Vascular endothelial growth factor and platelet derived growth factor modulates the glial response to a cortical stab injury

Abstract Traumatic injury to the brain initiates an increase in astrocyte and microglial infiltration as part of an inflammatory response to injury. Increased astrogliosis around the injury impedes regeneration of axons through the injury, while activated microglia release inflammatory mediators. Th...

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Veröffentlicht in:	Neuroscience 2011-09, Vol.192, p.652-660
Hauptverfasser:	Norazit, A, Nguyen, M.N, Dickson, C.G.M, Tuxworth, G, Goss, B, Mackay-Sim, A, Meedeniya, A.C.B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals astrogliosis Biological and medical sciences Brain Injuries - pathology brain injury Fundamental and applied biological sciences. Psychology Inflammation - drug therapy Male microglial response Microscopy, Fluorescence Neuroglia - drug effects Neuroglia - pathology Neurology platelet derived growth factor Platelet-Derived Growth Factor - pharmacology Rats Rats, Sprague-Dawley vascular endothelial growth factor Vascular Endothelial Growth Factor A - pharmacology Vertebrates: nervous system and sense organs Wounds, Stab - pathology
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