Application of enhanced stromal vascular fraction and fat grafting mixed with PRP in post-traumatic lower extremity ulcers
The authors presented their experience in regenerative surgery of post-traumatic lower extremity ulcers, evaluating the effects related to the use of Enhanced Stromal Vascular Fraction (e-SVF) and Fat Grafting with Platelet rich Plasma (PRP). The authors compared the results of two control groups. T...
Gespeichert in:
| Veröffentlicht in: | Stem cell research 2011-03, Vol.6 (2), p.103-111 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 111 |
|---|---|
| container_issue | 2 |
| container_start_page | 103 |
| container_title | Stem cell research |
| container_volume | 6 |
| creator | Cervelli, Valerio Gentile, Pietro De Angelis, Barbara Calabrese, Claudio Di Stefani, Alessandro Scioli, Maria Giovanna Curcio, Beniamino Cristiano Felici, Marco Orlandi, Augusto |
| description | The authors presented their experience in regenerative surgery of post-traumatic lower extremity ulcers, evaluating the effects related to the use of Enhanced Stromal Vascular Fraction (e-SVF) and Fat Grafting with Platelet rich Plasma (PRP). The authors compared the results of two control groups.
The analysis involved 20 patients aged between 23 to 62
years affected by post-traumatic lower extremity ulcers. 10 patients managed with e-SVF and 10 patients managed with Fat grafting
+
PRP in the Plastic and Reconstructive Surgery Department at “Tor Vergata” University Rome. Patients in the first control group (n
=
10), were treated only with curettage and application of hyaluronic acid in the bed of ulcers. Patients in the second control group (n
=
10), were treated only with PRP.
The authors showed that wounds treated with e-SVF healed better than those treated with hyaluronic acid. In fact, after 9.7
weeks, patients treated with e-SVF underwent 97.9%
±
1.5% reepithelialisation compared to 87.8%
±
4.4% of the first control group (only hyaluronic acid; p
<
0.05). Patients treated with PRP and fat grafting also showed an improvement in reepithelialisation; in fact after 9.7
weeks, they underwent a 97.8%
±
1.5% reepithelialisation compared to 89.1%
±
3.8% of the second control group (only PRP; p
<
0.05). As reported e-SVF and PRP mixed with fat grafting were the two treatments evidencing improvement in the healing of patients post-traumatic extremity ulcers.
The results obtained proved the efficacy of these treatments, and the satisfaction of the patients confirmed the quality of the results. |
| doi_str_mv | 10.1016/j.scr.2010.11.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_907188495</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1873506110001406</els_id><sourcerecordid>851933681</sourcerecordid><originalsourceid>FETCH-LOGICAL-c427t-a16694a31691e6d1b5da21a4b3a36db78c27e1cfe5cc06ff595fdcf2629e4ee03</originalsourceid><addsrcrecordid>eNqFkU1vFSEYRonR2A_9AW4MO1dz5YWBGeKqadSaNLExuiZc5qXlZmYYgemHv15ub3WpKyA5z1lwCHkDbAMM1PvdJru04Wz_hg1j4hk5hr5TTddJ8fzxLhrJFByRk5x3jEnNe_6SHHEALVXfHZNfZ8syBmdLiDONnuJ8Y2eHA80lxcmO9NZmt442UZ-se6TsPFBvC71O1pcwX9Mp3NfBXSg39OrbFQ0zXWIuTUl2narY0THeYaJ4XxJOoTzQdXSY8ivywtsx4-un85T8-PTx-_lFc_n185fzs8vGtbwrjQWldGsFKA2oBtjKwXKw7VZYoYZt1zveITiP0jmmvJda-sF5rrjGFpGJU_Lu4F1S_LliLmYK2eE42hnjmo1mHfR9q-V_yV6CFkL1UEk4kC7FnBN6s6Qw2fRggJl9G7MztY3ZtzEAprapm7dP9nU74fB38SdGBT4cAKy_cRswVUXAfY2Q0BUzxPAP_W_fWKHE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>851933681</pqid></control><display><type>article</type><title>Application of enhanced stromal vascular fraction and fat grafting mixed with PRP in post-traumatic lower extremity ulcers</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Cervelli, Valerio ; Gentile, Pietro ; De Angelis, Barbara ; Calabrese, Claudio ; Di Stefani, Alessandro ; Scioli, Maria Giovanna ; Curcio, Beniamino Cristiano ; Felici, Marco ; Orlandi, Augusto</creator><creatorcontrib>Cervelli, Valerio ; Gentile, Pietro ; De Angelis, Barbara ; Calabrese, Claudio ; Di Stefani, Alessandro ; Scioli, Maria Giovanna ; Curcio, Beniamino Cristiano ; Felici, Marco ; Orlandi, Augusto</creatorcontrib><description>The authors presented their experience in regenerative surgery of post-traumatic lower extremity ulcers, evaluating the effects related to the use of Enhanced Stromal Vascular Fraction (e-SVF) and Fat Grafting with Platelet rich Plasma (PRP). The authors compared the results of two control groups.
The analysis involved 20 patients aged between 23 to 62
years affected by post-traumatic lower extremity ulcers. 10 patients managed with e-SVF and 10 patients managed with Fat grafting
+
PRP in the Plastic and Reconstructive Surgery Department at “Tor Vergata” University Rome. Patients in the first control group (n
=
10), were treated only with curettage and application of hyaluronic acid in the bed of ulcers. Patients in the second control group (n
=
10), were treated only with PRP.
The authors showed that wounds treated with e-SVF healed better than those treated with hyaluronic acid. In fact, after 9.7
weeks, patients treated with e-SVF underwent 97.9%
±
1.5% reepithelialisation compared to 87.8%
±
4.4% of the first control group (only hyaluronic acid; p
<
0.05). Patients treated with PRP and fat grafting also showed an improvement in reepithelialisation; in fact after 9.7
weeks, they underwent a 97.8%
±
1.5% reepithelialisation compared to 89.1%
±
3.8% of the second control group (only PRP; p
<
0.05). As reported e-SVF and PRP mixed with fat grafting were the two treatments evidencing improvement in the healing of patients post-traumatic extremity ulcers.
The results obtained proved the efficacy of these treatments, and the satisfaction of the patients confirmed the quality of the results.</description><identifier>ISSN: 1873-5061</identifier><identifier>EISSN: 1876-7753</identifier><identifier>DOI: 10.1016/j.scr.2010.11.003</identifier><identifier>PMID: 21195687</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Adipose Tissue - cytology ; Adult ; Female ; Humans ; Leg - pathology ; Leg - surgery ; Leg Ulcer - pathology ; Leg Ulcer - surgery ; Male ; Middle Aged ; Platelet-Rich Plasma ; Reconstructive Surgical Procedures - methods ; Regeneration ; Stromal Cells - transplantation ; Wound Healing ; Wounds and Injuries ; Young Adult</subject><ispartof>Stem cell research, 2011-03, Vol.6 (2), p.103-111</ispartof><rights>2010 Elsevier B.V.</rights><rights>Copyright © 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-a16694a31691e6d1b5da21a4b3a36db78c27e1cfe5cc06ff595fdcf2629e4ee03</citedby><cites>FETCH-LOGICAL-c427t-a16694a31691e6d1b5da21a4b3a36db78c27e1cfe5cc06ff595fdcf2629e4ee03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.scr.2010.11.003$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21195687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cervelli, Valerio</creatorcontrib><creatorcontrib>Gentile, Pietro</creatorcontrib><creatorcontrib>De Angelis, Barbara</creatorcontrib><creatorcontrib>Calabrese, Claudio</creatorcontrib><creatorcontrib>Di Stefani, Alessandro</creatorcontrib><creatorcontrib>Scioli, Maria Giovanna</creatorcontrib><creatorcontrib>Curcio, Beniamino Cristiano</creatorcontrib><creatorcontrib>Felici, Marco</creatorcontrib><creatorcontrib>Orlandi, Augusto</creatorcontrib><title>Application of enhanced stromal vascular fraction and fat grafting mixed with PRP in post-traumatic lower extremity ulcers</title><title>Stem cell research</title><addtitle>Stem Cell Res</addtitle><description>The authors presented their experience in regenerative surgery of post-traumatic lower extremity ulcers, evaluating the effects related to the use of Enhanced Stromal Vascular Fraction (e-SVF) and Fat Grafting with Platelet rich Plasma (PRP). The authors compared the results of two control groups.
The analysis involved 20 patients aged between 23 to 62
years affected by post-traumatic lower extremity ulcers. 10 patients managed with e-SVF and 10 patients managed with Fat grafting
+
PRP in the Plastic and Reconstructive Surgery Department at “Tor Vergata” University Rome. Patients in the first control group (n
=
10), were treated only with curettage and application of hyaluronic acid in the bed of ulcers. Patients in the second control group (n
=
10), were treated only with PRP.
The authors showed that wounds treated with e-SVF healed better than those treated with hyaluronic acid. In fact, after 9.7
weeks, patients treated with e-SVF underwent 97.9%
±
1.5% reepithelialisation compared to 87.8%
±
4.4% of the first control group (only hyaluronic acid; p
<
0.05). Patients treated with PRP and fat grafting also showed an improvement in reepithelialisation; in fact after 9.7
weeks, they underwent a 97.8%
±
1.5% reepithelialisation compared to 89.1%
±
3.8% of the second control group (only PRP; p
<
0.05). As reported e-SVF and PRP mixed with fat grafting were the two treatments evidencing improvement in the healing of patients post-traumatic extremity ulcers.
The results obtained proved the efficacy of these treatments, and the satisfaction of the patients confirmed the quality of the results.</description><subject>Adipose Tissue - cytology</subject><subject>Adult</subject><subject>Female</subject><subject>Humans</subject><subject>Leg - pathology</subject><subject>Leg - surgery</subject><subject>Leg Ulcer - pathology</subject><subject>Leg Ulcer - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Platelet-Rich Plasma</subject><subject>Reconstructive Surgical Procedures - methods</subject><subject>Regeneration</subject><subject>Stromal Cells - transplantation</subject><subject>Wound Healing</subject><subject>Wounds and Injuries</subject><subject>Young Adult</subject><issn>1873-5061</issn><issn>1876-7753</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vFSEYRonR2A_9AW4MO1dz5YWBGeKqadSaNLExuiZc5qXlZmYYgemHv15ub3WpKyA5z1lwCHkDbAMM1PvdJru04Wz_hg1j4hk5hr5TTddJ8fzxLhrJFByRk5x3jEnNe_6SHHEALVXfHZNfZ8syBmdLiDONnuJ8Y2eHA80lxcmO9NZmt442UZ-se6TsPFBvC71O1pcwX9Mp3NfBXSg39OrbFQ0zXWIuTUl2narY0THeYaJ4XxJOoTzQdXSY8ivywtsx4-un85T8-PTx-_lFc_n185fzs8vGtbwrjQWldGsFKA2oBtjKwXKw7VZYoYZt1zveITiP0jmmvJda-sF5rrjGFpGJU_Lu4F1S_LliLmYK2eE42hnjmo1mHfR9q-V_yV6CFkL1UEk4kC7FnBN6s6Qw2fRggJl9G7MztY3ZtzEAprapm7dP9nU74fB38SdGBT4cAKy_cRswVUXAfY2Q0BUzxPAP_W_fWKHE</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Cervelli, Valerio</creator><creator>Gentile, Pietro</creator><creator>De Angelis, Barbara</creator><creator>Calabrese, Claudio</creator><creator>Di Stefani, Alessandro</creator><creator>Scioli, Maria Giovanna</creator><creator>Curcio, Beniamino Cristiano</creator><creator>Felici, Marco</creator><creator>Orlandi, Augusto</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20110301</creationdate><title>Application of enhanced stromal vascular fraction and fat grafting mixed with PRP in post-traumatic lower extremity ulcers</title><author>Cervelli, Valerio ; Gentile, Pietro ; De Angelis, Barbara ; Calabrese, Claudio ; Di Stefani, Alessandro ; Scioli, Maria Giovanna ; Curcio, Beniamino Cristiano ; Felici, Marco ; Orlandi, Augusto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-a16694a31691e6d1b5da21a4b3a36db78c27e1cfe5cc06ff595fdcf2629e4ee03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adipose Tissue - cytology</topic><topic>Adult</topic><topic>Female</topic><topic>Humans</topic><topic>Leg - pathology</topic><topic>Leg - surgery</topic><topic>Leg Ulcer - pathology</topic><topic>Leg Ulcer - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Platelet-Rich Plasma</topic><topic>Reconstructive Surgical Procedures - methods</topic><topic>Regeneration</topic><topic>Stromal Cells - transplantation</topic><topic>Wound Healing</topic><topic>Wounds and Injuries</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cervelli, Valerio</creatorcontrib><creatorcontrib>Gentile, Pietro</creatorcontrib><creatorcontrib>De Angelis, Barbara</creatorcontrib><creatorcontrib>Calabrese, Claudio</creatorcontrib><creatorcontrib>Di Stefani, Alessandro</creatorcontrib><creatorcontrib>Scioli, Maria Giovanna</creatorcontrib><creatorcontrib>Curcio, Beniamino Cristiano</creatorcontrib><creatorcontrib>Felici, Marco</creatorcontrib><creatorcontrib>Orlandi, Augusto</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Stem cell research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cervelli, Valerio</au><au>Gentile, Pietro</au><au>De Angelis, Barbara</au><au>Calabrese, Claudio</au><au>Di Stefani, Alessandro</au><au>Scioli, Maria Giovanna</au><au>Curcio, Beniamino Cristiano</au><au>Felici, Marco</au><au>Orlandi, Augusto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Application of enhanced stromal vascular fraction and fat grafting mixed with PRP in post-traumatic lower extremity ulcers</atitle><jtitle>Stem cell research</jtitle><addtitle>Stem Cell Res</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>6</volume><issue>2</issue><spage>103</spage><epage>111</epage><pages>103-111</pages><issn>1873-5061</issn><eissn>1876-7753</eissn><abstract>The authors presented their experience in regenerative surgery of post-traumatic lower extremity ulcers, evaluating the effects related to the use of Enhanced Stromal Vascular Fraction (e-SVF) and Fat Grafting with Platelet rich Plasma (PRP). The authors compared the results of two control groups.
The analysis involved 20 patients aged between 23 to 62
years affected by post-traumatic lower extremity ulcers. 10 patients managed with e-SVF and 10 patients managed with Fat grafting
+
PRP in the Plastic and Reconstructive Surgery Department at “Tor Vergata” University Rome. Patients in the first control group (n
=
10), were treated only with curettage and application of hyaluronic acid in the bed of ulcers. Patients in the second control group (n
=
10), were treated only with PRP.
The authors showed that wounds treated with e-SVF healed better than those treated with hyaluronic acid. In fact, after 9.7
weeks, patients treated with e-SVF underwent 97.9%
±
1.5% reepithelialisation compared to 87.8%
±
4.4% of the first control group (only hyaluronic acid; p
<
0.05). Patients treated with PRP and fat grafting also showed an improvement in reepithelialisation; in fact after 9.7
weeks, they underwent a 97.8%
±
1.5% reepithelialisation compared to 89.1%
±
3.8% of the second control group (only PRP; p
<
0.05). As reported e-SVF and PRP mixed with fat grafting were the two treatments evidencing improvement in the healing of patients post-traumatic extremity ulcers.
The results obtained proved the efficacy of these treatments, and the satisfaction of the patients confirmed the quality of the results.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>21195687</pmid><doi>10.1016/j.scr.2010.11.003</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1873-5061 |
| ispartof | Stem cell research, 2011-03, Vol.6 (2), p.103-111 |
| issn | 1873-5061 1876-7753 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_907188495 |
| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Adipose Tissue - cytology Adult Female Humans Leg - pathology Leg - surgery Leg Ulcer - pathology Leg Ulcer - surgery Male Middle Aged Platelet-Rich Plasma Reconstructive Surgical Procedures - methods Regeneration Stromal Cells - transplantation Wound Healing Wounds and Injuries Young Adult |
| title | Application of enhanced stromal vascular fraction and fat grafting mixed with PRP in post-traumatic lower extremity ulcers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T16%3A09%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Application%20of%20enhanced%20stromal%20vascular%20fraction%20and%20fat%20grafting%20mixed%20with%20PRP%20in%20post-traumatic%20lower%20extremity%20ulcers&rft.jtitle=Stem%20cell%20research&rft.au=Cervelli,%20Valerio&rft.date=2011-03-01&rft.volume=6&rft.issue=2&rft.spage=103&rft.epage=111&rft.pages=103-111&rft.issn=1873-5061&rft.eissn=1876-7753&rft_id=info:doi/10.1016/j.scr.2010.11.003&rft_dat=%3Cproquest_cross%3E851933681%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=851933681&rft_id=info:pmid/21195687&rft_els_id=S1873506110001406&rfr_iscdi=true |