Mutated Ras Peptides as Vaccines in Immunotherapy of Cancer

Mutations in codon 12 and 13 of K‐RAS are frequently found in human cancer, including pancreatic‐ and colorectal adenocarcinomas. T cell responses specific for individual RAS mutations can be elicited in vitro by stimulation with synthetic peptides and in vivo following vaccination with antigen pres...

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Veröffentlicht in:	Vox sanguinis 1998-06, Vol.74 (S2), p.489-495
Hauptverfasser:	Gjertsen, M.K., Gaudernack, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adjuvants Adjuvants, Immunologic Antigen Presentation Antigen-presenting cells Antineoplastic agents Biological and medical sciences Cancer Cancer Vaccines - immunology Cancer Vaccines - therapeutic use CD4 antigen CD4-Positive T-Lymphocytes - immunology Clinical Trials as Topic Codon - genetics Codons Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - immunology Colorectal Neoplasms - therapy Epitopes Epitopes - immunology Forecasting Genes, ras Granulocyte-macrophage colony-stimulating factor Humans Immunotherapy K-Ras protein Lymphocyte Activation Lymphocytes T Medical sciences Mutation Neoplasms - genetics Neoplasms - immunology Neoplasms - therapy Pancreas Pancreatic Neoplasms - genetics Pancreatic Neoplasms - immunology Pancreatic Neoplasms - therapy Peptide Fragments - genetics Peptide Fragments - immunology Peptide Fragments - therapeutic use Pharmacology. Drug treatments Ras protein ras Proteins - genetics ras Proteins - immunology ras Proteins - therapeutic use synthetic peptides T-Lymphocytes, Cytotoxic - immunology Tumor cell lines Vaccines Vaccines, Synthetic - immunology Vaccines, Synthetic - therapeutic use
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