WT1 in disease: shifting the epithelial-mesenchymal balance
WT1 is a versatile gene that controls transitions between the mesenchymal and epithelial state of cells in a tissue‐context dependent manner. As such, WT1 is indispensable for normal development of many organs and tissues. Uncontrolled epithelial to mesenchymal transition (EMT) is a hallmark of a di...
Gespeichert in:
Veröffentlicht in: | The Journal of pathology 2012-01, Vol.226 (2), p.229-240 |
---|---|
Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 240 |
---|---|
container_issue | 2 |
container_start_page | 229 |
container_title | The Journal of pathology |
container_volume | 226 |
creator | Miller-Hodges, Eve Hohenstein, Peter |
description | WT1 is a versatile gene that controls transitions between the mesenchymal and epithelial state of cells in a tissue‐context dependent manner. As such, WT1 is indispensable for normal development of many organs and tissues. Uncontrolled epithelial to mesenchymal transition (EMT) is a hallmark of a diverse array of pathologies and disturbance of mesenchymal to epithelial transition (MET) has been associated with a number of developmental abnormalities. It is therefore not surprising that WT1 has been linked to many of these. Here we review the role of WT1 in proper control of the mesenchymal–epithelial balance of cells and discuss how far these roles can explain the role of WT1 in a variety of disease states. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. |
doi_str_mv | 10.1002/path.2977 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_908008908</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>908008908</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4637-cf2b7e89291c55936e026b0f7d1464ff031bf71d1cbc90da9cabf20982df75743</originalsourceid><addsrcrecordid>eNp1kM1OwzAQhC0EoqVw4AVQbohDiu38OIZTVWiLqIBDUSUuluOsiSFJQ5wK-va4SumNy85K-81oNQidEzwkGNPrWrb5kHLGDlCfYB77POHxIeq7G_WDkLAeOrH2A2PMeRQdox4lPHIr7aPb5YJ4pvIyY0FauPFsbnRrqnevzcGD2jgpjCz8EixUKt-UsvBSWchKwSk60rKwcLbTAXqd3C_GM3_-PH0Yj-a-CuOA-UrTlEHCKScqingQA6ZxijXLSBiHWuOApJqRjKhUcZxJrmSqKeYJzTSLWBgM0GWXWzerrzXYVpTGKijcE7BaW8FxgnHipiOvOlI1K2sb0KJuTCmbjSBYbKsS26rEtirHXuxS12kJ2Z7868YB1x3wbQrY_J8kXkaL2S7S7xzGtvCzd8jmU8QsYJFYPk3Fcjrh47fHibgLfgGXf4Hl</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>908008908</pqid></control><display><type>article</type><title>WT1 in disease: shifting the epithelial-mesenchymal balance</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Miller-Hodges, Eve ; Hohenstein, Peter</creator><creatorcontrib>Miller-Hodges, Eve ; Hohenstein, Peter</creatorcontrib><description>WT1 is a versatile gene that controls transitions between the mesenchymal and epithelial state of cells in a tissue‐context dependent manner. As such, WT1 is indispensable for normal development of many organs and tissues. Uncontrolled epithelial to mesenchymal transition (EMT) is a hallmark of a diverse array of pathologies and disturbance of mesenchymal to epithelial transition (MET) has been associated with a number of developmental abnormalities. It is therefore not surprising that WT1 has been linked to many of these. Here we review the role of WT1 in proper control of the mesenchymal–epithelial balance of cells and discuss how far these roles can explain the role of WT1 in a variety of disease states. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</description><identifier>ISSN: 0022-3417</identifier><identifier>EISSN: 1096-9896</identifier><identifier>DOI: 10.1002/path.2977</identifier><identifier>PMID: 21959952</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; cancer ; Cardiovascular Diseases - genetics ; Disease Models, Animal ; Embryonic Development - genetics ; EMT ; Epithelial-Mesenchymal Transition - genetics ; Epithelium - pathology ; Genes, Wilms Tumor - physiology ; Gonadal Dysgenesis, 46,XY - genetics ; Humans ; kidney ; Kidney - embryology ; Kidney Neoplasms - genetics ; Kidney Neoplasms - pathology ; Mesoderm - pathology ; MET ; Mice ; Mutation - genetics ; Oncogenes - physiology ; podocyte ; Regeneration - genetics ; Wilms Tumor - genetics ; Wilms Tumor - pathology ; WT1</subject><ispartof>The Journal of pathology, 2012-01, Vol.226 (2), p.229-240</ispartof><rights>Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4637-cf2b7e89291c55936e026b0f7d1464ff031bf71d1cbc90da9cabf20982df75743</citedby><cites>FETCH-LOGICAL-c4637-cf2b7e89291c55936e026b0f7d1464ff031bf71d1cbc90da9cabf20982df75743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpath.2977$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpath.2977$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21959952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miller-Hodges, Eve</creatorcontrib><creatorcontrib>Hohenstein, Peter</creatorcontrib><title>WT1 in disease: shifting the epithelial-mesenchymal balance</title><title>The Journal of pathology</title><addtitle>J. Pathol</addtitle><description>WT1 is a versatile gene that controls transitions between the mesenchymal and epithelial state of cells in a tissue‐context dependent manner. As such, WT1 is indispensable for normal development of many organs and tissues. Uncontrolled epithelial to mesenchymal transition (EMT) is a hallmark of a diverse array of pathologies and disturbance of mesenchymal to epithelial transition (MET) has been associated with a number of developmental abnormalities. It is therefore not surprising that WT1 has been linked to many of these. Here we review the role of WT1 in proper control of the mesenchymal–epithelial balance of cells and discuss how far these roles can explain the role of WT1 in a variety of disease states. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</description><subject>Animals</subject><subject>cancer</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Disease Models, Animal</subject><subject>Embryonic Development - genetics</subject><subject>EMT</subject><subject>Epithelial-Mesenchymal Transition - genetics</subject><subject>Epithelium - pathology</subject><subject>Genes, Wilms Tumor - physiology</subject><subject>Gonadal Dysgenesis, 46,XY - genetics</subject><subject>Humans</subject><subject>kidney</subject><subject>Kidney - embryology</subject><subject>Kidney Neoplasms - genetics</subject><subject>Kidney Neoplasms - pathology</subject><subject>Mesoderm - pathology</subject><subject>MET</subject><subject>Mice</subject><subject>Mutation - genetics</subject><subject>Oncogenes - physiology</subject><subject>podocyte</subject><subject>Regeneration - genetics</subject><subject>Wilms Tumor - genetics</subject><subject>Wilms Tumor - pathology</subject><subject>WT1</subject><issn>0022-3417</issn><issn>1096-9896</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1OwzAQhC0EoqVw4AVQbohDiu38OIZTVWiLqIBDUSUuluOsiSFJQ5wK-va4SumNy85K-81oNQidEzwkGNPrWrb5kHLGDlCfYB77POHxIeq7G_WDkLAeOrH2A2PMeRQdox4lPHIr7aPb5YJ4pvIyY0FauPFsbnRrqnevzcGD2jgpjCz8EixUKt-UsvBSWchKwSk60rKwcLbTAXqd3C_GM3_-PH0Yj-a-CuOA-UrTlEHCKScqingQA6ZxijXLSBiHWuOApJqRjKhUcZxJrmSqKeYJzTSLWBgM0GWXWzerrzXYVpTGKijcE7BaW8FxgnHipiOvOlI1K2sb0KJuTCmbjSBYbKsS26rEtirHXuxS12kJ2Z7868YB1x3wbQrY_J8kXkaL2S7S7xzGtvCzd8jmU8QsYJFYPk3Fcjrh47fHibgLfgGXf4Hl</recordid><startdate>201201</startdate><enddate>201201</enddate><creator>Miller-Hodges, Eve</creator><creator>Hohenstein, Peter</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201201</creationdate><title>WT1 in disease: shifting the epithelial-mesenchymal balance</title><author>Miller-Hodges, Eve ; Hohenstein, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4637-cf2b7e89291c55936e026b0f7d1464ff031bf71d1cbc90da9cabf20982df75743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>cancer</topic><topic>Cardiovascular Diseases - genetics</topic><topic>Disease Models, Animal</topic><topic>Embryonic Development - genetics</topic><topic>EMT</topic><topic>Epithelial-Mesenchymal Transition - genetics</topic><topic>Epithelium - pathology</topic><topic>Genes, Wilms Tumor - physiology</topic><topic>Gonadal Dysgenesis, 46,XY - genetics</topic><topic>Humans</topic><topic>kidney</topic><topic>Kidney - embryology</topic><topic>Kidney Neoplasms - genetics</topic><topic>Kidney Neoplasms - pathology</topic><topic>Mesoderm - pathology</topic><topic>MET</topic><topic>Mice</topic><topic>Mutation - genetics</topic><topic>Oncogenes - physiology</topic><topic>podocyte</topic><topic>Regeneration - genetics</topic><topic>Wilms Tumor - genetics</topic><topic>Wilms Tumor - pathology</topic><topic>WT1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miller-Hodges, Eve</creatorcontrib><creatorcontrib>Hohenstein, Peter</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miller-Hodges, Eve</au><au>Hohenstein, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>WT1 in disease: shifting the epithelial-mesenchymal balance</atitle><jtitle>The Journal of pathology</jtitle><addtitle>J. Pathol</addtitle><date>2012-01</date><risdate>2012</risdate><volume>226</volume><issue>2</issue><spage>229</spage><epage>240</epage><pages>229-240</pages><issn>0022-3417</issn><eissn>1096-9896</eissn><abstract>WT1 is a versatile gene that controls transitions between the mesenchymal and epithelial state of cells in a tissue‐context dependent manner. As such, WT1 is indispensable for normal development of many organs and tissues. Uncontrolled epithelial to mesenchymal transition (EMT) is a hallmark of a diverse array of pathologies and disturbance of mesenchymal to epithelial transition (MET) has been associated with a number of developmental abnormalities. It is therefore not surprising that WT1 has been linked to many of these. Here we review the role of WT1 in proper control of the mesenchymal–epithelial balance of cells and discuss how far these roles can explain the role of WT1 in a variety of disease states. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>21959952</pmid><doi>10.1002/path.2977</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0022-3417 |
ispartof | The Journal of pathology, 2012-01, Vol.226 (2), p.229-240 |
issn | 0022-3417 1096-9896 |
language | eng |
recordid | cdi_proquest_miscellaneous_908008908 |
source | MEDLINE; Access via Wiley Online Library |
subjects | Animals cancer Cardiovascular Diseases - genetics Disease Models, Animal Embryonic Development - genetics EMT Epithelial-Mesenchymal Transition - genetics Epithelium - pathology Genes, Wilms Tumor - physiology Gonadal Dysgenesis, 46,XY - genetics Humans kidney Kidney - embryology Kidney Neoplasms - genetics Kidney Neoplasms - pathology Mesoderm - pathology MET Mice Mutation - genetics Oncogenes - physiology podocyte Regeneration - genetics Wilms Tumor - genetics Wilms Tumor - pathology WT1 |
title | WT1 in disease: shifting the epithelial-mesenchymal balance |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T11%3A29%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=WT1%20in%20disease:%20shifting%20the%20epithelial-mesenchymal%20balance&rft.jtitle=The%20Journal%20of%20pathology&rft.au=Miller-Hodges,%20Eve&rft.date=2012-01&rft.volume=226&rft.issue=2&rft.spage=229&rft.epage=240&rft.pages=229-240&rft.issn=0022-3417&rft.eissn=1096-9896&rft_id=info:doi/10.1002/path.2977&rft_dat=%3Cproquest_cross%3E908008908%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=908008908&rft_id=info:pmid/21959952&rfr_iscdi=true |