Alteration of microRNA expression correlates to fatty acid-mediated insulin resistance in mouse myoblasts

As new regulators at the post-transcriptional level, microRNAs (miRNAs) are non-coding 19-22 nucleotide RNA molecules that are believed to regulate the expression of thousands of genes. Since the monounsaturated fatty acid oleate can reverse insulin resistance induced by the saturated fatty acid pal...

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Veröffentlicht in:	Molecular bioSystems 2011-01, Vol.7 (3), p.871-877
Hauptverfasser:	Li, Zhen-Ya, Na, Hui-Min, Peng, Gong, Pu, Jing, Liu, Pingsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Disease Models, Animal Insulin Receptor Substrate Proteins - antagonists & inhibitors Insulin Receptor Substrate Proteins - genetics Insulin Receptor Substrate Proteins - metabolism Insulin Resistance Mice MicroRNAs - genetics MicroRNAs - metabolism Myoblasts - drug effects Myoblasts - metabolism Palmitates - metabolism Palmitates - pharmacology Phosphorylation Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Rats Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - drug effects
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