Indomethacin Ameliorates Trimethyltin-Induced Neuronal Damage in Vivo by Attenuating Oxidative Stress in the Dentate Gyrus of Mice

The organotin trimethyltin (TMT) is well known to cause neuronal degeneration in the hippocampal dentate gyrus of mice. The first purpose of the present study was to examine whether the cyclooxygenase (COX) inhibitor indomethacin could ameliorate neuronal degeneration in the dentate gyrus of mice fo...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2011/12/01, Vol.34(12), pp.1856-1863
Hauptverfasser:	Huong, Nguyen Quynh, Nakamura, Yukary, Kuramoto, Nobuyuki, Yoneyama, Masanori, Nagashima, Reiko, Shiba, Tatsuo, Yamaguchi, Taro, Hasebe, Shigeru, Ogita, Kiyokazu
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Hydroxynonenal Aldehydes - metabolism Animals Calpain Caspase 3 - metabolism Caspase-3 cyclooxygenase Cyclooxygenase 1 - genetics Cyclooxygenase 1 - metabolism Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Cyclooxygenase Inhibitors - pharmacology Cyclooxygenase Inhibitors - therapeutic use Cyclooxygenase-1 Cyclooxygenase-2 Data processing Degeneration Dentate gyrus Dentate Gyrus - drug effects Dentate Gyrus - metabolism DNA Gene expression Granule cells Hippocampus Hippocampus - drug effects Hippocampus - metabolism Indomethacin Indomethacin - pharmacology Indomethacin - therapeutic use Lipid peroxidation Male Mice Microglia - cytology Microglia - drug effects Microglia - metabolism Microglial cells Nerve Degeneration - chemically induced Nerve Degeneration - drug therapy Nerve Degeneration - metabolism neuronal degeneration Neurons Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Organotin Oxidative stress Oxidative Stress - drug effects Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Trimethyltin Trimethyltin Compounds - toxicity
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