In-vivo cancer cell destruction using porous silicon nanoparticles
In-vivo animal tests were performed to investigate the feasibility of photothermal therapy based on porous silicon nanoparticles (PSiNPs) in combination with a near-infrared (NIR) laser. The in-vivo animal test results showed that the murine colon carcinoma (CT-26) tumors were completely resorbed wi...
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| Veröffentlicht in: | Anti-cancer drugs 2011-11, Vol.22 (10), p.971-977 |
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| container_title | Anti-cancer drugs |
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| creator | Hong, Chanseok Lee, Jungkeun Son, Mikwon Hong, Soon Sun Lee, Chongmu |
| description | In-vivo animal tests were performed to investigate the feasibility of photothermal therapy based on porous silicon nanoparticles (PSiNPs) in combination with a near-infrared (NIR) laser. The in-vivo animal test results showed that the murine colon carcinoma (CT-26) tumors were completely resorbed with minimal damage to surrounding healthy tissue within 5 days after PSiNPs and NIR laser treatments. In contrast, tumors in the groups treated only with PSiNPs or NIR and a control group continued to grow until the mice died. All of the mice treated with both PSiNPs and NIR remained healthy and free of tumors even 90 days after the treatment. In-vivo fluorescence imaging and the urine and feces tests revealed that PSiNPs injected intratumorally into mice were cleared mainly through the urine. The in-vivo animal test results suggest that thermotherapy based on porous silicon in combination with NIR laser irradiation can efficiently destroy cancer cells selectively without damaging the surrounding healthy cells. |
| doi_str_mv | 10.1097/CAD.0b013e32834b859c |
| format | Article |
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The in-vivo animal test results showed that the murine colon carcinoma (CT-26) tumors were completely resorbed with minimal damage to surrounding healthy tissue within 5 days after PSiNPs and NIR laser treatments. In contrast, tumors in the groups treated only with PSiNPs or NIR and a control group continued to grow until the mice died. All of the mice treated with both PSiNPs and NIR remained healthy and free of tumors even 90 days after the treatment. In-vivo fluorescence imaging and the urine and feces tests revealed that PSiNPs injected intratumorally into mice were cleared mainly through the urine. The in-vivo animal test results suggest that thermotherapy based on porous silicon in combination with NIR laser irradiation can efficiently destroy cancer cells selectively without damaging the surrounding healthy cells.</description><identifier>ISSN: 0959-4973</identifier><identifier>EISSN: 1473-5741</identifier><identifier>DOI: 10.1097/CAD.0b013e32834b859c</identifier><identifier>PMID: 21934604</identifier><language>eng</language><publisher>England: Lippincott Williams & Wilkins, Inc</publisher><subject>Animals ; Cell Line, Tumor ; Colonic Neoplasms - pathology ; Colonic Neoplasms - therapy ; Fluorescence ; Hyperthermia, Induced - methods ; Injections, Intralesional ; Laser Therapy - methods ; Male ; Mice ; Mice, Inbred BALB C ; Nanoparticles - administration & dosage ; Nanoparticles - therapeutic use ; Neoplasms, Experimental - pathology ; Neoplasms, Experimental - therapy ; Particle Size ; Polyethylene Glycols - chemistry ; Porosity ; Silicon - administration & dosage ; Silicon - pharmacology ; Solutions - chemistry ; Xenograft Model Antitumor Assays</subject><ispartof>Anti-cancer drugs, 2011-11, Vol.22 (10), p.971-977</ispartof><rights>2011 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387c-90cffecb0fae49a10739f1f091082030218dab25967ea9630fe6e0be29209e543</citedby><cites>FETCH-LOGICAL-c387c-90cffecb0fae49a10739f1f091082030218dab25967ea9630fe6e0be29209e543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21934604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hong, Chanseok</creatorcontrib><creatorcontrib>Lee, Jungkeun</creatorcontrib><creatorcontrib>Son, Mikwon</creatorcontrib><creatorcontrib>Hong, Soon Sun</creatorcontrib><creatorcontrib>Lee, Chongmu</creatorcontrib><title>In-vivo cancer cell destruction using porous silicon nanoparticles</title><title>Anti-cancer drugs</title><addtitle>Anticancer Drugs</addtitle><description>In-vivo animal tests were performed to investigate the feasibility of photothermal therapy based on porous silicon nanoparticles (PSiNPs) in combination with a near-infrared (NIR) laser. The in-vivo animal test results showed that the murine colon carcinoma (CT-26) tumors were completely resorbed with minimal damage to surrounding healthy tissue within 5 days after PSiNPs and NIR laser treatments. In contrast, tumors in the groups treated only with PSiNPs or NIR and a control group continued to grow until the mice died. All of the mice treated with both PSiNPs and NIR remained healthy and free of tumors even 90 days after the treatment. In-vivo fluorescence imaging and the urine and feces tests revealed that PSiNPs injected intratumorally into mice were cleared mainly through the urine. The in-vivo animal test results suggest that thermotherapy based on porous silicon in combination with NIR laser irradiation can efficiently destroy cancer cells selectively without damaging the surrounding healthy cells.</description><subject>Animals</subject><subject>Cell Line, Tumor</subject><subject>Colonic Neoplasms - pathology</subject><subject>Colonic Neoplasms - therapy</subject><subject>Fluorescence</subject><subject>Hyperthermia, Induced - methods</subject><subject>Injections, Intralesional</subject><subject>Laser Therapy - methods</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Nanoparticles - administration & dosage</subject><subject>Nanoparticles - therapeutic use</subject><subject>Neoplasms, Experimental - pathology</subject><subject>Neoplasms, Experimental - therapy</subject><subject>Particle Size</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Porosity</subject><subject>Silicon - administration & dosage</subject><subject>Silicon - pharmacology</subject><subject>Solutions - chemistry</subject><subject>Xenograft Model Antitumor Assays</subject><issn>0959-4973</issn><issn>1473-5741</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPw0AQhE8IRELgHyDkjsph72H7tgzhFSkSDdTW-bImBscX7uxE_HscBSgooFpp9M3saBg75zDmgNnVdHIzhgK4JCm0VIVO0B6wIVeZjJNM8UM2BEwwVpjJATsJ4RUAel0es4HgKFUKasiuZ028qTYusqax5CNLdR0tKLS-s23lmqgLVfMSrZ13XYhCVVe2FxvTuLXxbWVrCqfsqDR1oLOvO2LPd7dP04d4_ng_m07msZU6szGCLUuyBZSGFBoOmcSSl4ActAAJguuFKUSCaUYGUwklpQQFCRSAlCg5Ypf73LV3711fMV9VYdfXNNSXyxEyrnUK6b-kxjQRiUDdk2pPWu9C8FTma1-tjP_IOeS7mfN-5vz3zL3t4utBV6xo8WP63rUH9B7YurolH97qbks-X5Kp2-Xf2Z_91Yst</recordid><startdate>201111</startdate><enddate>201111</enddate><creator>Hong, Chanseok</creator><creator>Lee, Jungkeun</creator><creator>Son, Mikwon</creator><creator>Hong, Soon Sun</creator><creator>Lee, Chongmu</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TO</scope><scope>H94</scope></search><sort><creationdate>201111</creationdate><title>In-vivo cancer cell destruction using porous silicon nanoparticles</title><author>Hong, Chanseok ; Lee, Jungkeun ; Son, Mikwon ; Hong, Soon Sun ; Lee, Chongmu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387c-90cffecb0fae49a10739f1f091082030218dab25967ea9630fe6e0be29209e543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Cell Line, Tumor</topic><topic>Colonic Neoplasms - pathology</topic><topic>Colonic Neoplasms - therapy</topic><topic>Fluorescence</topic><topic>Hyperthermia, Induced - methods</topic><topic>Injections, Intralesional</topic><topic>Laser Therapy - methods</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Nanoparticles - administration & dosage</topic><topic>Nanoparticles - therapeutic use</topic><topic>Neoplasms, Experimental - pathology</topic><topic>Neoplasms, Experimental - therapy</topic><topic>Particle Size</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Porosity</topic><topic>Silicon - administration & dosage</topic><topic>Silicon - pharmacology</topic><topic>Solutions - chemistry</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hong, Chanseok</creatorcontrib><creatorcontrib>Lee, Jungkeun</creatorcontrib><creatorcontrib>Son, Mikwon</creatorcontrib><creatorcontrib>Hong, Soon Sun</creatorcontrib><creatorcontrib>Lee, Chongmu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Anti-cancer drugs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hong, Chanseok</au><au>Lee, Jungkeun</au><au>Son, Mikwon</au><au>Hong, Soon Sun</au><au>Lee, Chongmu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In-vivo cancer cell destruction using porous silicon nanoparticles</atitle><jtitle>Anti-cancer drugs</jtitle><addtitle>Anticancer Drugs</addtitle><date>2011-11</date><risdate>2011</risdate><volume>22</volume><issue>10</issue><spage>971</spage><epage>977</epage><pages>971-977</pages><issn>0959-4973</issn><eissn>1473-5741</eissn><abstract>In-vivo animal tests were performed to investigate the feasibility of photothermal therapy based on porous silicon nanoparticles (PSiNPs) in combination with a near-infrared (NIR) laser. The in-vivo animal test results showed that the murine colon carcinoma (CT-26) tumors were completely resorbed with minimal damage to surrounding healthy tissue within 5 days after PSiNPs and NIR laser treatments. In contrast, tumors in the groups treated only with PSiNPs or NIR and a control group continued to grow until the mice died. All of the mice treated with both PSiNPs and NIR remained healthy and free of tumors even 90 days after the treatment. In-vivo fluorescence imaging and the urine and feces tests revealed that PSiNPs injected intratumorally into mice were cleared mainly through the urine. The in-vivo animal test results suggest that thermotherapy based on porous silicon in combination with NIR laser irradiation can efficiently destroy cancer cells selectively without damaging the surrounding healthy cells.</abstract><cop>England</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>21934604</pmid><doi>10.1097/CAD.0b013e32834b859c</doi><tpages>7</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Cell Line, Tumor Colonic Neoplasms - pathology Colonic Neoplasms - therapy Fluorescence Hyperthermia, Induced - methods Injections, Intralesional Laser Therapy - methods Male Mice Mice, Inbred BALB C Nanoparticles - administration & dosage Nanoparticles - therapeutic use Neoplasms, Experimental - pathology Neoplasms, Experimental - therapy Particle Size Polyethylene Glycols - chemistry Porosity Silicon - administration & dosage Silicon - pharmacology Solutions - chemistry Xenograft Model Antitumor Assays |
| title | In-vivo cancer cell destruction using porous silicon nanoparticles |
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