WT1 in disease: shifting the epithelial-mesenchymal balance

WT1 is a versatile gene that controls transitions between the mesenchymal and epithelial state of cells in a tissue‐context dependent manner. As such, WT1 is indispensable for normal development of many organs and tissues. Uncontrolled epithelial to mesenchymal transition (EMT) is a hallmark of a di...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The Journal of pathology 2012-01, Vol.226 (2), p.229-240
Hauptverfasser: Miller-Hodges, Eve, Hohenstein, Peter
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 240
container_issue 2
container_start_page 229
container_title The Journal of pathology
container_volume 226
creator Miller-Hodges, Eve
Hohenstein, Peter
description WT1 is a versatile gene that controls transitions between the mesenchymal and epithelial state of cells in a tissue‐context dependent manner. As such, WT1 is indispensable for normal development of many organs and tissues. Uncontrolled epithelial to mesenchymal transition (EMT) is a hallmark of a diverse array of pathologies and disturbance of mesenchymal to epithelial transition (MET) has been associated with a number of developmental abnormalities. It is therefore not surprising that WT1 has been linked to many of these. Here we review the role of WT1 in proper control of the mesenchymal–epithelial balance of cells and discuss how far these roles can explain the role of WT1 in a variety of disease states. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
doi_str_mv 10.1002/path.2977
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_908008908</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>908008908</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4637-cf2b7e89291c55936e026b0f7d1464ff031bf71d1cbc90da9cabf20982df75743</originalsourceid><addsrcrecordid>eNp1kM1OwzAQhC0EoqVw4AVQbohDiu38OIZTVWiLqIBDUSUuluOsiSFJQ5wK-va4SumNy85K-81oNQidEzwkGNPrWrb5kHLGDlCfYB77POHxIeq7G_WDkLAeOrH2A2PMeRQdox4lPHIr7aPb5YJ4pvIyY0FauPFsbnRrqnevzcGD2jgpjCz8EixUKt-UsvBSWchKwSk60rKwcLbTAXqd3C_GM3_-PH0Yj-a-CuOA-UrTlEHCKScqingQA6ZxijXLSBiHWuOApJqRjKhUcZxJrmSqKeYJzTSLWBgM0GWXWzerrzXYVpTGKijcE7BaW8FxgnHipiOvOlI1K2sb0KJuTCmbjSBYbKsS26rEtirHXuxS12kJ2Z7868YB1x3wbQrY_J8kXkaL2S7S7xzGtvCzd8jmU8QsYJFYPk3Fcjrh47fHibgLfgGXf4Hl</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>908008908</pqid></control><display><type>article</type><title>WT1 in disease: shifting the epithelial-mesenchymal balance</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Miller-Hodges, Eve ; Hohenstein, Peter</creator><creatorcontrib>Miller-Hodges, Eve ; Hohenstein, Peter</creatorcontrib><description>WT1 is a versatile gene that controls transitions between the mesenchymal and epithelial state of cells in a tissue‐context dependent manner. As such, WT1 is indispensable for normal development of many organs and tissues. Uncontrolled epithelial to mesenchymal transition (EMT) is a hallmark of a diverse array of pathologies and disturbance of mesenchymal to epithelial transition (MET) has been associated with a number of developmental abnormalities. It is therefore not surprising that WT1 has been linked to many of these. Here we review the role of WT1 in proper control of the mesenchymal–epithelial balance of cells and discuss how far these roles can explain the role of WT1 in a variety of disease states. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.</description><identifier>ISSN: 0022-3417</identifier><identifier>EISSN: 1096-9896</identifier><identifier>DOI: 10.1002/path.2977</identifier><identifier>PMID: 21959952</identifier><language>eng</language><publisher>Chichester, UK: John Wiley &amp; Sons, Ltd</publisher><subject>Animals ; cancer ; Cardiovascular Diseases - genetics ; Disease Models, Animal ; Embryonic Development - genetics ; EMT ; Epithelial-Mesenchymal Transition - genetics ; Epithelium - pathology ; Genes, Wilms Tumor - physiology ; Gonadal Dysgenesis, 46,XY - genetics ; Humans ; kidney ; Kidney - embryology ; Kidney Neoplasms - genetics ; Kidney Neoplasms - pathology ; Mesoderm - pathology ; MET ; Mice ; Mutation - genetics ; Oncogenes - physiology ; podocyte ; Regeneration - genetics ; Wilms Tumor - genetics ; Wilms Tumor - pathology ; WT1</subject><ispartof>The Journal of pathology, 2012-01, Vol.226 (2), p.229-240</ispartof><rights>Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4637-cf2b7e89291c55936e026b0f7d1464ff031bf71d1cbc90da9cabf20982df75743</citedby><cites>FETCH-LOGICAL-c4637-cf2b7e89291c55936e026b0f7d1464ff031bf71d1cbc90da9cabf20982df75743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpath.2977$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpath.2977$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21959952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miller-Hodges, Eve</creatorcontrib><creatorcontrib>Hohenstein, Peter</creatorcontrib><title>WT1 in disease: shifting the epithelial-mesenchymal balance</title><title>The Journal of pathology</title><addtitle>J. Pathol</addtitle><description>WT1 is a versatile gene that controls transitions between the mesenchymal and epithelial state of cells in a tissue‐context dependent manner. As such, WT1 is indispensable for normal development of many organs and tissues. Uncontrolled epithelial to mesenchymal transition (EMT) is a hallmark of a diverse array of pathologies and disturbance of mesenchymal to epithelial transition (MET) has been associated with a number of developmental abnormalities. It is therefore not surprising that WT1 has been linked to many of these. Here we review the role of WT1 in proper control of the mesenchymal–epithelial balance of cells and discuss how far these roles can explain the role of WT1 in a variety of disease states. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.</description><subject>Animals</subject><subject>cancer</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Disease Models, Animal</subject><subject>Embryonic Development - genetics</subject><subject>EMT</subject><subject>Epithelial-Mesenchymal Transition - genetics</subject><subject>Epithelium - pathology</subject><subject>Genes, Wilms Tumor - physiology</subject><subject>Gonadal Dysgenesis, 46,XY - genetics</subject><subject>Humans</subject><subject>kidney</subject><subject>Kidney - embryology</subject><subject>Kidney Neoplasms - genetics</subject><subject>Kidney Neoplasms - pathology</subject><subject>Mesoderm - pathology</subject><subject>MET</subject><subject>Mice</subject><subject>Mutation - genetics</subject><subject>Oncogenes - physiology</subject><subject>podocyte</subject><subject>Regeneration - genetics</subject><subject>Wilms Tumor - genetics</subject><subject>Wilms Tumor - pathology</subject><subject>WT1</subject><issn>0022-3417</issn><issn>1096-9896</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1OwzAQhC0EoqVw4AVQbohDiu38OIZTVWiLqIBDUSUuluOsiSFJQ5wK-va4SumNy85K-81oNQidEzwkGNPrWrb5kHLGDlCfYB77POHxIeq7G_WDkLAeOrH2A2PMeRQdox4lPHIr7aPb5YJ4pvIyY0FauPFsbnRrqnevzcGD2jgpjCz8EixUKt-UsvBSWchKwSk60rKwcLbTAXqd3C_GM3_-PH0Yj-a-CuOA-UrTlEHCKScqingQA6ZxijXLSBiHWuOApJqRjKhUcZxJrmSqKeYJzTSLWBgM0GWXWzerrzXYVpTGKijcE7BaW8FxgnHipiOvOlI1K2sb0KJuTCmbjSBYbKsS26rEtirHXuxS12kJ2Z7868YB1x3wbQrY_J8kXkaL2S7S7xzGtvCzd8jmU8QsYJFYPk3Fcjrh47fHibgLfgGXf4Hl</recordid><startdate>201201</startdate><enddate>201201</enddate><creator>Miller-Hodges, Eve</creator><creator>Hohenstein, Peter</creator><general>John Wiley &amp; Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201201</creationdate><title>WT1 in disease: shifting the epithelial-mesenchymal balance</title><author>Miller-Hodges, Eve ; Hohenstein, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4637-cf2b7e89291c55936e026b0f7d1464ff031bf71d1cbc90da9cabf20982df75743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>cancer</topic><topic>Cardiovascular Diseases - genetics</topic><topic>Disease Models, Animal</topic><topic>Embryonic Development - genetics</topic><topic>EMT</topic><topic>Epithelial-Mesenchymal Transition - genetics</topic><topic>Epithelium - pathology</topic><topic>Genes, Wilms Tumor - physiology</topic><topic>Gonadal Dysgenesis, 46,XY - genetics</topic><topic>Humans</topic><topic>kidney</topic><topic>Kidney - embryology</topic><topic>Kidney Neoplasms - genetics</topic><topic>Kidney Neoplasms - pathology</topic><topic>Mesoderm - pathology</topic><topic>MET</topic><topic>Mice</topic><topic>Mutation - genetics</topic><topic>Oncogenes - physiology</topic><topic>podocyte</topic><topic>Regeneration - genetics</topic><topic>Wilms Tumor - genetics</topic><topic>Wilms Tumor - pathology</topic><topic>WT1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miller-Hodges, Eve</creatorcontrib><creatorcontrib>Hohenstein, Peter</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miller-Hodges, Eve</au><au>Hohenstein, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>WT1 in disease: shifting the epithelial-mesenchymal balance</atitle><jtitle>The Journal of pathology</jtitle><addtitle>J. Pathol</addtitle><date>2012-01</date><risdate>2012</risdate><volume>226</volume><issue>2</issue><spage>229</spage><epage>240</epage><pages>229-240</pages><issn>0022-3417</issn><eissn>1096-9896</eissn><abstract>WT1 is a versatile gene that controls transitions between the mesenchymal and epithelial state of cells in a tissue‐context dependent manner. As such, WT1 is indispensable for normal development of many organs and tissues. Uncontrolled epithelial to mesenchymal transition (EMT) is a hallmark of a diverse array of pathologies and disturbance of mesenchymal to epithelial transition (MET) has been associated with a number of developmental abnormalities. It is therefore not surprising that WT1 has been linked to many of these. Here we review the role of WT1 in proper control of the mesenchymal–epithelial balance of cells and discuss how far these roles can explain the role of WT1 in a variety of disease states. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley &amp; Sons, Ltd</pub><pmid>21959952</pmid><doi>10.1002/path.2977</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0022-3417
ispartof The Journal of pathology, 2012-01, Vol.226 (2), p.229-240
issn 0022-3417
1096-9896
language eng
recordid cdi_proquest_miscellaneous_908008908
source MEDLINE; Access via Wiley Online Library
subjects Animals
cancer
Cardiovascular Diseases - genetics
Disease Models, Animal
Embryonic Development - genetics
EMT
Epithelial-Mesenchymal Transition - genetics
Epithelium - pathology
Genes, Wilms Tumor - physiology
Gonadal Dysgenesis, 46,XY - genetics
Humans
kidney
Kidney - embryology
Kidney Neoplasms - genetics
Kidney Neoplasms - pathology
Mesoderm - pathology
MET
Mice
Mutation - genetics
Oncogenes - physiology
podocyte
Regeneration - genetics
Wilms Tumor - genetics
Wilms Tumor - pathology
WT1
title WT1 in disease: shifting the epithelial-mesenchymal balance
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T11%3A29%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=WT1%20in%20disease:%20shifting%20the%20epithelial-mesenchymal%20balance&rft.jtitle=The%20Journal%20of%20pathology&rft.au=Miller-Hodges,%20Eve&rft.date=2012-01&rft.volume=226&rft.issue=2&rft.spage=229&rft.epage=240&rft.pages=229-240&rft.issn=0022-3417&rft.eissn=1096-9896&rft_id=info:doi/10.1002/path.2977&rft_dat=%3Cproquest_cross%3E908008908%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=908008908&rft_id=info:pmid/21959952&rfr_iscdi=true