The synthesis, magnetic purification and evaluation of 99mTc-labeled microbubbles

Ultrasound (US) contrast agents based on microbubbles (MBs) are being investigated as platforms for drug and gene delivery. A methodology for determining the distribution and fate of modified MBs quantitatively in vivo can be achieved by tagging MBs directly with 99mTc. This creates the opportunity...

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Veröffentlicht in:	Nuclear medicine and biology 2011-11, Vol.38 (8), p.1111-1118
Hauptverfasser:	Lazarova, Neva, Causey, Patrick W., Lemon, Jennifer A., Czorny, Shannon K., Forbes, John R., Zlitni, Aimen, Genady, Afaf, Foster, F. Stuart, Valliant, John F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Contrast Media - chemical synthesis Contrast Media - pharmacokinetics Contrast media. Radiopharmaceuticals Female Intestine, Small - diagnostic imaging Intestine, Small - metabolism Liver - diagnostic imaging Liver - metabolism Medical sciences Mice Mice, Inbred C57BL Microbubbles Organotechnetium Compounds - chemical synthesis Organotechnetium Compounds - pharmacokinetics Pharmacology. Drug treatments Radionuclide Imaging SPECT Spleen - diagnostic imaging Spleen - metabolism Tc-99m Tissue Distribution Tomography, X-Ray Computed Ultrasound Urinary Bladder - diagnostic imaging Urinary Bladder - metabolism
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