Cysteine 149 in the extracellular finger domain of acid-sensing ion channel 1b subunit is critical for zinc-mediated inhibition

Abstract Acid-sensing ion channel 1b (ASIC1b) is a proton-gated Na+ channel mostly expressed in peripheral sensory neurons. To date, the functional significance of ASIC1b in these cells is unclear due to the lack of a specific inhibitor/blocker. A better understanding of the regulation of ASIC1b may...

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Veröffentlicht in:	Neuroscience 2011-10, Vol.193, p.89-99
Hauptverfasser:	Jiang, Q, Inoue, K, Wu, X, Papasian, C.J, Wang, J.Q, Xiong, Z.G, Chu, X.P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Sensing Ion Channels Analysis of Variance Animals ASIC1b Biological and medical sciences Calcium - pharmacology Cell Line, Transformed Cricetinae Cricetulus Cysteine - genetics Cysteine - metabolism Dose-Response Relationship, Drug Ethyl Methanesulfonate - analogs & derivatives Ethyl Methanesulfonate - pharmacology Extracellular Fluid - metabolism Fundamental and applied biological sciences. Psychology Hydrogen Peroxide Membrane Potentials - drug effects Membrane Potentials - genetics Mutagenesis, Site-Directed - methods Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurology patch-clamp Patch-Clamp Techniques Protein Structure, Tertiary - genetics Rats Sodium Channels - genetics Sodium Channels - metabolism Trace Elements - pharmacology Transfection Vertebrates: nervous system and sense organs zinc Zinc - pharmacology
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