GABA and Dopamine Release from Different Brain Regions in Mice with Chronic Exposure to Organophosphate Methamidophos
Organophosphates such as methamidophos, usually used in the agricultural field, have harmful effects on humans. Exposures to insecticides has been associated with many disorders, including damage to the central and peripheral nervous system. Chronic exposure to organophosphates may lead to persisten...
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| Veröffentlicht in: | Journal of Toxicologic Pathology 2011, Vol.24 (3), p.163-168 |
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| creator | Blanca Rosa Noriega-Ortega Ernesto Armienta-Aldana Jose Angel Cervantes-Pompa Eduardo Armienta-Aldana Enrique Hernandez-Ruiz Veronica Chaparro-Huerta Alejandro Bravo-Cuellar Carlos Beas-Zarate |
| description | Organophosphates such as methamidophos, usually used in the agricultural field, have harmful effects on humans. Exposures to insecticides has been associated with many disorders, including damage to the central and peripheral nervous system. Chronic exposure to organophosphates may lead to persistent neurological and neurobehavioral effects. This study was conducted to determine the effect of methamidophos on [3H]-dopamine (DA) and gamma aminobutyric acid (GABA) release from different brain regions after chronic exposure to it for 3, 6 or 9 months. After a six-month methamidophos treatment, the mice showed high susceptibility to convulsive seizures and a reduction in stimulated gamma aminobutyric acid release from the cerebral cortex and hippocampal slices, whereas stimulated (DA) release was slightly decreased from the striatum after three months of methamidophos exposure. The results indicate changes in gamma aminobutyric acid and dopamine neurotransmission, suggesting a specific neuronal damage. (DOI:10.1293/tox.24.163;J Toxicol Pathol 2011;24:163.168) |
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Exposures to insecticides has been associated with many disorders, including damage to the central and peripheral nervous system. Chronic exposure to organophosphates may lead to persistent neurological and neurobehavioral effects. This study was conducted to determine the effect of methamidophos on [3H]-dopamine (DA) and gamma aminobutyric acid (GABA) release from different brain regions after chronic exposure to it for 3, 6 or 9 months. After a six-month methamidophos treatment, the mice showed high susceptibility to convulsive seizures and a reduction in stimulated gamma aminobutyric acid release from the cerebral cortex and hippocampal slices, whereas stimulated (DA) release was slightly decreased from the striatum after three months of methamidophos exposure. The results indicate changes in gamma aminobutyric acid and dopamine neurotransmission, suggesting a specific neuronal damage. (DOI:10.1293/tox.24.163;J Toxicol Pathol 2011;24:163.168)</description><identifier>ISSN: 0914-9198</identifier><identifier>ISSN: 1881-915X</identifier><identifier>EISSN: 1881-915X</identifier><language>jpn</language><publisher>The Japanese Society of Toxicologic Pathology</publisher><subject>Brain slice preparation ; Chronic exposure ; Cortex ; Dopamine ; gamma -Aminobutyric acid ; Insecticides ; methamidophos ; Neostriatum ; Neurotransmission ; organophosphates ; Peripheral nervous system ; Pesticides ; Seizures</subject><ispartof>Journal of Toxicologic Pathology, 2011, Vol.24 (3), p.163-168</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024</link.rule.ids></links><search><creatorcontrib>Blanca Rosa Noriega-Ortega</creatorcontrib><creatorcontrib>Ernesto Armienta-Aldana</creatorcontrib><creatorcontrib>Jose Angel Cervantes-Pompa</creatorcontrib><creatorcontrib>Eduardo Armienta-Aldana</creatorcontrib><creatorcontrib>Enrique Hernandez-Ruiz</creatorcontrib><creatorcontrib>Veronica Chaparro-Huerta</creatorcontrib><creatorcontrib>Alejandro Bravo-Cuellar</creatorcontrib><creatorcontrib>Carlos Beas-Zarate</creatorcontrib><creatorcontrib>Facultad de Medicina</creatorcontrib><creatorcontrib>Centro Universitario de Ciencias de la Salud (CUCS</creatorcontrib><creatorcontrib>Universidad Autonoma de Sinaloa(UAS</creatorcontrib><creatorcontrib>Facultad de Ciencias Quimico-Biologicas</creatorcontrib><creatorcontrib>Instituto Mexicano del Seguro Social (IMSS</creatorcontrib><creatorcontrib>Division de Inmunologia</creatorcontrib><creatorcontrib>Departamento de Biologia Celular y Molecular</creatorcontrib><creatorcontrib>Departamento de Farmacologia</creatorcontrib><creatorcontrib>Centro Universitario de Ciencias Biologicas y Agropecuarias (CUCBA</creatorcontrib><creatorcontrib>Laboratorio de Neurobiologia Celular y Molecular</creatorcontrib><creatorcontrib>Division de Neurociencias</creatorcontrib><creatorcontrib>Laboratorio de Inmunologia de los Tumores</creatorcontrib><creatorcontrib>Universidad de Guadalajara (U de G</creatorcontrib><creatorcontrib>Centro de Investigacion Biomedica de Occidente (CIBO</creatorcontrib><creatorcontrib>Universidad Autonoma de Sinaloa (UAS</creatorcontrib><title>GABA and Dopamine Release from Different Brain Regions in Mice with Chronic Exposure to Organophosphate Methamidophos</title><title>Journal of Toxicologic Pathology</title><description>Organophosphates such as methamidophos, usually used in the agricultural field, have harmful effects on humans. Exposures to insecticides has been associated with many disorders, including damage to the central and peripheral nervous system. Chronic exposure to organophosphates may lead to persistent neurological and neurobehavioral effects. This study was conducted to determine the effect of methamidophos on [3H]-dopamine (DA) and gamma aminobutyric acid (GABA) release from different brain regions after chronic exposure to it for 3, 6 or 9 months. After a six-month methamidophos treatment, the mice showed high susceptibility to convulsive seizures and a reduction in stimulated gamma aminobutyric acid release from the cerebral cortex and hippocampal slices, whereas stimulated (DA) release was slightly decreased from the striatum after three months of methamidophos exposure. The results indicate changes in gamma aminobutyric acid and dopamine neurotransmission, suggesting a specific neuronal damage. (DOI:10.1293/tox.24.163;J Toxicol Pathol 2011;24:163.168)</description><subject>Brain slice preparation</subject><subject>Chronic exposure</subject><subject>Cortex</subject><subject>Dopamine</subject><subject>gamma -Aminobutyric acid</subject><subject>Insecticides</subject><subject>methamidophos</subject><subject>Neostriatum</subject><subject>Neurotransmission</subject><subject>organophosphates</subject><subject>Peripheral nervous system</subject><subject>Pesticides</subject><subject>Seizures</subject><issn>0914-9198</issn><issn>1881-915X</issn><issn>1881-915X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9UE1LAzEQXUTBWv0PuemlkGyym-TYL6tgKYiCtyXdTLopu8ma7GJ_vqH17GHee8y8eTBzlU2IEGQmSfF1nU2wJCxpKW6zuxiPGOccF3SSjZv5Yo6U02jle9VZB-gdWlARkAm-QytrDARwA1oEZV0aHqx3ESW5tTWgHzs0aNkE72yN1qfexzEAGjzahYNyvm987Bs1ANrC0KR8fW7dZzdGtREe_niafT6vP5Yvs7fd5nU5f5t1REo5o0xKbKAssckLjUuaU6wxN8DJPtcgCmYw7GtKcqaZMIImMIwVJRZGl4rTafZ4ye2D_x4hDlVnYw1tqxz4MVYScyILTGRyPv3rJDiFE84ZTtbNxdqBtrVqvWvT26qjH4NLx1Ra08GfelXlmJAqfTrtJEpFyjMIUvBccEF_Abs_fkc</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Blanca Rosa Noriega-Ortega</creator><creator>Ernesto Armienta-Aldana</creator><creator>Jose Angel Cervantes-Pompa</creator><creator>Eduardo Armienta-Aldana</creator><creator>Enrique Hernandez-Ruiz</creator><creator>Veronica Chaparro-Huerta</creator><creator>Alejandro Bravo-Cuellar</creator><creator>Carlos Beas-Zarate</creator><general>The Japanese Society of Toxicologic Pathology</general><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>2011</creationdate><title>GABA and Dopamine Release from Different Brain Regions in Mice with Chronic Exposure to Organophosphate Methamidophos</title><author>Blanca Rosa Noriega-Ortega ; 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Exposures to insecticides has been associated with many disorders, including damage to the central and peripheral nervous system. Chronic exposure to organophosphates may lead to persistent neurological and neurobehavioral effects. This study was conducted to determine the effect of methamidophos on [3H]-dopamine (DA) and gamma aminobutyric acid (GABA) release from different brain regions after chronic exposure to it for 3, 6 or 9 months. After a six-month methamidophos treatment, the mice showed high susceptibility to convulsive seizures and a reduction in stimulated gamma aminobutyric acid release from the cerebral cortex and hippocampal slices, whereas stimulated (DA) release was slightly decreased from the striatum after three months of methamidophos exposure. The results indicate changes in gamma aminobutyric acid and dopamine neurotransmission, suggesting a specific neuronal damage. (DOI:10.1293/tox.24.163;J Toxicol Pathol 2011;24:163.168)</abstract><pub>The Japanese Society of Toxicologic Pathology</pub><tpages>6</tpages></addata></record> |
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| ispartof | Journal of Toxicologic Pathology, 2011, Vol.24 (3), p.163-168 |
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| source | J-STAGE Free; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Brain slice preparation Chronic exposure Cortex Dopamine gamma -Aminobutyric acid Insecticides methamidophos Neostriatum Neurotransmission organophosphates Peripheral nervous system Pesticides Seizures |
| title | GABA and Dopamine Release from Different Brain Regions in Mice with Chronic Exposure to Organophosphate Methamidophos |
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