Computer Simulations of Peptides from the p53 DNA Binding Domain

We have studied the dynamics and thermodynamics of two of the four evolutionarily conserved segments from the p53 DNA binding domain, using molecular dynamics and replica exchange simulations. These two regions contain well-defined elements of secondary structure (a β hairpin for region II and an α...

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Veröffentlicht in:	Journal of chemical theory and computation 2009-05, Vol.5 (5), p.1380-1392
Hauptverfasser:	Khalili, Mey, Wales, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomolecular Systems
Online-Zugang:	Volltext
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