Chromatin "Prepattern" and Histone Modifiers in a Fate Choice for Liver and Pancreas

Transcriptionally silent genes can be marked by histone modifications and regulatory proteins that indicate the genes' potential to be activated. Such marks have been identified in pluripotent cells, but it is unknown how such marks occur in descendant, multipotent embryonic cells that have res...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2011-05, Vol.332 (6032), p.963-966
Hauptverfasser:	Xu, Cheng-Ran, Cole, Philip A., Meyers, David J., Kormish, Jay, Dent, Sharon, Zaret, Kenneth S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Biological and medical sciences Bone Morphogenetic Proteins - metabolism Cell Culture Techniques Cell Differentiation Cell differentiation, maturation, development, hematopoiesis Cell physiology Cell Separation Cellular biology Chromatin Chromatin - metabolism Chromatin Immunoprecipitation Developmental biology Embryonic cells Embryonic Development Embryonic Induction Embryonic stem cells Embryos Endoderm Endoderm - cytology Enhancer of Zeste Homolog 2 Protein Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Hepatocytes - cytology Histone-Lysine N-Methyltransferase - metabolism Histones - metabolism Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Liver Liver - cytology Liver - embryology Liver - metabolism Mice Molecular and cellular biology Multipotent stem cells Multipotent Stem Cells - cytology Multipotent Stem Cells - metabolism p300-CBP Transcription Factors - antagonists & inhibitors p300-CBP Transcription Factors - genetics p300-CBP Transcription Factors - metabolism Pancreas Pancreas - cytology Pancreas - embryology Pancreas - metabolism Pluripotent stem cells Polycomb Repressive Complex 2 Protein Processing, Post-Translational Proteins Regulatory Elements, Transcriptional Rodents Signal Transduction Stem cells Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors - metabolism
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