Dental sedation for patients with intellectual disability: a prospective study of manual control versus Bispectral Index-guided target-controlled infusion of propofol

Abstract Study Objective To investigate the use of propofol sedation using Bispectral Index (BIS)-guided target-controlled infusion (TCI) in dental patients with intellectual disability. Design Single-center, prospective, randomized clinical trial. Setting Academic outpatient clinic. Subjects 40 ASA...

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Veröffentlicht in:Journal of clinical anesthesia 2011-12, Vol.23 (8), p.636-642
Hauptverfasser: Sakaguchi, Mai, DDS, Higuchi, Hitoshi, DDS, PhD, Maeda, Shigeru, DDS, PhD, Miyawaki, Takuya, DDS, PhD
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container_end_page 642
container_issue 8
container_start_page 636
container_title Journal of clinical anesthesia
container_volume 23
creator Sakaguchi, Mai, DDS
Higuchi, Hitoshi, DDS, PhD
Maeda, Shigeru, DDS, PhD
Miyawaki, Takuya, DDS, PhD
description Abstract Study Objective To investigate the use of propofol sedation using Bispectral Index (BIS)-guided target-controlled infusion (TCI) in dental patients with intellectual disability. Design Single-center, prospective, randomized clinical trial. Setting Academic outpatient clinic. Subjects 40 ASA physical status 1 and 2 patients with intellectual disability. Interventions Patients were randomized to two groups. The manual control (MC) group (n = 20) had sedation by manually controlled infusion of propofol without a BIS index monitor. The BIS-TCI group (n = 20) had sedation by BIS-guided TCI of propofol. Measurements The required dose of propofol, recovery time for the eyelash reflex, and spontaneous eye opening times were recorded. Main Results BIS-TCI significantly reduced the dose of propofol and shortened the recovery times for eyelash reflex and spontaneous eye opening. Conclusion Propofol sedation using BIS-guided TCI is a useful and safe method in the management of patients with intellectual disability.
doi_str_mv 10.1016/j.jclinane.2011.04.008
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Design Single-center, prospective, randomized clinical trial. Setting Academic outpatient clinic. Subjects 40 ASA physical status 1 and 2 patients with intellectual disability. Interventions Patients were randomized to two groups. The manual control (MC) group (n = 20) had sedation by manually controlled infusion of propofol without a BIS index monitor. The BIS-TCI group (n = 20) had sedation by BIS-guided TCI of propofol. Measurements The required dose of propofol, recovery time for the eyelash reflex, and spontaneous eye opening times were recorded. Main Results BIS-TCI significantly reduced the dose of propofol and shortened the recovery times for eyelash reflex and spontaneous eye opening. Conclusion Propofol sedation using BIS-guided TCI is a useful and safe method in the management of patients with intellectual disability.</description><identifier>ISSN: 0952-8180</identifier><identifier>EISSN: 1873-4529</identifier><identifier>DOI: 10.1016/j.jclinane.2011.04.008</identifier><identifier>PMID: 22137516</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Airway management ; Ambulatory Care ; Anesthesia ; Anesthesia &amp; Perioperative Care ; Anesthesia Recovery Period ; Anesthesia, Dental - methods ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anesthetics, Intravenous - administration &amp; dosage ; Anesthetics, Intravenous - pharmacology ; Behavior ; Biological and medical sciences ; Bispectral index ; Consciousness Monitors ; Dental treatments ; Disability ; Dose-Response Relationship, Drug ; Female ; Hospitals ; Humans ; Infusions, Intravenous ; Intellectual Disability ; Intravenous sedation ; Male ; Medical sciences ; Mental retardation ; Pain Medicine ; Propofol - administration &amp; dosage ; Propofol - pharmacology ; Prospective Studies ; Single-Blind Method ; Target-controlled infusion ; Time Factors ; Verbal communication ; Young Adult</subject><ispartof>Journal of clinical anesthesia, 2011-12, Vol.23 (8), p.636-642</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. 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Design Single-center, prospective, randomized clinical trial. Setting Academic outpatient clinic. Subjects 40 ASA physical status 1 and 2 patients with intellectual disability. Interventions Patients were randomized to two groups. The manual control (MC) group (n = 20) had sedation by manually controlled infusion of propofol without a BIS index monitor. The BIS-TCI group (n = 20) had sedation by BIS-guided TCI of propofol. Measurements The required dose of propofol, recovery time for the eyelash reflex, and spontaneous eye opening times were recorded. Main Results BIS-TCI significantly reduced the dose of propofol and shortened the recovery times for eyelash reflex and spontaneous eye opening. 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Design Single-center, prospective, randomized clinical trial. Setting Academic outpatient clinic. Subjects 40 ASA physical status 1 and 2 patients with intellectual disability. Interventions Patients were randomized to two groups. The manual control (MC) group (n = 20) had sedation by manually controlled infusion of propofol without a BIS index monitor. The BIS-TCI group (n = 20) had sedation by BIS-guided TCI of propofol. Measurements The required dose of propofol, recovery time for the eyelash reflex, and spontaneous eye opening times were recorded. Main Results BIS-TCI significantly reduced the dose of propofol and shortened the recovery times for eyelash reflex and spontaneous eye opening. Conclusion Propofol sedation using BIS-guided TCI is a useful and safe method in the management of patients with intellectual disability.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22137516</pmid><doi>10.1016/j.jclinane.2011.04.008</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
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subjects Adult
Airway management
Ambulatory Care
Anesthesia
Anesthesia & Perioperative Care
Anesthesia Recovery Period
Anesthesia, Dental - methods
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthetics, Intravenous - administration & dosage
Anesthetics, Intravenous - pharmacology
Behavior
Biological and medical sciences
Bispectral index
Consciousness Monitors
Dental treatments
Disability
Dose-Response Relationship, Drug
Female
Hospitals
Humans
Infusions, Intravenous
Intellectual Disability
Intravenous sedation
Male
Medical sciences
Mental retardation
Pain Medicine
Propofol - administration & dosage
Propofol - pharmacology
Prospective Studies
Single-Blind Method
Target-controlled infusion
Time Factors
Verbal communication
Young Adult
title Dental sedation for patients with intellectual disability: a prospective study of manual control versus Bispectral Index-guided target-controlled infusion of propofol
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