Hydroxyalkylated phosphoramidate, phosphoramidothioate and phosphorodiamidothioate derivatives as thiophosphate protecting groups in the development of thermolytic DNA prodrugs

The hydroxyalkylated phosphoramidate 4a, phosphoramidothioates 4b, 4e-j, and phosphorodiamidothioates 4c and 4d have been identified as a new class of heat-sensitive thiophosphate protecting groups in the development of thermolytic immunomodulatory DNA prodrugs. These alcohols are converted to their...

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Veröffentlicht in:	New journal of chemistry 2010, Vol.34 (5), p.880-887
Hauptverfasser:	Grajkowski, Andrzej, Cieślak, Jacek, Gapeev, Alexei, Beaucage, Serge L.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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