Beyond the metabolic role of ghrelin: A new player in the regulation of reproductive function
Ghrelin is a gastric peptide, discovered by Kojima et al. (1999) [55] as a result of the search for an endogenous ligand interacting with the “orphan receptor” GHS-R1a (growth hormone secretagogue receptor type 1a). Ghrelin is composed of 28 aminoacids and is produced mostly by specific cells of the...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2011-12, Vol.32 (12), p.2514-2521 |
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| creator | Muccioli, Giampiero Lorenzi, Teresa Lorenzi, Maria Ghè, Corrado Arnoletti, Elisa Raso, Giuseppina Mattace Castellucci, Mario Gualillo, Oreste Meli, Rosaria |
| description | Ghrelin is a gastric peptide, discovered by Kojima et al. (1999)
[55] as a result of the search for an endogenous ligand interacting with the “orphan receptor” GHS-R1a (growth hormone secretagogue receptor type 1a). Ghrelin is composed of 28 aminoacids and is produced mostly by specific cells of the stomach, by the hypothalamus and hypophysis, even if its presence, as well as that of its receptors, has been demonstrated in many other tissues, not least in gonads. Ghrelin potently stimulates GH release and participates in the regulation of energy homeostasis, increasing food intake, decreasing energy output and exerting a lipogenetic effect. Furthermore, ghrelin influences the secretion and motility of the gastrointestinal tract, especially of the stomach, and, above all, profoundly affects pancreatic functions. Despite of these previously envisaged activities, it has recently been hypothesized that ghrelin regulates several aspects of reproductive physiology and pathology. In conclusion, ghrelin not only cooperates with other neuroendocrine factors, such as leptin, in the modulation of energy homeostasis, but also has a crucial role in the regulation of the hypothalamic–pituitary gonadal axis. In the current review we summarize the main targets of this gastric peptide, especially focusing on the reproductive system. |
| doi_str_mv | 10.1016/j.peptides.2011.10.020 |
| format | Article |
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[55] as a result of the search for an endogenous ligand interacting with the “orphan receptor” GHS-R1a (growth hormone secretagogue receptor type 1a). Ghrelin is composed of 28 aminoacids and is produced mostly by specific cells of the stomach, by the hypothalamus and hypophysis, even if its presence, as well as that of its receptors, has been demonstrated in many other tissues, not least in gonads. Ghrelin potently stimulates GH release and participates in the regulation of energy homeostasis, increasing food intake, decreasing energy output and exerting a lipogenetic effect. Furthermore, ghrelin influences the secretion and motility of the gastrointestinal tract, especially of the stomach, and, above all, profoundly affects pancreatic functions. Despite of these previously envisaged activities, it has recently been hypothesized that ghrelin regulates several aspects of reproductive physiology and pathology. In conclusion, ghrelin not only cooperates with other neuroendocrine factors, such as leptin, in the modulation of energy homeostasis, but also has a crucial role in the regulation of the hypothalamic–pituitary gonadal axis. In the current review we summarize the main targets of this gastric peptide, especially focusing on the reproductive system.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/j.peptides.2011.10.020</identifier><identifier>PMID: 22074955</identifier><identifier>CODEN: PPTDD5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>aminoacids ; Animals ; Biological and medical sciences ; Control ; energy ; Energy homeostasis ; Energy Metabolism ; Female ; Focusing ; food intake ; Fundamental and applied biological sciences. Psychology ; gastrointestinal motility ; Ghrelin ; Ghrelin - blood ; Ghrelin - pharmacology ; Ghrelin - physiology ; ghrelin receptors ; Gonadotropins - secretion ; gonads ; Gonads - physiology ; Homeostasis ; Humans ; hypophysis ; Hypothalamo-Hypophyseal System - drug effects ; Hypothalamo-Hypophyseal System - physiology ; hypothalamus ; leptin ; Male ; Peptides ; Physiology ; pituitary gland ; Pituitary-Adrenal System - drug effects ; Pituitary-Adrenal System - physiology ; Pregnancy ; Puberty - drug effects ; Puberty - physiology ; Rats ; Receptors ; Receptors, Ghrelin - genetics ; Receptors, Ghrelin - physiology ; Reproduction ; reproductive physiology ; reproductive system ; Searching ; secretion ; Stomach ; tissues ; Vertebrates: endocrinology</subject><ispartof>Peptides (New York, N.Y. : 1980), 2011-12, Vol.32 (12), p.2514-2521</ispartof><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c553t-63f14c4a720c1dd9a8f8fd2f3d01b301fadcc38648dfa4c1d023d8187b15559a3</citedby><cites>FETCH-LOGICAL-c553t-63f14c4a720c1dd9a8f8fd2f3d01b301fadcc38648dfa4c1d023d8187b15559a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S019697811100427X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25867561$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22074955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muccioli, Giampiero</creatorcontrib><creatorcontrib>Lorenzi, Teresa</creatorcontrib><creatorcontrib>Lorenzi, Maria</creatorcontrib><creatorcontrib>Ghè, Corrado</creatorcontrib><creatorcontrib>Arnoletti, Elisa</creatorcontrib><creatorcontrib>Raso, Giuseppina Mattace</creatorcontrib><creatorcontrib>Castellucci, Mario</creatorcontrib><creatorcontrib>Gualillo, Oreste</creatorcontrib><creatorcontrib>Meli, Rosaria</creatorcontrib><title>Beyond the metabolic role of ghrelin: A new player in the regulation of reproductive function</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>Ghrelin is a gastric peptide, discovered by Kojima et al. (1999)
[55] as a result of the search for an endogenous ligand interacting with the “orphan receptor” GHS-R1a (growth hormone secretagogue receptor type 1a). Ghrelin is composed of 28 aminoacids and is produced mostly by specific cells of the stomach, by the hypothalamus and hypophysis, even if its presence, as well as that of its receptors, has been demonstrated in many other tissues, not least in gonads. Ghrelin potently stimulates GH release and participates in the regulation of energy homeostasis, increasing food intake, decreasing energy output and exerting a lipogenetic effect. Furthermore, ghrelin influences the secretion and motility of the gastrointestinal tract, especially of the stomach, and, above all, profoundly affects pancreatic functions. Despite of these previously envisaged activities, it has recently been hypothesized that ghrelin regulates several aspects of reproductive physiology and pathology. In conclusion, ghrelin not only cooperates with other neuroendocrine factors, such as leptin, in the modulation of energy homeostasis, but also has a crucial role in the regulation of the hypothalamic–pituitary gonadal axis. In the current review we summarize the main targets of this gastric peptide, especially focusing on the reproductive system.</description><subject>aminoacids</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Control</subject><subject>energy</subject><subject>Energy homeostasis</subject><subject>Energy Metabolism</subject><subject>Female</subject><subject>Focusing</subject><subject>food intake</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gastrointestinal motility</subject><subject>Ghrelin</subject><subject>Ghrelin - blood</subject><subject>Ghrelin - pharmacology</subject><subject>Ghrelin - physiology</subject><subject>ghrelin receptors</subject><subject>Gonadotropins - secretion</subject><subject>gonads</subject><subject>Gonads - physiology</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>hypophysis</subject><subject>Hypothalamo-Hypophyseal System - drug effects</subject><subject>Hypothalamo-Hypophyseal System - physiology</subject><subject>hypothalamus</subject><subject>leptin</subject><subject>Male</subject><subject>Peptides</subject><subject>Physiology</subject><subject>pituitary gland</subject><subject>Pituitary-Adrenal System - drug effects</subject><subject>Pituitary-Adrenal System - physiology</subject><subject>Pregnancy</subject><subject>Puberty - drug effects</subject><subject>Puberty - physiology</subject><subject>Rats</subject><subject>Receptors</subject><subject>Receptors, Ghrelin - genetics</subject><subject>Receptors, Ghrelin - physiology</subject><subject>Reproduction</subject><subject>reproductive physiology</subject><subject>reproductive system</subject><subject>Searching</subject><subject>secretion</subject><subject>Stomach</subject><subject>tissues</subject><subject>Vertebrates: endocrinology</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0ctu1DAUBmALUdFp4RWKN4huMvgSX8KqFwFFqsQCukSRxz6eepSJg50UzdvXYaawoytLx9-xj_0jdEbJkhIqP2yWAwxjcJCXjFBaikvCyAu0oFrxSlDZvEQLQhtZNUrTY3SS84YQUteNfoWOGSOqboRYoJ9XsIu9w-M94C2MZhW7YHGKHeDo8fo-QRf6j_gS9_AbD53ZQcKh_8MTrKfOjCH2M00wpOgmO4YHwH7q7bzxGh1502V4c1hP0d3nTz-ub6rbb1--Xl_eVlYIPlaSe1rb2ihGLHWuMdpr75jnjtAVJ9QbZy3XstbOm7oQwrjT5aUrKoRoDD9F7_fnlhl-TZDHdhuyha4zPcQptw3RquZSqiLP_yupkowyXb7peUoo0Q1X9UzlntoUc07g2yGFrUm7gmYn2037lFc75zXXS16l8exwx7Tagvvb9hRQAe8OwGRrOp9Mb0P-54SWSkha3Nu98ya2Zp2KuftebpIldE4UZUVc7AWUIB4CpDbbAL0FFxLYsXUxPDftIy51v7U</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Muccioli, Giampiero</creator><creator>Lorenzi, Teresa</creator><creator>Lorenzi, Maria</creator><creator>Ghè, Corrado</creator><creator>Arnoletti, Elisa</creator><creator>Raso, Giuseppina Mattace</creator><creator>Castellucci, Mario</creator><creator>Gualillo, Oreste</creator><creator>Meli, Rosaria</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20111201</creationdate><title>Beyond the metabolic role of ghrelin: A new player in the regulation of reproductive function</title><author>Muccioli, Giampiero ; Lorenzi, Teresa ; Lorenzi, Maria ; Ghè, Corrado ; Arnoletti, Elisa ; Raso, Giuseppina Mattace ; Castellucci, Mario ; Gualillo, Oreste ; Meli, Rosaria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c553t-63f14c4a720c1dd9a8f8fd2f3d01b301fadcc38648dfa4c1d023d8187b15559a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>aminoacids</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Control</topic><topic>energy</topic><topic>Energy homeostasis</topic><topic>Energy Metabolism</topic><topic>Female</topic><topic>Focusing</topic><topic>food intake</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gastrointestinal motility</topic><topic>Ghrelin</topic><topic>Ghrelin - blood</topic><topic>Ghrelin - pharmacology</topic><topic>Ghrelin - physiology</topic><topic>ghrelin receptors</topic><topic>Gonadotropins - secretion</topic><topic>gonads</topic><topic>Gonads - physiology</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>hypophysis</topic><topic>Hypothalamo-Hypophyseal System - drug effects</topic><topic>Hypothalamo-Hypophyseal System - physiology</topic><topic>hypothalamus</topic><topic>leptin</topic><topic>Male</topic><topic>Peptides</topic><topic>Physiology</topic><topic>pituitary gland</topic><topic>Pituitary-Adrenal System - drug effects</topic><topic>Pituitary-Adrenal System - physiology</topic><topic>Pregnancy</topic><topic>Puberty - drug effects</topic><topic>Puberty - physiology</topic><topic>Rats</topic><topic>Receptors</topic><topic>Receptors, Ghrelin - genetics</topic><topic>Receptors, Ghrelin - physiology</topic><topic>Reproduction</topic><topic>reproductive physiology</topic><topic>reproductive system</topic><topic>Searching</topic><topic>secretion</topic><topic>Stomach</topic><topic>tissues</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muccioli, Giampiero</creatorcontrib><creatorcontrib>Lorenzi, Teresa</creatorcontrib><creatorcontrib>Lorenzi, Maria</creatorcontrib><creatorcontrib>Ghè, Corrado</creatorcontrib><creatorcontrib>Arnoletti, Elisa</creatorcontrib><creatorcontrib>Raso, Giuseppina Mattace</creatorcontrib><creatorcontrib>Castellucci, Mario</creatorcontrib><creatorcontrib>Gualillo, Oreste</creatorcontrib><creatorcontrib>Meli, Rosaria</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muccioli, Giampiero</au><au>Lorenzi, Teresa</au><au>Lorenzi, Maria</au><au>Ghè, Corrado</au><au>Arnoletti, Elisa</au><au>Raso, Giuseppina Mattace</au><au>Castellucci, Mario</au><au>Gualillo, Oreste</au><au>Meli, Rosaria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beyond the metabolic role of ghrelin: A new player in the regulation of reproductive function</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>32</volume><issue>12</issue><spage>2514</spage><epage>2521</epage><pages>2514-2521</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><coden>PPTDD5</coden><abstract>Ghrelin is a gastric peptide, discovered by Kojima et al. 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[55] as a result of the search for an endogenous ligand interacting with the “orphan receptor” GHS-R1a (growth hormone secretagogue receptor type 1a). Ghrelin is composed of 28 aminoacids and is produced mostly by specific cells of the stomach, by the hypothalamus and hypophysis, even if its presence, as well as that of its receptors, has been demonstrated in many other tissues, not least in gonads. Ghrelin potently stimulates GH release and participates in the regulation of energy homeostasis, increasing food intake, decreasing energy output and exerting a lipogenetic effect. Furthermore, ghrelin influences the secretion and motility of the gastrointestinal tract, especially of the stomach, and, above all, profoundly affects pancreatic functions. Despite of these previously envisaged activities, it has recently been hypothesized that ghrelin regulates several aspects of reproductive physiology and pathology. In conclusion, ghrelin not only cooperates with other neuroendocrine factors, such as leptin, in the modulation of energy homeostasis, but also has a crucial role in the regulation of the hypothalamic–pituitary gonadal axis. In the current review we summarize the main targets of this gastric peptide, especially focusing on the reproductive system.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22074955</pmid><doi>10.1016/j.peptides.2011.10.020</doi><tpages>8</tpages></addata></record> |
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| ispartof | Peptides (New York, N.Y. : 1980), 2011-12, Vol.32 (12), p.2514-2521 |
| issn | 0196-9781 1873-5169 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | aminoacids Animals Biological and medical sciences Control energy Energy homeostasis Energy Metabolism Female Focusing food intake Fundamental and applied biological sciences. Psychology gastrointestinal motility Ghrelin Ghrelin - blood Ghrelin - pharmacology Ghrelin - physiology ghrelin receptors Gonadotropins - secretion gonads Gonads - physiology Homeostasis Humans hypophysis Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - physiology hypothalamus leptin Male Peptides Physiology pituitary gland Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - physiology Pregnancy Puberty - drug effects Puberty - physiology Rats Receptors Receptors, Ghrelin - genetics Receptors, Ghrelin - physiology Reproduction reproductive physiology reproductive system Searching secretion Stomach tissues Vertebrates: endocrinology |
| title | Beyond the metabolic role of ghrelin: A new player in the regulation of reproductive function |
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