Mixed infection with Beijing and non-Beijing strains in pulmonary tuberculosis in Taiwan: prevalence, risk factors, and dominant strain
Patients with pulmonary tuberculosis (TB) can be simultaneously infected with different strains of Mycobacterium tuberculosis (mixed infection). We investigated the prevalence and risk factors of mixed infection by Beijing and non-Beijing strains in pulmonary TB patients in Taiwan. We developed a qu...
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| Veröffentlicht in: | Clinical microbiology and infection 2011-08, Vol.17 (8), p.1239-1245 |
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| description | Patients with pulmonary tuberculosis (TB) can be simultaneously infected with different strains of Mycobacterium tuberculosis (mixed infection). We investigated the prevalence and risk factors of mixed infection by Beijing and non-Beijing strains in pulmonary TB patients in Taiwan. We developed a quantitative PCR method to simultaneously detect the presence of Beijing and non-Beijing strains. A total of 868 pre-treatment samples (from 868 patients), including 563 sputum samples smear-positive for acid-fast bacilli and 305 liquid medium samples culture-positive for mycobacteria, were tested. Medical records of patients with culture-confirmed pulmonary TB were reviewed. The detection limit of our quantitative PCR method was five copies of target sequences. With mycobacterial culture result as the reference standard, the sensitivity and specificity of our quantitative PCR method were 95% and 98%, respectively. M. tuberculosis strains were isolated in 466 samples, of which 231 (49.6%) were infected with a Beijing strain. Another 14 patients (3.0%) had mixed infection, with the Beijing strain being the dominant strain in 13 (93%). Age |
| doi_str_mv | 10.1111/j.1469-0691.2010.03401.x |
| format | Article |
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We investigated the prevalence and risk factors of mixed infection by Beijing and non-Beijing strains in pulmonary TB patients in Taiwan. We developed a quantitative PCR method to simultaneously detect the presence of Beijing and non-Beijing strains. A total of 868 pre-treatment samples (from 868 patients), including 563 sputum samples smear-positive for acid-fast bacilli and 305 liquid medium samples culture-positive for mycobacteria, were tested. Medical records of patients with culture-confirmed pulmonary TB were reviewed. The detection limit of our quantitative PCR method was five copies of target sequences. With mycobacterial culture result as the reference standard, the sensitivity and specificity of our quantitative PCR method were 95% and 98%, respectively. M. tuberculosis strains were isolated in 466 samples, of which 231 (49.6%) were infected with a Beijing strain. Another 14 patients (3.0%) had mixed infection, with the Beijing strain being the dominant strain in 13 (93%). Age <25 years with pulmonary cavities was associated with mixed infection. In patients infected with non-Beijing strains, the bacterial load of non-Beijing strains was lower among those with mixed infection than among those without. Our quantitative PCR method was accurate in detecting Beijing and non-Beijing strains in smear-positive sputum and culture-positive liquid medium samples. Mixed infection was present in pulmonary TB patients (3.0%), especially in those aged <25 years with pulmonary cavities. Beijing strains seem to be more dominant than non-Beijing strains in patients with mixed infection.</description><identifier>ISSN: 1198-743X</identifier><identifier>EISSN: 1469-0691</identifier><identifier>DOI: 10.1111/j.1469-0691.2010.03401.x</identifier><identifier>PMID: 20946415</identifier><language>eng</language><publisher>Oxford, UK: Elsevier Ltd</publisher><subject>Adult ; Age ; Aged ; Bacilli ; Bacterial diseases ; Bacterial diseases of the respiratory system ; Bacterial Load ; Beijing strain ; Biological and medical sciences ; Cavities ; Culture Media ; Female ; Human bacterial diseases ; Humans ; Infectious diseases ; Lung ; Male ; medical records ; Medical sciences ; Middle Aged ; Mixed infection ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - classification ; Mycobacterium tuberculosis - genetics ; Mycobacterium tuberculosis - isolation & purification ; Polymerase chain reaction ; Polymerase Chain Reaction - methods ; Prevalence ; quantitative PCR ; Risk Factors ; Species Specificity ; Sputum ; Sputum - microbiology ; Taiwan ; Taiwan - epidemiology ; Tuberculosis ; Tuberculosis and atypical mycobacterial infections ; Tuberculosis, Pulmonary - epidemiology ; Tuberculosis, Pulmonary - microbiology ; Young Adult</subject><ispartof>Clinical microbiology and infection, 2011-08, Vol.17 (8), p.1239-1245</ispartof><rights>2011 European Society of Clinical Infectious Diseases</rights><rights>2010 The Authors. Clinical Microbiology and Infection © 2010 European Society of Clinical Microbiology and Infectious Diseases</rights><rights>2015 INIST-CNRS</rights><rights>2010 The Authors. Clinical Microbiology and Infection © 2010 European Society of Clinical Microbiology and Infectious Diseases.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5671-644dee82763e28a79c40cb1447f96287b74f00b7b6d36fad9ca8a85d41cbbb923</citedby><cites>FETCH-LOGICAL-c5671-644dee82763e28a79c40cb1447f96287b74f00b7b6d36fad9ca8a85d41cbbb923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1469-0691.2010.03401.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1469-0691.2010.03401.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24350760$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20946415$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, J.-Y.</creatorcontrib><creatorcontrib>Hsu, H.-L.</creatorcontrib><creatorcontrib>Yu, M.-C.</creatorcontrib><creatorcontrib>Chiang, C.-Y.</creatorcontrib><creatorcontrib>Yu, F.-L.</creatorcontrib><creatorcontrib>Yu, C.-J.</creatorcontrib><creatorcontrib>Lee, L.-N.</creatorcontrib><creatorcontrib>Yang, P.-C.</creatorcontrib><creatorcontrib>the TAMI Group</creatorcontrib><creatorcontrib>TAMI Group</creatorcontrib><title>Mixed infection with Beijing and non-Beijing strains in pulmonary tuberculosis in Taiwan: prevalence, risk factors, and dominant strain</title><title>Clinical microbiology and infection</title><addtitle>Clin Microbiol Infect</addtitle><description>Patients with pulmonary tuberculosis (TB) can be simultaneously infected with different strains of Mycobacterium tuberculosis (mixed infection). We investigated the prevalence and risk factors of mixed infection by Beijing and non-Beijing strains in pulmonary TB patients in Taiwan. We developed a quantitative PCR method to simultaneously detect the presence of Beijing and non-Beijing strains. A total of 868 pre-treatment samples (from 868 patients), including 563 sputum samples smear-positive for acid-fast bacilli and 305 liquid medium samples culture-positive for mycobacteria, were tested. Medical records of patients with culture-confirmed pulmonary TB were reviewed. The detection limit of our quantitative PCR method was five copies of target sequences. With mycobacterial culture result as the reference standard, the sensitivity and specificity of our quantitative PCR method were 95% and 98%, respectively. M. tuberculosis strains were isolated in 466 samples, of which 231 (49.6%) were infected with a Beijing strain. Another 14 patients (3.0%) had mixed infection, with the Beijing strain being the dominant strain in 13 (93%). Age <25 years with pulmonary cavities was associated with mixed infection. In patients infected with non-Beijing strains, the bacterial load of non-Beijing strains was lower among those with mixed infection than among those without. Our quantitative PCR method was accurate in detecting Beijing and non-Beijing strains in smear-positive sputum and culture-positive liquid medium samples. Mixed infection was present in pulmonary TB patients (3.0%), especially in those aged <25 years with pulmonary cavities. Beijing strains seem to be more dominant than non-Beijing strains in patients with mixed infection.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Bacilli</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the respiratory system</subject><subject>Bacterial Load</subject><subject>Beijing strain</subject><subject>Biological and medical sciences</subject><subject>Cavities</subject><subject>Culture Media</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Lung</subject><subject>Male</subject><subject>medical records</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mixed infection</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - classification</subject><subject>Mycobacterium tuberculosis - genetics</subject><subject>Mycobacterium tuberculosis - isolation & purification</subject><subject>Polymerase chain reaction</subject><subject>Polymerase Chain Reaction - methods</subject><subject>Prevalence</subject><subject>quantitative PCR</subject><subject>Risk Factors</subject><subject>Species Specificity</subject><subject>Sputum</subject><subject>Sputum - microbiology</subject><subject>Taiwan</subject><subject>Taiwan - epidemiology</subject><subject>Tuberculosis</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Tuberculosis, Pulmonary - epidemiology</subject><subject>Tuberculosis, Pulmonary - microbiology</subject><subject>Young Adult</subject><issn>1198-743X</issn><issn>1469-0691</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkl1vFCEUhidGY-vqXzAkxnjTWWFg-DDxwm7qR7KNNzXxjjDAKOMMrDDT3f4C_3aZ3W1NvKnccOA87-HAS1EABJcoj7fdEhEqSkgFWlYw70JMIFruHhWn94nHOUaCl4zg7yfFs5Q6CGGFMXlanFRQEEpQfVr8uXQ7a4DzrdWjCx5s3fgTnFvXOf8DKG-AD768W6cxKudTxsFm6ofgVbwB49TYqKc-JLfPXCm3Vf4d2ER7rXrrtT0D0aVfoFV6DDGd7cuaMDiv_His-bx40qo-2RfHeVF8-3hxtfpcrr9--rL6sC51TRkqKSHGWl4xim3FFROaQN0gQlgraMVZw0gLYcMaajBtlRFaccVrQ5BumkZUeFG8OdTdxPB7smmUg0va9r3yNkxJCsgQR6QiD5Kcc4wpxHPNV_-QXZiiz9eQqCa1wBkUmeIHSseQUrSt3EQ35AeUCMrZVdnJ2Tw5mydnV-XeVbnL0pfHA6ZmsOZeeGdjBl4fAZW06tuovHbpL0dwDVnudVG8P3Bb19ub_25ArtaXc5T15we9zRZdOxtl0m522LiY_480wT18m1vJX9NG</recordid><startdate>201108</startdate><enddate>201108</enddate><creator>Wang, J.-Y.</creator><creator>Hsu, H.-L.</creator><creator>Yu, M.-C.</creator><creator>Chiang, C.-Y.</creator><creator>Yu, F.-L.</creator><creator>Yu, C.-J.</creator><creator>Lee, L.-N.</creator><creator>Yang, P.-C.</creator><general>Elsevier Ltd</general><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201108</creationdate><title>Mixed infection with Beijing and non-Beijing strains in pulmonary tuberculosis in Taiwan: prevalence, risk factors, and dominant strain</title><author>Wang, J.-Y. ; Hsu, H.-L. ; Yu, M.-C. ; Chiang, C.-Y. ; Yu, F.-L. ; Yu, C.-J. ; Lee, L.-N. ; Yang, P.-C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5671-644dee82763e28a79c40cb1447f96287b74f00b7b6d36fad9ca8a85d41cbbb923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Bacilli</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the respiratory system</topic><topic>Bacterial Load</topic><topic>Beijing strain</topic><topic>Biological and medical sciences</topic><topic>Cavities</topic><topic>Culture Media</topic><topic>Female</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Lung</topic><topic>Male</topic><topic>medical records</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mixed infection</topic><topic>Mycobacterium tuberculosis</topic><topic>Mycobacterium tuberculosis - classification</topic><topic>Mycobacterium tuberculosis - genetics</topic><topic>Mycobacterium tuberculosis - isolation & purification</topic><topic>Polymerase chain reaction</topic><topic>Polymerase Chain Reaction - methods</topic><topic>Prevalence</topic><topic>quantitative PCR</topic><topic>Risk Factors</topic><topic>Species Specificity</topic><topic>Sputum</topic><topic>Sputum - microbiology</topic><topic>Taiwan</topic><topic>Taiwan - epidemiology</topic><topic>Tuberculosis</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><topic>Tuberculosis, Pulmonary - epidemiology</topic><topic>Tuberculosis, Pulmonary - microbiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, J.-Y.</creatorcontrib><creatorcontrib>Hsu, H.-L.</creatorcontrib><creatorcontrib>Yu, M.-C.</creatorcontrib><creatorcontrib>Chiang, C.-Y.</creatorcontrib><creatorcontrib>Yu, F.-L.</creatorcontrib><creatorcontrib>Yu, C.-J.</creatorcontrib><creatorcontrib>Lee, L.-N.</creatorcontrib><creatorcontrib>Yang, P.-C.</creatorcontrib><creatorcontrib>the TAMI Group</creatorcontrib><creatorcontrib>TAMI Group</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical microbiology and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, J.-Y.</au><au>Hsu, H.-L.</au><au>Yu, M.-C.</au><au>Chiang, C.-Y.</au><au>Yu, F.-L.</au><au>Yu, C.-J.</au><au>Lee, L.-N.</au><au>Yang, P.-C.</au><aucorp>the TAMI Group</aucorp><aucorp>TAMI Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mixed infection with Beijing and non-Beijing strains in pulmonary tuberculosis in Taiwan: prevalence, risk factors, and dominant strain</atitle><jtitle>Clinical microbiology and infection</jtitle><addtitle>Clin Microbiol Infect</addtitle><date>2011-08</date><risdate>2011</risdate><volume>17</volume><issue>8</issue><spage>1239</spage><epage>1245</epage><pages>1239-1245</pages><issn>1198-743X</issn><eissn>1469-0691</eissn><abstract>Patients with pulmonary tuberculosis (TB) can be simultaneously infected with different strains of Mycobacterium tuberculosis (mixed infection). We investigated the prevalence and risk factors of mixed infection by Beijing and non-Beijing strains in pulmonary TB patients in Taiwan. We developed a quantitative PCR method to simultaneously detect the presence of Beijing and non-Beijing strains. A total of 868 pre-treatment samples (from 868 patients), including 563 sputum samples smear-positive for acid-fast bacilli and 305 liquid medium samples culture-positive for mycobacteria, were tested. Medical records of patients with culture-confirmed pulmonary TB were reviewed. The detection limit of our quantitative PCR method was five copies of target sequences. With mycobacterial culture result as the reference standard, the sensitivity and specificity of our quantitative PCR method were 95% and 98%, respectively. M. tuberculosis strains were isolated in 466 samples, of which 231 (49.6%) were infected with a Beijing strain. Another 14 patients (3.0%) had mixed infection, with the Beijing strain being the dominant strain in 13 (93%). Age <25 years with pulmonary cavities was associated with mixed infection. In patients infected with non-Beijing strains, the bacterial load of non-Beijing strains was lower among those with mixed infection than among those without. Our quantitative PCR method was accurate in detecting Beijing and non-Beijing strains in smear-positive sputum and culture-positive liquid medium samples. Mixed infection was present in pulmonary TB patients (3.0%), especially in those aged <25 years with pulmonary cavities. Beijing strains seem to be more dominant than non-Beijing strains in patients with mixed infection.</abstract><cop>Oxford, UK</cop><pub>Elsevier Ltd</pub><pmid>20946415</pmid><doi>10.1111/j.1469-0691.2010.03401.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Aged Bacilli Bacterial diseases Bacterial diseases of the respiratory system Bacterial Load Beijing strain Biological and medical sciences Cavities Culture Media Female Human bacterial diseases Humans Infectious diseases Lung Male medical records Medical sciences Middle Aged Mixed infection Mycobacterium tuberculosis Mycobacterium tuberculosis - classification Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - isolation & purification Polymerase chain reaction Polymerase Chain Reaction - methods Prevalence quantitative PCR Risk Factors Species Specificity Sputum Sputum - microbiology Taiwan Taiwan - epidemiology Tuberculosis Tuberculosis and atypical mycobacterial infections Tuberculosis, Pulmonary - epidemiology Tuberculosis, Pulmonary - microbiology Young Adult |
| title | Mixed infection with Beijing and non-Beijing strains in pulmonary tuberculosis in Taiwan: prevalence, risk factors, and dominant strain |
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