Low circulating Dickkopf-1 and its link with severity of spinal involvement in diffuse idiopathic skeletal hyperostosis
Objective Dickkopf-1 (DKK-1) is an inhibitor of osteoblastogenesis, and its lower levels are linked to new bone formation. The aim of this study was therefore to explore serum levels of DKK-1 and to evaluate DKK-1's association with the severity of spinal involvement in diffuse idiopathic skele...
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| Veröffentlicht in: | Annals of the rheumatic diseases 2012-01, Vol.71 (1), p.71-74 |
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| creator | Senolt, L Hulejova, H Krystufkova, O Forejtova, S Andres Cerezo, L Gatterova, J Pavelka, K Vencovsky, J |
| description | Objective Dickkopf-1 (DKK-1) is an inhibitor of osteoblastogenesis, and its lower levels are linked to new bone formation. The aim of this study was therefore to explore serum levels of DKK-1 and to evaluate DKK-1's association with the severity of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Methods Serum levels of total and functional DKK-1 and C-reactive protein (CRP) were measured in 37 patients with DISH and 22 healthy age and sex-matched controls. Plain radiographs of the cervical and thoracic spine were performed, and the diagnosis of DISH was defined using the Resnick criteria. Patients were divided into three groups based on spinal involvement. Bone mineral density (BMD) and bone turnover markers were evaluated in patients with DISH. Results The levels of total serum DKK-1 were significantly lower in patients with DISH than in healthy controls (p |
| doi_str_mv | 10.1136/annrheumdis-2011-200357 |
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The aim of this study was therefore to explore serum levels of DKK-1 and to evaluate DKK-1's association with the severity of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Methods Serum levels of total and functional DKK-1 and C-reactive protein (CRP) were measured in 37 patients with DISH and 22 healthy age and sex-matched controls. Plain radiographs of the cervical and thoracic spine were performed, and the diagnosis of DISH was defined using the Resnick criteria. Patients were divided into three groups based on spinal involvement. Bone mineral density (BMD) and bone turnover markers were evaluated in patients with DISH. Results The levels of total serum DKK-1 were significantly lower in patients with DISH than in healthy controls (p<0.0001). Importantly, low serum levels of DKK-1 were associated with more severe spinal involvement in DISH, independent of age, sex, disease duration, CRP, bone turnover markers or BMD. However, these findings were less significant for functional DKK-1. Conclusion These observations indicate that DKK-1 may play a significant role in bone formation during DISH.</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/annrheumdis-2011-200357</identifier><identifier>PMID: 21900287</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><subject>Age ; Aged ; Arthritis ; Biological and medical sciences ; Biomarkers - blood ; Bone density ; Bone Density - physiology ; Bone mineral density ; Bone Remodeling - physiology ; Bone turnover ; C-reactive protein ; C-Reactive Protein - metabolism ; Case-Control Studies ; Diabetes ; Diseases of the osteoarticular system ; Diseases of the spine ; Dkk1 protein ; Female ; Humans ; Hyperostosis, Diffuse Idiopathic Skeletal - blood ; Hyperostosis, Diffuse Idiopathic Skeletal - diagnostic imaging ; Hyperostosis, Diffuse Idiopathic Skeletal - physiopathology ; Intercellular Signaling Peptides and Proteins - blood ; Male ; Medical sciences ; Metabolism ; Middle Aged ; Osteoblastogenesis ; Osteogenesis ; Osteoporosis ; Patients ; Proteins ; Radiography ; Serum levels ; Severity of Illness Index ; Sex ; Spine ; Statistical analysis ; Thoracic Vertebrae - diagnostic imaging ; Vertebrae</subject><ispartof>Annals of the rheumatic diseases, 2012-01, Vol.71 (1), p.71-74</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>2015 INIST-CNRS</rights><rights>Copyright: 2011 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b484t-76b547fb74018dfde8eef1015c66de4926c25b93a4d12492507179c9cb24f9ef3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://ard.bmj.com/content/71/1/71.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://ard.bmj.com/content/71/1/71.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,3196,4024,23571,27923,27924,27925,77600,77631</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25292883$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21900287$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Senolt, L</creatorcontrib><creatorcontrib>Hulejova, H</creatorcontrib><creatorcontrib>Krystufkova, O</creatorcontrib><creatorcontrib>Forejtova, S</creatorcontrib><creatorcontrib>Andres Cerezo, L</creatorcontrib><creatorcontrib>Gatterova, J</creatorcontrib><creatorcontrib>Pavelka, K</creatorcontrib><creatorcontrib>Vencovsky, J</creatorcontrib><title>Low circulating Dickkopf-1 and its link with severity of spinal involvement in diffuse idiopathic skeletal hyperostosis</title><title>Annals of the rheumatic diseases</title><addtitle>Ann Rheum Dis</addtitle><description>Objective Dickkopf-1 (DKK-1) is an inhibitor of osteoblastogenesis, and its lower levels are linked to new bone formation. The aim of this study was therefore to explore serum levels of DKK-1 and to evaluate DKK-1's association with the severity of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Methods Serum levels of total and functional DKK-1 and C-reactive protein (CRP) were measured in 37 patients with DISH and 22 healthy age and sex-matched controls. Plain radiographs of the cervical and thoracic spine were performed, and the diagnosis of DISH was defined using the Resnick criteria. Patients were divided into three groups based on spinal involvement. Bone mineral density (BMD) and bone turnover markers were evaluated in patients with DISH. Results The levels of total serum DKK-1 were significantly lower in patients with DISH than in healthy controls (p<0.0001). Importantly, low serum levels of DKK-1 were associated with more severe spinal involvement in DISH, independent of age, sex, disease duration, CRP, bone turnover markers or BMD. However, these findings were less significant for functional DKK-1. Conclusion These observations indicate that DKK-1 may play a significant role in bone formation during DISH.</description><subject>Age</subject><subject>Aged</subject><subject>Arthritis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Bone density</subject><subject>Bone Density - physiology</subject><subject>Bone mineral density</subject><subject>Bone Remodeling - physiology</subject><subject>Bone turnover</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Case-Control Studies</subject><subject>Diabetes</subject><subject>Diseases of the osteoarticular system</subject><subject>Diseases of the spine</subject><subject>Dkk1 protein</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperostosis, Diffuse Idiopathic Skeletal - blood</subject><subject>Hyperostosis, Diffuse Idiopathic Skeletal - diagnostic imaging</subject><subject>Hyperostosis, Diffuse Idiopathic Skeletal - physiopathology</subject><subject>Intercellular Signaling Peptides and Proteins - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Osteoblastogenesis</subject><subject>Osteogenesis</subject><subject>Osteoporosis</subject><subject>Patients</subject><subject>Proteins</subject><subject>Radiography</subject><subject>Serum levels</subject><subject>Severity of Illness Index</subject><subject>Sex</subject><subject>Spine</subject><subject>Statistical analysis</subject><subject>Thoracic Vertebrae - diagnostic imaging</subject><subject>Vertebrae</subject><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqN0cuu0zAQBuAIgTjlwCuAJYRgE7CdxJcllLsqOAtgaznOmLq5YjstfXtcpVSIBWLjeJJvRo7_LHtE8HNCCvZCD4Pfwtw3LuQUE5IWXFT8VrYiJROpYvh2tsLpZV5Kxq-yeyHsUokFEXezK0okxlTwVXbYjAdknDdzp6MbvqPXzrTtONmcID00yMWAOje06ODiFgXYg3fxiEaLwuQG3SE37MduDz0MMe1R46ydAyDXuHHScesMCi10EBPdHifwY4hjcOF-dsfqLsCD8_M6-_r2zZf1-3zz-d2H9ctNXpeijDlndVVyW_MSE9HYBgSAJZhUhrEGSkmZoVUtC102hKaywpxwaaSpaWkl2OI6e7rMnfz4Y4YQVe-Cga7TA4xzUBILTCilLMln_5QkXRjmkpITffwX3Y2zT7eRFOcCM45JmRRflEk_HTxYNXnXa39Mo9QpRfVHiuqUolpSTJ0Pz_Pnuofm0vc7tgSenIEORnfW68GkGRdXUUmFKJLLF-dChJ-X79q3ivGCV-rTt7V6JW8-Yo436iZ5uvi63_33aX8ByZPI4w</recordid><startdate>201201</startdate><enddate>201201</enddate><creator>Senolt, L</creator><creator>Hulejova, H</creator><creator>Krystufkova, O</creator><creator>Forejtova, S</creator><creator>Andres Cerezo, L</creator><creator>Gatterova, J</creator><creator>Pavelka, K</creator><creator>Vencovsky, J</creator><general>BMJ Publishing Group Ltd and European League Against Rheumatism</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>201201</creationdate><title>Low circulating Dickkopf-1 and its link with severity of spinal involvement in diffuse idiopathic skeletal hyperostosis</title><author>Senolt, L ; Hulejova, H ; Krystufkova, O ; Forejtova, S ; Andres Cerezo, L ; Gatterova, J ; Pavelka, K ; Vencovsky, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b484t-76b547fb74018dfde8eef1015c66de4926c25b93a4d12492507179c9cb24f9ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age</topic><topic>Aged</topic><topic>Arthritis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Bone density</topic><topic>Bone Density - physiology</topic><topic>Bone mineral density</topic><topic>Bone Remodeling - physiology</topic><topic>Bone turnover</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Case-Control Studies</topic><topic>Diabetes</topic><topic>Diseases of the osteoarticular system</topic><topic>Diseases of the spine</topic><topic>Dkk1 protein</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperostosis, Diffuse Idiopathic Skeletal - blood</topic><topic>Hyperostosis, Diffuse Idiopathic Skeletal - diagnostic imaging</topic><topic>Hyperostosis, Diffuse Idiopathic Skeletal - physiopathology</topic><topic>Intercellular Signaling Peptides and Proteins - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Osteoblastogenesis</topic><topic>Osteogenesis</topic><topic>Osteoporosis</topic><topic>Patients</topic><topic>Proteins</topic><topic>Radiography</topic><topic>Serum levels</topic><topic>Severity of Illness Index</topic><topic>Sex</topic><topic>Spine</topic><topic>Statistical analysis</topic><topic>Thoracic Vertebrae - diagnostic imaging</topic><topic>Vertebrae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Senolt, L</creatorcontrib><creatorcontrib>Hulejova, H</creatorcontrib><creatorcontrib>Krystufkova, O</creatorcontrib><creatorcontrib>Forejtova, S</creatorcontrib><creatorcontrib>Andres Cerezo, L</creatorcontrib><creatorcontrib>Gatterova, J</creatorcontrib><creatorcontrib>Pavelka, K</creatorcontrib><creatorcontrib>Vencovsky, J</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Senolt, L</au><au>Hulejova, H</au><au>Krystufkova, O</au><au>Forejtova, S</au><au>Andres Cerezo, L</au><au>Gatterova, J</au><au>Pavelka, K</au><au>Vencovsky, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low circulating Dickkopf-1 and its link with severity of spinal involvement in diffuse idiopathic skeletal hyperostosis</atitle><jtitle>Annals of the rheumatic diseases</jtitle><addtitle>Ann Rheum Dis</addtitle><date>2012-01</date><risdate>2012</risdate><volume>71</volume><issue>1</issue><spage>71</spage><epage>74</epage><pages>71-74</pages><issn>0003-4967</issn><eissn>1468-2060</eissn><coden>ARDIAO</coden><abstract>Objective Dickkopf-1 (DKK-1) is an inhibitor of osteoblastogenesis, and its lower levels are linked to new bone formation. The aim of this study was therefore to explore serum levels of DKK-1 and to evaluate DKK-1's association with the severity of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Methods Serum levels of total and functional DKK-1 and C-reactive protein (CRP) were measured in 37 patients with DISH and 22 healthy age and sex-matched controls. Plain radiographs of the cervical and thoracic spine were performed, and the diagnosis of DISH was defined using the Resnick criteria. Patients were divided into three groups based on spinal involvement. Bone mineral density (BMD) and bone turnover markers were evaluated in patients with DISH. Results The levels of total serum DKK-1 were significantly lower in patients with DISH than in healthy controls (p<0.0001). Importantly, low serum levels of DKK-1 were associated with more severe spinal involvement in DISH, independent of age, sex, disease duration, CRP, bone turnover markers or BMD. However, these findings were less significant for functional DKK-1. Conclusion These observations indicate that DKK-1 may play a significant role in bone formation during DISH.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and European League Against Rheumatism</pub><pmid>21900287</pmid><doi>10.1136/annrheumdis-2011-200357</doi><tpages>4</tpages></addata></record> |
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| subjects | Age Aged Arthritis Biological and medical sciences Biomarkers - blood Bone density Bone Density - physiology Bone mineral density Bone Remodeling - physiology Bone turnover C-reactive protein C-Reactive Protein - metabolism Case-Control Studies Diabetes Diseases of the osteoarticular system Diseases of the spine Dkk1 protein Female Humans Hyperostosis, Diffuse Idiopathic Skeletal - blood Hyperostosis, Diffuse Idiopathic Skeletal - diagnostic imaging Hyperostosis, Diffuse Idiopathic Skeletal - physiopathology Intercellular Signaling Peptides and Proteins - blood Male Medical sciences Metabolism Middle Aged Osteoblastogenesis Osteogenesis Osteoporosis Patients Proteins Radiography Serum levels Severity of Illness Index Sex Spine Statistical analysis Thoracic Vertebrae - diagnostic imaging Vertebrae |
| title | Low circulating Dickkopf-1 and its link with severity of spinal involvement in diffuse idiopathic skeletal hyperostosis |
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