Efficient Regioselective Three-Component Domino Synthesis of 3-(1,2,4-Triazol-5-yl)-1,3-thiazolidin-4-ones as Potent Antifungal and Antituberculosis Agents

In research for promising antibacterial and antifungal compounds, a series of 2‐aryl 3‐[1,2,4]triazol‐5‐yl 4‐thiazolidinones 1 were synthesized by a domino reaction of 5‐amino‐1H‐[1,2,4]triazoles 3, aromatic aldehydes, and α‐mercaptoacids in boiling toluene in the presence of molecular sieves 4 Å. O...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2011-12, Vol.344 (12), p.821-829
Hauptverfasser:	El Bialy, Serry A., Nagy, Maria M., Abdel-Rahman, Hamdy M.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Thiazolidinones 4]triazoles 5-Amino-1H- 5‐Amino‐1H‐[1,2,4]triazoles Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - pharmacology Antitubercular Agents - chemical synthesis Antitubercular Agents - pharmacology Antituberculosis agents Domino reaction Microbial Sensitivity Tests Structure-Activity Relationship Triazoles - chemical synthesis Triazoles - pharmacology
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