Antinociceptive effects of spinally administered nociceptin/orphanin FQ and its N-terminal fragments on capsaicin-induced nociception
► Intrathecal injection of N/OFQ caused a dose-dependent antinociceptive effect. ► The N-terminal fragments of N/OFQ were antinociceptive with a potency lower than N/OFQ. ► Antinociceptive effect of N/OFQ (1–13) and (1–11) lasted longer than that of N/OFQ. ► N/OFQ (1–13)-induced antinociception is m...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2011-07, Vol.32 (7), p.1530-1535 |
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| creator | Katsuyama, Soh Mizoguchi, Hirokazu Komatsu, Takaaki Sakurada, Chikai Tsuzuki, Minoru Sakurada, Shinobu Sakurada, Tsukasa |
| description | ► Intrathecal injection of N/OFQ caused a dose-dependent antinociceptive effect. ► The N-terminal fragments of N/OFQ were antinociceptive with a potency lower than N/OFQ. ► Antinociceptive effect of N/OFQ (1–13) and (1–11) lasted longer than that of N/OFQ. ► N/OFQ (1–13)-induced antinociception is mediated through spinal NOP receptors.
Nociceptin/orphanin FQ (N/OFQ), the endogenous ligand for the N/OFQ peptide (NOP) receptors, has been shown to be metabolized into some fragments. We examined to determine whether intrathecal (i.t.) N/OFQ (1–13), (1–11) and (1–7) have antinociceptive activity in the pain-related behavior after intraplantar injection of capsaicin. The i.t. administration of N/OFQ (0.3–1.2nmol) produced an appreciable and dose-dependent inhibition of capsaicin-induced paw-licking/biting response. The N-terminal fragments of N/OFQ, (1–13) and (1–11), were antinociceptive with a potency lower than N/OFQ. Calculated ID50 values (nmol, i.t.) were 0.83 for N/OFQ, 2.5 for N/OFQ (1–13) and 4.75 for N/OFQ (1–11), respectively. The time-course effect revealed that the antinociceptive effects of these N-terminal fragments lasted longer than those of N/OFQ. Removal of amino acids down to N/OFQ (1–7) led to be less potent than N/OFQ and its fragments, (1–13) and (1–11). Antinociception induced by N/OFQ or N/OFQ (1–13) was reversed significantly by i.t. co-injection of [Nphe1]N/OFQ (1–13)NH2, a peptidergic antagonist for NOP receptors, whereas i.t. injection of the antagonist did not interfere with the action of N/OFQ (1–11) and (1–7). Pretreatment with the opioid receptor antagonist naloxone hydrochloride did not affect the antinociception induced by N/OFQ and its N-terminal fragments. These results suggest that N-terminal fragments of N/OFQ are active metabolites and may modulate the antinociceptive effect of N/OFQ in the spinal cord. The results also indicate that N/OFQ (1–13) still possess antinociceptive activity through NOP receptors. |
| doi_str_mv | 10.1016/j.peptides.2011.05.028 |
| format | Article |
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Nociceptin/orphanin FQ (N/OFQ), the endogenous ligand for the N/OFQ peptide (NOP) receptors, has been shown to be metabolized into some fragments. We examined to determine whether intrathecal (i.t.) N/OFQ (1–13), (1–11) and (1–7) have antinociceptive activity in the pain-related behavior after intraplantar injection of capsaicin. The i.t. administration of N/OFQ (0.3–1.2nmol) produced an appreciable and dose-dependent inhibition of capsaicin-induced paw-licking/biting response. The N-terminal fragments of N/OFQ, (1–13) and (1–11), were antinociceptive with a potency lower than N/OFQ. Calculated ID50 values (nmol, i.t.) were 0.83 for N/OFQ, 2.5 for N/OFQ (1–13) and 4.75 for N/OFQ (1–11), respectively. The time-course effect revealed that the antinociceptive effects of these N-terminal fragments lasted longer than those of N/OFQ. Removal of amino acids down to N/OFQ (1–7) led to be less potent than N/OFQ and its fragments, (1–13) and (1–11). Antinociception induced by N/OFQ or N/OFQ (1–13) was reversed significantly by i.t. co-injection of [Nphe1]N/OFQ (1–13)NH2, a peptidergic antagonist for NOP receptors, whereas i.t. injection of the antagonist did not interfere with the action of N/OFQ (1–11) and (1–7). Pretreatment with the opioid receptor antagonist naloxone hydrochloride did not affect the antinociception induced by N/OFQ and its N-terminal fragments. These results suggest that N-terminal fragments of N/OFQ are active metabolites and may modulate the antinociceptive effect of N/OFQ in the spinal cord. The results also indicate that N/OFQ (1–13) still possess antinociceptive activity through NOP receptors.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/j.peptides.2011.05.028</identifier><identifier>PMID: 21672568</identifier><identifier>CODEN: PPTDD5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Amino acids ; analgesic effect ; Analgesics ; Analgesics - chemical synthesis ; Analgesics - pharmacology ; Analgesics - therapeutic use ; Animals ; antagonists ; Antinociception ; Behavior, Animal ; Biological and medical sciences ; capsaicin ; Capsaicin - adverse effects ; Capsaicin - pharmacology ; Capsaicin-induced nociception ; dose response ; Dose-Response Relationship, Drug ; Drug Interactions ; Fragments ; Fundamental and applied biological sciences. Psychology ; Inhibitory Concentration 50 ; injection ; Injections, Spinal ; Injections, Subcutaneous ; Ligands ; Male ; Mathematical analysis ; Medical sciences ; Metabolites ; Mice ; Mice, Inbred Strains ; N-Terminal fragments of N/OFQ ; N/OFQ peptide (NOP) receptor ; naloxone ; Naloxone - pharmacology ; Narcotic Antagonists - pharmacology ; Neuropharmacology ; Nociceptin ; Nociceptin/orphanin FQ (N/OFQ) ; nociception ; Opioid Peptides - chemical synthesis ; Opioid Peptides - pharmacology ; Opioid Peptides - therapeutic use ; Pain - drug therapy ; Pain - physiopathology ; Pain Measurement - drug effects ; Pain Measurement - psychology ; Pain Perception - drug effects ; Pain Perception - physiology ; Peptide Fragments - chemical synthesis ; Peptide Fragments - pharmacology ; Peptide Fragments - therapeutic use ; Peptides ; Pharmacology. Drug treatments ; Receptors ; Receptors, Opioid - metabolism ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Spinal cord ; Spinal Cord - drug effects ; Spinal Cord - physiology ; Structure-Activity Relationship ; Vertebrates: endocrinology ; Vertebrates: nervous system and sense organs</subject><ispartof>Peptides (New York, N.Y. : 1980), 2011-07, Vol.32 (7), p.1530-1535</ispartof><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c552t-b7c16e9966c2bdbd72fc6e845140cc7bcffd21ade20a680a0f8353cf7f41a9313</citedby><cites>FETCH-LOGICAL-c552t-b7c16e9966c2bdbd72fc6e845140cc7bcffd21ade20a680a0f8353cf7f41a9313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0196978111002245$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24388107$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21672568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Katsuyama, Soh</creatorcontrib><creatorcontrib>Mizoguchi, Hirokazu</creatorcontrib><creatorcontrib>Komatsu, Takaaki</creatorcontrib><creatorcontrib>Sakurada, Chikai</creatorcontrib><creatorcontrib>Tsuzuki, Minoru</creatorcontrib><creatorcontrib>Sakurada, Shinobu</creatorcontrib><creatorcontrib>Sakurada, Tsukasa</creatorcontrib><title>Antinociceptive effects of spinally administered nociceptin/orphanin FQ and its N-terminal fragments on capsaicin-induced nociception</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>► Intrathecal injection of N/OFQ caused a dose-dependent antinociceptive effect. ► The N-terminal fragments of N/OFQ were antinociceptive with a potency lower than N/OFQ. ► Antinociceptive effect of N/OFQ (1–13) and (1–11) lasted longer than that of N/OFQ. ► N/OFQ (1–13)-induced antinociception is mediated through spinal NOP receptors.
Nociceptin/orphanin FQ (N/OFQ), the endogenous ligand for the N/OFQ peptide (NOP) receptors, has been shown to be metabolized into some fragments. We examined to determine whether intrathecal (i.t.) N/OFQ (1–13), (1–11) and (1–7) have antinociceptive activity in the pain-related behavior after intraplantar injection of capsaicin. The i.t. administration of N/OFQ (0.3–1.2nmol) produced an appreciable and dose-dependent inhibition of capsaicin-induced paw-licking/biting response. The N-terminal fragments of N/OFQ, (1–13) and (1–11), were antinociceptive with a potency lower than N/OFQ. Calculated ID50 values (nmol, i.t.) were 0.83 for N/OFQ, 2.5 for N/OFQ (1–13) and 4.75 for N/OFQ (1–11), respectively. The time-course effect revealed that the antinociceptive effects of these N-terminal fragments lasted longer than those of N/OFQ. Removal of amino acids down to N/OFQ (1–7) led to be less potent than N/OFQ and its fragments, (1–13) and (1–11). Antinociception induced by N/OFQ or N/OFQ (1–13) was reversed significantly by i.t. co-injection of [Nphe1]N/OFQ (1–13)NH2, a peptidergic antagonist for NOP receptors, whereas i.t. injection of the antagonist did not interfere with the action of N/OFQ (1–11) and (1–7). Pretreatment with the opioid receptor antagonist naloxone hydrochloride did not affect the antinociception induced by N/OFQ and its N-terminal fragments. These results suggest that N-terminal fragments of N/OFQ are active metabolites and may modulate the antinociceptive effect of N/OFQ in the spinal cord. The results also indicate that N/OFQ (1–13) still possess antinociceptive activity through NOP receptors.</description><subject>Amino acids</subject><subject>analgesic effect</subject><subject>Analgesics</subject><subject>Analgesics - chemical synthesis</subject><subject>Analgesics - pharmacology</subject><subject>Analgesics - therapeutic use</subject><subject>Animals</subject><subject>antagonists</subject><subject>Antinociception</subject><subject>Behavior, Animal</subject><subject>Biological and medical sciences</subject><subject>capsaicin</subject><subject>Capsaicin - adverse effects</subject><subject>Capsaicin - pharmacology</subject><subject>Capsaicin-induced nociception</subject><subject>dose response</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Interactions</subject><subject>Fragments</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Inhibitory Concentration 50</subject><subject>injection</subject><subject>Injections, Spinal</subject><subject>Injections, Subcutaneous</subject><subject>Ligands</subject><subject>Male</subject><subject>Mathematical analysis</subject><subject>Medical sciences</subject><subject>Metabolites</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>N-Terminal fragments of N/OFQ</subject><subject>N/OFQ peptide (NOP) receptor</subject><subject>naloxone</subject><subject>Naloxone - pharmacology</subject><subject>Narcotic Antagonists - pharmacology</subject><subject>Neuropharmacology</subject><subject>Nociceptin</subject><subject>Nociceptin/orphanin FQ (N/OFQ)</subject><subject>nociception</subject><subject>Opioid Peptides - chemical synthesis</subject><subject>Opioid Peptides - pharmacology</subject><subject>Opioid Peptides - therapeutic use</subject><subject>Pain - drug therapy</subject><subject>Pain - physiopathology</subject><subject>Pain Measurement - drug effects</subject><subject>Pain Measurement - psychology</subject><subject>Pain Perception - drug effects</subject><subject>Pain Perception - physiology</subject><subject>Peptide Fragments - chemical synthesis</subject><subject>Peptide Fragments - pharmacology</subject><subject>Peptide Fragments - therapeutic use</subject><subject>Peptides</subject><subject>Pharmacology. Drug treatments</subject><subject>Receptors</subject><subject>Receptors, Opioid - metabolism</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Spinal cord</subject><subject>Spinal Cord - drug effects</subject><subject>Spinal Cord - physiology</subject><subject>Structure-Activity Relationship</subject><subject>Vertebrates: endocrinology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1TAQhi0EoofCKxRvULtJ6nESX3ZUFQWkCoSga8vxpfgocYKdU6kPwHvX0TktrGA1m-__ZzQfQidAaiDAzrf17OYlWJdrSgBq0tWEimdoA4I3VQdMPkcbApJVkgs4Qq9y3hJC2laKl-iIAuO0Y2KDfl_EJcTJBLPW3TnsvHdmyXjyOM8h6mG4x9qOIYa8uOQsfoLj-ZTmnzqGiK--YR0tDiX3pSrYuAaxT_p2dHEti9joOetgQqxCtDvzd9EUX6MXXg_ZvTnMY3Rz9eHH5afq-uvHz5cX15XpOrpUPTfAnJSMGdrb3nLqDXOi7aAlxvDeeG8paOso0UwQTbxousZ47lvQsoHmGJ3ue-c0_dq5vKgxZOOGQUc37bKShMtG0pYW8uyfJHBGgVIGbUHZHjVpyjk5r-YURp3uFRC1ylJb9ShLrbIU6VSRVYInhx27fnT2KfZopwDvDoDORg_ln9GE_IdrGyGA8MK93XNeT0rfpsLcfC-bWDEODaGkEO_3hCvfvQsuqWyCi0VDSEW3slP437UPmQPCkg</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Katsuyama, Soh</creator><creator>Mizoguchi, Hirokazu</creator><creator>Komatsu, Takaaki</creator><creator>Sakurada, Chikai</creator><creator>Tsuzuki, Minoru</creator><creator>Sakurada, Shinobu</creator><creator>Sakurada, Tsukasa</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>20110701</creationdate><title>Antinociceptive effects of spinally administered nociceptin/orphanin FQ and its N-terminal fragments on capsaicin-induced nociception</title><author>Katsuyama, Soh ; Mizoguchi, Hirokazu ; Komatsu, Takaaki ; Sakurada, Chikai ; Tsuzuki, Minoru ; Sakurada, Shinobu ; Sakurada, Tsukasa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c552t-b7c16e9966c2bdbd72fc6e845140cc7bcffd21ade20a680a0f8353cf7f41a9313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Amino acids</topic><topic>analgesic effect</topic><topic>Analgesics</topic><topic>Analgesics - chemical synthesis</topic><topic>Analgesics - pharmacology</topic><topic>Analgesics - therapeutic use</topic><topic>Animals</topic><topic>antagonists</topic><topic>Antinociception</topic><topic>Behavior, Animal</topic><topic>Biological and medical sciences</topic><topic>capsaicin</topic><topic>Capsaicin - adverse effects</topic><topic>Capsaicin - pharmacology</topic><topic>Capsaicin-induced nociception</topic><topic>dose response</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Interactions</topic><topic>Fragments</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Inhibitory Concentration 50</topic><topic>injection</topic><topic>Injections, Spinal</topic><topic>Injections, Subcutaneous</topic><topic>Ligands</topic><topic>Male</topic><topic>Mathematical analysis</topic><topic>Medical sciences</topic><topic>Metabolites</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>N-Terminal fragments of N/OFQ</topic><topic>N/OFQ peptide (NOP) receptor</topic><topic>naloxone</topic><topic>Naloxone - pharmacology</topic><topic>Narcotic Antagonists - pharmacology</topic><topic>Neuropharmacology</topic><topic>Nociceptin</topic><topic>Nociceptin/orphanin FQ (N/OFQ)</topic><topic>nociception</topic><topic>Opioid Peptides - chemical synthesis</topic><topic>Opioid Peptides - pharmacology</topic><topic>Opioid Peptides - therapeutic use</topic><topic>Pain - drug therapy</topic><topic>Pain - physiopathology</topic><topic>Pain Measurement - drug effects</topic><topic>Pain Measurement - psychology</topic><topic>Pain Perception - drug effects</topic><topic>Pain Perception - physiology</topic><topic>Peptide Fragments - chemical synthesis</topic><topic>Peptide Fragments - pharmacology</topic><topic>Peptide Fragments - therapeutic use</topic><topic>Peptides</topic><topic>Pharmacology. Drug treatments</topic><topic>Receptors</topic><topic>Receptors, Opioid - metabolism</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Spinal cord</topic><topic>Spinal Cord - drug effects</topic><topic>Spinal Cord - physiology</topic><topic>Structure-Activity Relationship</topic><topic>Vertebrates: endocrinology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Katsuyama, Soh</creatorcontrib><creatorcontrib>Mizoguchi, Hirokazu</creatorcontrib><creatorcontrib>Komatsu, Takaaki</creatorcontrib><creatorcontrib>Sakurada, Chikai</creatorcontrib><creatorcontrib>Tsuzuki, Minoru</creatorcontrib><creatorcontrib>Sakurada, Shinobu</creatorcontrib><creatorcontrib>Sakurada, Tsukasa</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Katsuyama, Soh</au><au>Mizoguchi, Hirokazu</au><au>Komatsu, Takaaki</au><au>Sakurada, Chikai</au><au>Tsuzuki, Minoru</au><au>Sakurada, Shinobu</au><au>Sakurada, Tsukasa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antinociceptive effects of spinally administered nociceptin/orphanin FQ and its N-terminal fragments on capsaicin-induced nociception</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>32</volume><issue>7</issue><spage>1530</spage><epage>1535</epage><pages>1530-1535</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><coden>PPTDD5</coden><abstract>► Intrathecal injection of N/OFQ caused a dose-dependent antinociceptive effect. ► The N-terminal fragments of N/OFQ were antinociceptive with a potency lower than N/OFQ. ► Antinociceptive effect of N/OFQ (1–13) and (1–11) lasted longer than that of N/OFQ. ► N/OFQ (1–13)-induced antinociception is mediated through spinal NOP receptors.
Nociceptin/orphanin FQ (N/OFQ), the endogenous ligand for the N/OFQ peptide (NOP) receptors, has been shown to be metabolized into some fragments. We examined to determine whether intrathecal (i.t.) N/OFQ (1–13), (1–11) and (1–7) have antinociceptive activity in the pain-related behavior after intraplantar injection of capsaicin. The i.t. administration of N/OFQ (0.3–1.2nmol) produced an appreciable and dose-dependent inhibition of capsaicin-induced paw-licking/biting response. The N-terminal fragments of N/OFQ, (1–13) and (1–11), were antinociceptive with a potency lower than N/OFQ. Calculated ID50 values (nmol, i.t.) were 0.83 for N/OFQ, 2.5 for N/OFQ (1–13) and 4.75 for N/OFQ (1–11), respectively. The time-course effect revealed that the antinociceptive effects of these N-terminal fragments lasted longer than those of N/OFQ. Removal of amino acids down to N/OFQ (1–7) led to be less potent than N/OFQ and its fragments, (1–13) and (1–11). Antinociception induced by N/OFQ or N/OFQ (1–13) was reversed significantly by i.t. co-injection of [Nphe1]N/OFQ (1–13)NH2, a peptidergic antagonist for NOP receptors, whereas i.t. injection of the antagonist did not interfere with the action of N/OFQ (1–11) and (1–7). Pretreatment with the opioid receptor antagonist naloxone hydrochloride did not affect the antinociception induced by N/OFQ and its N-terminal fragments. These results suggest that N-terminal fragments of N/OFQ are active metabolites and may modulate the antinociceptive effect of N/OFQ in the spinal cord. The results also indicate that N/OFQ (1–13) still possess antinociceptive activity through NOP receptors.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21672568</pmid><doi>10.1016/j.peptides.2011.05.028</doi><tpages>6</tpages></addata></record> |
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| ispartof | Peptides (New York, N.Y. : 1980), 2011-07, Vol.32 (7), p.1530-1535 |
| issn | 0196-9781 1873-5169 |
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| recordid | cdi_proquest_miscellaneous_907939242 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amino acids analgesic effect Analgesics Analgesics - chemical synthesis Analgesics - pharmacology Analgesics - therapeutic use Animals antagonists Antinociception Behavior, Animal Biological and medical sciences capsaicin Capsaicin - adverse effects Capsaicin - pharmacology Capsaicin-induced nociception dose response Dose-Response Relationship, Drug Drug Interactions Fragments Fundamental and applied biological sciences. Psychology Inhibitory Concentration 50 injection Injections, Spinal Injections, Subcutaneous Ligands Male Mathematical analysis Medical sciences Metabolites Mice Mice, Inbred Strains N-Terminal fragments of N/OFQ N/OFQ peptide (NOP) receptor naloxone Naloxone - pharmacology Narcotic Antagonists - pharmacology Neuropharmacology Nociceptin Nociceptin/orphanin FQ (N/OFQ) nociception Opioid Peptides - chemical synthesis Opioid Peptides - pharmacology Opioid Peptides - therapeutic use Pain - drug therapy Pain - physiopathology Pain Measurement - drug effects Pain Measurement - psychology Pain Perception - drug effects Pain Perception - physiology Peptide Fragments - chemical synthesis Peptide Fragments - pharmacology Peptide Fragments - therapeutic use Peptides Pharmacology. Drug treatments Receptors Receptors, Opioid - metabolism Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal cord Spinal Cord - drug effects Spinal Cord - physiology Structure-Activity Relationship Vertebrates: endocrinology Vertebrates: nervous system and sense organs |
| title | Antinociceptive effects of spinally administered nociceptin/orphanin FQ and its N-terminal fragments on capsaicin-induced nociception |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T03%3A19%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antinociceptive%20effects%20of%20spinally%20administered%20nociceptin/orphanin%20FQ%20and%20its%20N-terminal%20fragments%20on%20capsaicin-induced%20nociception&rft.jtitle=Peptides%20(New%20York,%20N.Y.%20:%201980)&rft.au=Katsuyama,%20Soh&rft.date=2011-07-01&rft.volume=32&rft.issue=7&rft.spage=1530&rft.epage=1535&rft.pages=1530-1535&rft.issn=0196-9781&rft.eissn=1873-5169&rft.coden=PPTDD5&rft_id=info:doi/10.1016/j.peptides.2011.05.028&rft_dat=%3Cproquest_cross%3E907939242%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1762122614&rft_id=info:pmid/21672568&rft_els_id=S0196978111002245&rfr_iscdi=true |