Diffusion-weighted MRI determined cerebral embolic infarction following transcatheter aortic valve implantation: assessment of predictive risk factors and the relationship to subsequent health status
Background‘Silent’ cerebral infarction and stroke are complications of transcatheter aortic valve implantation (TAVI).ObjectiveTo assess the occurrence of cerebral infarction, identify predictive risk factors and examine the impact on patient health-related quality of life (HRQoL).MethodsCerebral di...
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| Veröffentlicht in: | Heart (British Cardiac Society) 2012-01, Vol.98 (1), p.18-23 |
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| creator | Fairbairn, Timothy A Mather, Adam N Bijsterveld, Petra Worthy, Gillian Currie, Stuart Goddard, Anthony J P Blackman, Daniel J Plein, Sven Greenwood, John P |
| description | Background‘Silent’ cerebral infarction and stroke are complications of transcatheter aortic valve implantation (TAVI).ObjectiveTo assess the occurrence of cerebral infarction, identify predictive risk factors and examine the impact on patient health-related quality of life (HRQoL).MethodsCerebral diffusion weighted MRI of 31 patients with aortic stenosis undergoing CoreValve TAVI was carried out. HRQoL was assessed at baseline and at 30 days by SF-12v2 and EQ5D questionnaires.ResultsNew cerebral infarcts occurred in 24/31 patients (77%) and stroke in 2 (6%). Stroke was associated with a greater number and volume of cerebral infarcts. Age (r=0.37, p=0.042), severity of atheroma (arch and descending aorta; r=0.91, p |
| doi_str_mv | 10.1136/heartjnl-2011-300065 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_908741832</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>908741832</sourcerecordid><originalsourceid>FETCH-LOGICAL-b554t-592523c35177544a0bb1bc83191dd76f6b31b729740b7a37e1ec297abc4451ad3</originalsourceid><addsrcrecordid>eNqNkt1u1DAQhSMEoqXwBghZQoir0Di244S7avmrtID4FXeW7Uy63jrx4nFaeEJeC4dti8QVV_bY3zma8XFRPKTVM0pZc7wBHdN28mVdUVqyqqoacas4pLxpl6Nvt_OeCVE2FZMHxT3EbUZ41zZ3i4OaSiZFSw-LXy_cMMzowlRegjvbJOjJ24-npIcEcXRTLi1EMFF7AqMJ3lnipkFHm7KGDMH7cOmmM5KintDqtFmERIeYMnmh_QUQN-68npJeFM-JRgTEEaZEwkB2EXqXvTIWHZ6TQdsUIhI99SR7kQj-jw43bkdSIDgbhO_zos4P4NOGYDae8X5xZ9Ae4cHVelR8efXy8-pNuX7_-nR1si6NEDyVoqtFzSwTVErBua6Moca2jHa072UzNIZRI-tO8spIzSRQsLnSxnIuqO7ZUfF077uLIbeBSY0OLfg8IIQZVVe1ktOW1Zl8_A-5DXOccnOKyraStK27NlN8T9kYECMMahfdqONPRSu15Kyuc1ZLzmqfc5Y9ujKfzQj9jeg62Aw8uQJ0TsUPOR3r8C8n6i7_Bpa5cs85TPDj5l7Hc9UsVurd15X69IE3db3mapnqeM-bcft_rf4Gkm7WRg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1780718298</pqid></control><display><type>article</type><title>Diffusion-weighted MRI determined cerebral embolic infarction following transcatheter aortic valve implantation: assessment of predictive risk factors and the relationship to subsequent health status</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><source>PubMed Central</source><creator>Fairbairn, Timothy A ; Mather, Adam N ; Bijsterveld, Petra ; Worthy, Gillian ; Currie, Stuart ; Goddard, Anthony J P ; Blackman, Daniel J ; Plein, Sven ; Greenwood, John P</creator><creatorcontrib>Fairbairn, Timothy A ; Mather, Adam N ; Bijsterveld, Petra ; Worthy, Gillian ; Currie, Stuart ; Goddard, Anthony J P ; Blackman, Daniel J ; Plein, Sven ; Greenwood, John P</creatorcontrib><description>Background‘Silent’ cerebral infarction and stroke are complications of transcatheter aortic valve implantation (TAVI).ObjectiveTo assess the occurrence of cerebral infarction, identify predictive risk factors and examine the impact on patient health-related quality of life (HRQoL).MethodsCerebral diffusion weighted MRI of 31 patients with aortic stenosis undergoing CoreValve TAVI was carried out. HRQoL was assessed at baseline and at 30 days by SF-12v2 and EQ5D questionnaires.ResultsNew cerebral infarcts occurred in 24/31 patients (77%) and stroke in 2 (6%). Stroke was associated with a greater number and volume of cerebral infarcts. Age (r=0.37, p=0.042), severity of atheroma (arch and descending aorta; r=0.91, p<0.001, r=0.69, p=0.001, respectively) and catheterisation time (r=0.45, p=0.02) were predictors of the number of new cerebral infarcts. HRQoL improved overall: SF-12v2 physical component summary increased significantly (32.4±6.2 vs 36.5±7.2; p=0.03) with no significant change in mental component summary (43.5±11.7 vs 43.1±14.3; p=0.85). The EQ5D score and Visual Analogue Scale showed no significant change (0.56±0.26 vs 0.59±0.31; p=0.70, and 54.2±19 vs 58.2±24; p=0.43).ConclusionMultiple small cerebral infarcts occurred in 77% of patients with TAVI. The majority of infarcts were ‘silent’ with clinical stroke being associated with a both higher infarct number and volume. Increased age and the severity of aortic arch atheroma were independent risk factors for the development of new cerebral infarcts. Overall HRQoL improved and there was no association between the number of new cerebral infarcts and altered health status.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/heartjnl-2011-300065</identifier><identifier>PMID: 21737581</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><subject>acute myocardial infarction ; Aged ; Aged, 80 and over ; Aortic stenosis ; Aortic Valve Stenosis - therapy ; Biological and medical sciences ; Calcification ; Cardiac Catheterization - adverse effects ; Cardiology. Vascular system ; Cerebral Infarction - diagnosis ; Cerebral Infarction - etiology ; Clinical outcomes ; Cognitive ability ; Comorbidity ; coronary intervention ; coronary stenting ; Diffusion ; Diffusion Magnetic Resonance Imaging - methods ; echocardiography ; Female ; Health Status ; Heart surgery ; Heart Valve Prolapse ; Heart Valve Prosthesis Implantation - adverse effects ; Humans ; interventional cardiology ; Intracranial Embolism - diagnosis ; Intracranial Embolism - etiology ; intravascular ultrasound ; Magnetic Resonance Angiography - methods ; Male ; Medical sciences ; Medical treatment ; Mental health ; Mortality ; MRI ; Neurologic Examination ; Neurology ; Plaque, Atherosclerotic - diagnosis ; Quality of life ; Questionnaires ; Risk Factors ; Software ; Statistical analysis ; Stroke ; Stroke - diagnosis ; Stroke - etiology ; Studies ; TAVI ; Vascular Calcification - therapy ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Heart (British Cardiac Society), 2012-01, Vol.98 (1), p.18-23</ispartof><rights>2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright: 2011 (c) 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b554t-592523c35177544a0bb1bc83191dd76f6b31b729740b7a37e1ec297abc4451ad3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://heart.bmj.com/content/98/1/18.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://heart.bmj.com/content/98/1/18.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3182,23551,27903,27904,77346,77377</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25290043$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21737581$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fairbairn, Timothy A</creatorcontrib><creatorcontrib>Mather, Adam N</creatorcontrib><creatorcontrib>Bijsterveld, Petra</creatorcontrib><creatorcontrib>Worthy, Gillian</creatorcontrib><creatorcontrib>Currie, Stuart</creatorcontrib><creatorcontrib>Goddard, Anthony J P</creatorcontrib><creatorcontrib>Blackman, Daniel J</creatorcontrib><creatorcontrib>Plein, Sven</creatorcontrib><creatorcontrib>Greenwood, John P</creatorcontrib><title>Diffusion-weighted MRI determined cerebral embolic infarction following transcatheter aortic valve implantation: assessment of predictive risk factors and the relationship to subsequent health status</title><title>Heart (British Cardiac Society)</title><addtitle>Heart</addtitle><description>Background‘Silent’ cerebral infarction and stroke are complications of transcatheter aortic valve implantation (TAVI).ObjectiveTo assess the occurrence of cerebral infarction, identify predictive risk factors and examine the impact on patient health-related quality of life (HRQoL).MethodsCerebral diffusion weighted MRI of 31 patients with aortic stenosis undergoing CoreValve TAVI was carried out. HRQoL was assessed at baseline and at 30 days by SF-12v2 and EQ5D questionnaires.ResultsNew cerebral infarcts occurred in 24/31 patients (77%) and stroke in 2 (6%). Stroke was associated with a greater number and volume of cerebral infarcts. Age (r=0.37, p=0.042), severity of atheroma (arch and descending aorta; r=0.91, p<0.001, r=0.69, p=0.001, respectively) and catheterisation time (r=0.45, p=0.02) were predictors of the number of new cerebral infarcts. HRQoL improved overall: SF-12v2 physical component summary increased significantly (32.4±6.2 vs 36.5±7.2; p=0.03) with no significant change in mental component summary (43.5±11.7 vs 43.1±14.3; p=0.85). The EQ5D score and Visual Analogue Scale showed no significant change (0.56±0.26 vs 0.59±0.31; p=0.70, and 54.2±19 vs 58.2±24; p=0.43).ConclusionMultiple small cerebral infarcts occurred in 77% of patients with TAVI. The majority of infarcts were ‘silent’ with clinical stroke being associated with a both higher infarct number and volume. Increased age and the severity of aortic arch atheroma were independent risk factors for the development of new cerebral infarcts. Overall HRQoL improved and there was no association between the number of new cerebral infarcts and altered health status.</description><subject>acute myocardial infarction</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aortic stenosis</subject><subject>Aortic Valve Stenosis - therapy</subject><subject>Biological and medical sciences</subject><subject>Calcification</subject><subject>Cardiac Catheterization - adverse effects</subject><subject>Cardiology. Vascular system</subject><subject>Cerebral Infarction - diagnosis</subject><subject>Cerebral Infarction - etiology</subject><subject>Clinical outcomes</subject><subject>Cognitive ability</subject><subject>Comorbidity</subject><subject>coronary intervention</subject><subject>coronary stenting</subject><subject>Diffusion</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>echocardiography</subject><subject>Female</subject><subject>Health Status</subject><subject>Heart surgery</subject><subject>Heart Valve Prolapse</subject><subject>Heart Valve Prosthesis Implantation - adverse effects</subject><subject>Humans</subject><subject>interventional cardiology</subject><subject>Intracranial Embolism - diagnosis</subject><subject>Intracranial Embolism - etiology</subject><subject>intravascular ultrasound</subject><subject>Magnetic Resonance Angiography - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Mental health</subject><subject>Mortality</subject><subject>MRI</subject><subject>Neurologic Examination</subject><subject>Neurology</subject><subject>Plaque, Atherosclerotic - diagnosis</subject><subject>Quality of life</subject><subject>Questionnaires</subject><subject>Risk Factors</subject><subject>Software</subject><subject>Statistical analysis</subject><subject>Stroke</subject><subject>Stroke - diagnosis</subject><subject>Stroke - etiology</subject><subject>Studies</subject><subject>TAVI</subject><subject>Vascular Calcification - therapy</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>1355-6037</issn><issn>1468-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkt1u1DAQhSMEoqXwBghZQoir0Di244S7avmrtID4FXeW7Uy63jrx4nFaeEJeC4dti8QVV_bY3zma8XFRPKTVM0pZc7wBHdN28mVdUVqyqqoacas4pLxpl6Nvt_OeCVE2FZMHxT3EbUZ41zZ3i4OaSiZFSw-LXy_cMMzowlRegjvbJOjJ24-npIcEcXRTLi1EMFF7AqMJ3lnipkFHm7KGDMH7cOmmM5KintDqtFmERIeYMnmh_QUQN-68npJeFM-JRgTEEaZEwkB2EXqXvTIWHZ6TQdsUIhI99SR7kQj-jw43bkdSIDgbhO_zos4P4NOGYDae8X5xZ9Ae4cHVelR8efXy8-pNuX7_-nR1si6NEDyVoqtFzSwTVErBua6Moca2jHa072UzNIZRI-tO8spIzSRQsLnSxnIuqO7ZUfF077uLIbeBSY0OLfg8IIQZVVe1ktOW1Zl8_A-5DXOccnOKyraStK27NlN8T9kYECMMahfdqONPRSu15Kyuc1ZLzmqfc5Y9ujKfzQj9jeg62Aw8uQJ0TsUPOR3r8C8n6i7_Bpa5cs85TPDj5l7Hc9UsVurd15X69IE3db3mapnqeM-bcft_rf4Gkm7WRg</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Fairbairn, Timothy A</creator><creator>Mather, Adam N</creator><creator>Bijsterveld, Petra</creator><creator>Worthy, Gillian</creator><creator>Currie, Stuart</creator><creator>Goddard, Anthony J P</creator><creator>Blackman, Daniel J</creator><creator>Plein, Sven</creator><creator>Greenwood, John P</creator><general>BMJ Publishing Group Ltd and British Cardiovascular Society</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20120101</creationdate><title>Diffusion-weighted MRI determined cerebral embolic infarction following transcatheter aortic valve implantation: assessment of predictive risk factors and the relationship to subsequent health status</title><author>Fairbairn, Timothy A ; Mather, Adam N ; Bijsterveld, Petra ; Worthy, Gillian ; Currie, Stuart ; Goddard, Anthony J P ; Blackman, Daniel J ; Plein, Sven ; Greenwood, John P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b554t-592523c35177544a0bb1bc83191dd76f6b31b729740b7a37e1ec297abc4451ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>acute myocardial infarction</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aortic stenosis</topic><topic>Aortic Valve Stenosis - therapy</topic><topic>Biological and medical sciences</topic><topic>Calcification</topic><topic>Cardiac Catheterization - adverse effects</topic><topic>Cardiology. Vascular system</topic><topic>Cerebral Infarction - diagnosis</topic><topic>Cerebral Infarction - etiology</topic><topic>Clinical outcomes</topic><topic>Cognitive ability</topic><topic>Comorbidity</topic><topic>coronary intervention</topic><topic>coronary stenting</topic><topic>Diffusion</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>echocardiography</topic><topic>Female</topic><topic>Health Status</topic><topic>Heart surgery</topic><topic>Heart Valve Prolapse</topic><topic>Heart Valve Prosthesis Implantation - adverse effects</topic><topic>Humans</topic><topic>interventional cardiology</topic><topic>Intracranial Embolism - diagnosis</topic><topic>Intracranial Embolism - etiology</topic><topic>intravascular ultrasound</topic><topic>Magnetic Resonance Angiography - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medical treatment</topic><topic>Mental health</topic><topic>Mortality</topic><topic>MRI</topic><topic>Neurologic Examination</topic><topic>Neurology</topic><topic>Plaque, Atherosclerotic - diagnosis</topic><topic>Quality of life</topic><topic>Questionnaires</topic><topic>Risk Factors</topic><topic>Software</topic><topic>Statistical analysis</topic><topic>Stroke</topic><topic>Stroke - diagnosis</topic><topic>Stroke - etiology</topic><topic>Studies</topic><topic>TAVI</topic><topic>Vascular Calcification - therapy</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fairbairn, Timothy A</creatorcontrib><creatorcontrib>Mather, Adam N</creatorcontrib><creatorcontrib>Bijsterveld, Petra</creatorcontrib><creatorcontrib>Worthy, Gillian</creatorcontrib><creatorcontrib>Currie, Stuart</creatorcontrib><creatorcontrib>Goddard, Anthony J P</creatorcontrib><creatorcontrib>Blackman, Daniel J</creatorcontrib><creatorcontrib>Plein, Sven</creatorcontrib><creatorcontrib>Greenwood, John P</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Heart (British Cardiac Society)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fairbairn, Timothy A</au><au>Mather, Adam N</au><au>Bijsterveld, Petra</au><au>Worthy, Gillian</au><au>Currie, Stuart</au><au>Goddard, Anthony J P</au><au>Blackman, Daniel J</au><au>Plein, Sven</au><au>Greenwood, John P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diffusion-weighted MRI determined cerebral embolic infarction following transcatheter aortic valve implantation: assessment of predictive risk factors and the relationship to subsequent health status</atitle><jtitle>Heart (British Cardiac Society)</jtitle><addtitle>Heart</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>98</volume><issue>1</issue><spage>18</spage><epage>23</epage><pages>18-23</pages><issn>1355-6037</issn><eissn>1468-201X</eissn><abstract>Background‘Silent’ cerebral infarction and stroke are complications of transcatheter aortic valve implantation (TAVI).ObjectiveTo assess the occurrence of cerebral infarction, identify predictive risk factors and examine the impact on patient health-related quality of life (HRQoL).MethodsCerebral diffusion weighted MRI of 31 patients with aortic stenosis undergoing CoreValve TAVI was carried out. HRQoL was assessed at baseline and at 30 days by SF-12v2 and EQ5D questionnaires.ResultsNew cerebral infarcts occurred in 24/31 patients (77%) and stroke in 2 (6%). Stroke was associated with a greater number and volume of cerebral infarcts. Age (r=0.37, p=0.042), severity of atheroma (arch and descending aorta; r=0.91, p<0.001, r=0.69, p=0.001, respectively) and catheterisation time (r=0.45, p=0.02) were predictors of the number of new cerebral infarcts. HRQoL improved overall: SF-12v2 physical component summary increased significantly (32.4±6.2 vs 36.5±7.2; p=0.03) with no significant change in mental component summary (43.5±11.7 vs 43.1±14.3; p=0.85). The EQ5D score and Visual Analogue Scale showed no significant change (0.56±0.26 vs 0.59±0.31; p=0.70, and 54.2±19 vs 58.2±24; p=0.43).ConclusionMultiple small cerebral infarcts occurred in 77% of patients with TAVI. The majority of infarcts were ‘silent’ with clinical stroke being associated with a both higher infarct number and volume. Increased age and the severity of aortic arch atheroma were independent risk factors for the development of new cerebral infarcts. Overall HRQoL improved and there was no association between the number of new cerebral infarcts and altered health status.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><pmid>21737581</pmid><doi>10.1136/heartjnl-2011-300065</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | acute myocardial infarction Aged Aged, 80 and over Aortic stenosis Aortic Valve Stenosis - therapy Biological and medical sciences Calcification Cardiac Catheterization - adverse effects Cardiology. Vascular system Cerebral Infarction - diagnosis Cerebral Infarction - etiology Clinical outcomes Cognitive ability Comorbidity coronary intervention coronary stenting Diffusion Diffusion Magnetic Resonance Imaging - methods echocardiography Female Health Status Heart surgery Heart Valve Prolapse Heart Valve Prosthesis Implantation - adverse effects Humans interventional cardiology Intracranial Embolism - diagnosis Intracranial Embolism - etiology intravascular ultrasound Magnetic Resonance Angiography - methods Male Medical sciences Medical treatment Mental health Mortality MRI Neurologic Examination Neurology Plaque, Atherosclerotic - diagnosis Quality of life Questionnaires Risk Factors Software Statistical analysis Stroke Stroke - diagnosis Stroke - etiology Studies TAVI Vascular Calcification - therapy Vascular diseases and vascular malformations of the nervous system |
| title | Diffusion-weighted MRI determined cerebral embolic infarction following transcatheter aortic valve implantation: assessment of predictive risk factors and the relationship to subsequent health status |
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