Role of Bundle Helices in a Regulatory Crosstalk in the Trimeric Betaine Transporter BetP

The Na +-coupled betaine symporter BetP regulates transport activity in response to hyperosmotic stress only in its trimeric state, suggesting a regulatory crosstalk between individual protomers. BetP shares the overall fold of two inverted structurally related five-transmembrane (TM) helix repeats...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of molecular biology 2011-12, Vol.414 (3), p.327-336
Hauptverfasser:	Gärtner, Rebecca M., Perez, Camilo, Koshy, Caroline, Ziegler, Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	alternating access Bacterial Proteins - chemistry Bacterial Proteins - metabolism betaine Betaine - chemistry betaine transport Biological Transport Carrier Proteins - chemistry Carrier Proteins - metabolism Corynebacterium glutamicum - metabolism crosslinking Crystallography, X-Ray - methods Dimerization Dose-Response Relationship, Drug Electrophoresis, Polyacrylamide Gel - methods Escherichia coli - metabolism inverted repeats Kinetics Models, Molecular Mutagenesis, Site-Directed Na + coupling Osmolar Concentration Protein Conformation Protein Structure, Secondary protein subunits site-directed mutagenesis Symporters transport activity regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!