The cell cycle and cancer

Deregulation of the cell cycle underlies the aberrant cell proliferation that characterizes cancer and loss of cell cycle checkpoint control promotes genetic instability. During the past two decades, cancer genetics has shown that hyperactivating mutations in growth signalling networks, coupled to l...

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Veröffentlicht in:The Journal of pathology 2012-01, Vol.226 (2), p.352-364
Hauptverfasser: Williams, Gareth H, Stoeber, Kai
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container_title The Journal of pathology
container_volume 226
creator Williams, Gareth H
Stoeber, Kai
description Deregulation of the cell cycle underlies the aberrant cell proliferation that characterizes cancer and loss of cell cycle checkpoint control promotes genetic instability. During the past two decades, cancer genetics has shown that hyperactivating mutations in growth signalling networks, coupled to loss of function of tumour suppressor proteins, drives oncogenic proliferation. Gene expression profiling of these complex and redundant mitogenic pathways to identify prognostic and predictive signatures and their therapeutic targeting has, however, proved challenging. The cell cycle machinery, which acts as an integration point for information transduced through upstream signalling networks, represents an alternative target for diagnostic and therapeutic interventions. Analysis of the DNA replication initiation machinery and mitotic engine proteins in human tissues is now leading to the identification of novel biomarkers for cancer detection and prognostication, and is providing target validation for cell cycle‐directed therapies. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
doi_str_mv 10.1002/path.3022
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subjects Antineoplastic Agents - therapeutic use
biomarker
cancer
cell cycle
Cell Cycle - physiology
Cell Cycle Proteins - metabolism
DNA replication
DNA Replication - drug effects
DNA Replication - physiology
Early Detection of Cancer
Geminin
Humans
MCM
mitosis
Neoplasms - drug therapy
Neoplasms - pathology
phosphohistone
Phosphoprotein Phosphatases - metabolism
Phosphotransferases - metabolism
Signal Transduction - physiology
therapy
Treatment Outcome
title The cell cycle and cancer
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