & control ; Cholesterol, Dietary - blood ; Dietary Fats, Unsaturated - blood ; Dietary Fiber - pharmacology ; Disease Models, Animal ; Female ; Flax ; Lignans - pharmacology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Plant Preparations - pharmacology ; Receptors, LDL - deficiency ; Receptors, LDL - genetics ; Seeds ; Time Factors ; Trans Fatty Acids - blood ; Triglycerides - blood</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 2011-12, Vol.301 (6), p.H2220-H2226</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c304t-fbe29c05700c95213940ddc1d619a36aa1e14499da699fb3ec145faceee1fffd3</citedby><cites>FETCH-LOGICAL-c304t-fbe29c05700c95213940ddc1d619a36aa1e14499da699fb3ec145faceee1fffd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21963840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bassett, Chantal M C</creatorcontrib><creatorcontrib>McCullough, Richelle S</creatorcontrib><creatorcontrib>Edel, Andrea L</creatorcontrib><creatorcontrib>Patenaude, Amanda</creatorcontrib><creatorcontrib>LaVallee, Renee K</creatorcontrib><creatorcontrib>Pierce, Grant N</creatorcontrib><title>The α-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fat</title><title>American journal of physiology. Heart and circulatory physiology</title><addtitle>Am J Physiol Heart Circ Physiol</addtitle><description>Dietary intake of industrially hydrogenated trans fatty acids (TFA) has been associated with coronary heart disease. Dietary flaxseed can inhibit atherosclerosis induced by dietary cholesterol. The aim of this study was to determine whether supplementing the diet with flaxseed could protect against atherosclerosis induced by a diet enriched in TFA. Low-density lipoprotein receptor-deficient (LDLr(-/-)) mice were fed 1 of 14 experimental diets for 14 wk containing one of two fat sources [regular (pork/soy) or trans fat] at two concentrations (4 or 8%) and supplemented with or without dietary cholesterol (2%), whole ground flaxseed, or one of the components of flaxseed [α-linolenic acid (ALA), defatted fiber, or lignan]. Adding flaxseed to the diet partially mitigated the rise in circulating cholesterol levels induced by the cholesterol-enriched diet. Atherosclerosis was stimulated by TFA and/or cholesterol. Including milled flaxseed to an atherogenic diet significantly reduced atherosclerosis compared with the groups that consumed cholesterol and/or TFA. ALA was the only component within flaxseed that could inhibit the atherogenic action of cholesterol and/or TFA on its own. Dietary flaxseed protects against atherosclerotic development induced by TFA and cholesterol feeding through its content of ALA.</description><subject>alpha-Linolenic Acid - pharmacology</subject><subject>Animals</subject><subject>Aortic Diseases - blood</subject><subject>Aortic Diseases - etiology</subject><subject>Aortic Diseases - pathology</subject><subject>Aortic Diseases - prevention & control</subject><subject>Atherosclerosis - blood</subject><subject>Atherosclerosis - etiology</subject><subject>Atherosclerosis - pathology</subject><subject>Atherosclerosis - prevention & control</subject><subject>Cholesterol, Dietary - blood</subject><subject>Dietary Fats, Unsaturated - blood</subject><subject>Dietary Fiber - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Flax</subject><subject>Lignans - pharmacology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Plant Preparations - pharmacology</subject><subject>Receptors, LDL - deficiency</subject><subject>Receptors, LDL - genetics</subject><subject>Seeds</subject><subject>Time Factors</subject><subject>Trans Fatty Acids - blood</subject><subject>Triglycerides - blood</subject><issn>0363-6135</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1OwzAQhS0EoqVwAiTkHasUO07SeIkq_qRKbMramthjmipNgu0iOBYX4Uw4_WEzI8289_T0EXLN2ZTzPL2Ddb9CcGHKmMzLaco4OyHj-EkTngt5SsZMFCIpuMhH5ML7NWMsnxXinIxSLgtRZmxMquUK6e9P0tRt12Bbawq6NlR3bcA20M5S28CXR4w3aGnv8HO4h-iCOFz3vjOhtaiDH_SmxgDumwYHracWwiU5s9B4vDrsCXl7fFjOn5PF69PL_H6RaMGykNgKU6ljQ8a0zFMuZMaM0dwUXIIoADjyLJPSQCGlrQRqnuUWNCJya60RE3K7z-1d97FFH9Sm9hqbBlrstl5JJtNSzkoZlWKv1K7z3qFVvas3sbTiTA1s1ZGt2rFVA9voujnkb6sNmn_PEab4AzBHeZs</recordid><startdate>201112</startdate><enddate>201112</enddate><creator>Bassett, Chantal M C</creator><creator>McCullough, Richelle S</creator><creator>Edel, Andrea L</creator><creator>Patenaude, Amanda</creator><creator>LaVallee, Renee K</creator><creator>Pierce, Grant N</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201112</creationdate><title>The α-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fat</title><author>Bassett, Chantal M C ; McCullough, Richelle S ; Edel, Andrea L ; Patenaude, Amanda ; LaVallee, Renee K ; Pierce, Grant N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c304t-fbe29c05700c95213940ddc1d619a36aa1e14499da699fb3ec145faceee1fffd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>alpha-Linolenic Acid - pharmacology</topic><topic>Animals</topic><topic>Aortic Diseases - blood</topic><topic>Aortic Diseases - etiology</topic><topic>Aortic Diseases - pathology</topic><topic>Aortic Diseases - prevention & control</topic><topic>Atherosclerosis - blood</topic><topic>Atherosclerosis - etiology</topic><topic>Atherosclerosis - pathology</topic><topic>Atherosclerosis - prevention & control</topic><topic>Cholesterol, Dietary - blood</topic><topic>Dietary Fats, Unsaturated - blood</topic><topic>Dietary Fiber - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Flax</topic><topic>Lignans - pharmacology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Plant Preparations - pharmacology</topic><topic>Receptors, LDL - deficiency</topic><topic>Receptors, LDL - genetics</topic><topic>Seeds</topic><topic>Time Factors</topic><topic>Trans Fatty Acids - blood</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bassett, Chantal M C</creatorcontrib><creatorcontrib>McCullough, Richelle S</creatorcontrib><creatorcontrib>Edel, Andrea L</creatorcontrib><creatorcontrib>Patenaude, Amanda</creatorcontrib><creatorcontrib>LaVallee, Renee K</creatorcontrib><creatorcontrib>Pierce, Grant N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bassett, Chantal M C</au><au>McCullough, Richelle S</au><au>Edel, Andrea L</au><au>Patenaude, Amanda</au><au>LaVallee, Renee K</au><au>Pierce, Grant N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The α-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fat</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><addtitle>Am J Physiol Heart Circ Physiol</addtitle><date>2011-12</date><risdate>2011</risdate><volume>301</volume><issue>6</issue><spage>H2220</spage><epage>H2226</epage><pages>H2220-H2226</pages><issn>0363-6135</issn><eissn>1522-1539</eissn><abstract>Dietary intake of industrially hydrogenated trans fatty acids (TFA) has been associated with coronary heart disease. Dietary flaxseed can inhibit atherosclerosis induced by dietary cholesterol. The aim of this study was to determine whether supplementing the diet with flaxseed could protect against atherosclerosis induced by a diet enriched in TFA. Low-density lipoprotein receptor-deficient (LDLr(-/-)) mice were fed 1 of 14 experimental diets for 14 wk containing one of two fat sources [regular (pork/soy) or trans fat] at two concentrations (4 or 8%) and supplemented with or without dietary cholesterol (2%), whole ground flaxseed, or one of the components of flaxseed [α-linolenic acid (ALA), defatted fiber, or lignan]. Adding flaxseed to the diet partially mitigated the rise in circulating cholesterol levels induced by the cholesterol-enriched diet. Atherosclerosis was stimulated by TFA and/or cholesterol. Including milled flaxseed to an atherogenic diet significantly reduced atherosclerosis compared with the groups that consumed cholesterol and/or TFA. ALA was the only component within flaxseed that could inhibit the atherogenic action of cholesterol and/or TFA on its own. Dietary flaxseed protects against atherosclerotic development induced by TFA and cholesterol feeding through its content of ALA.</abstract><cop>United States</cop><pmid>21963840</pmid><doi>10.1152/ajpheart.00958.2010</doi></addata></record> |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | alpha-Linolenic Acid - pharmacology Animals Aortic Diseases - blood Aortic Diseases - etiology Aortic Diseases - pathology Aortic Diseases - prevention & control Atherosclerosis - blood Atherosclerosis - etiology Atherosclerosis - pathology Atherosclerosis - prevention & control Cholesterol, Dietary - blood Dietary Fats, Unsaturated - blood Dietary Fiber - pharmacology Disease Models, Animal Female Flax Lignans - pharmacology Mice Mice, Inbred C57BL Mice, Knockout Plant Preparations - pharmacology Receptors, LDL - deficiency Receptors, LDL - genetics Seeds Time Factors Trans Fatty Acids - blood Triglycerides - blood |
| title | The α-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fat |
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