2,5-Disubstituted-1,3,4-oxadiazoles/thiadiazole as surface recognition moiety: Design and synthesis of novel hydroxamic acid based histone deacetylase inhibitors

Two novel series of 1,3,4-oxadiazole/thiadiazole analogs were synthesized to meet pharmacophoric structural requirements necessary for HDAC inhibitors, that is, zinc binding group (C), linker (B), and surface recognition cap group (A). Anticancer evaluation using histone deacetylase inhibitors assay...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2011-10, Vol.21 (19), p.5735-5738
Hauptverfasser:	Rajak, Harish, Agarawal, Avantika, Parmar, Poonam, Thakur, Bhupendra Singh, Veerasamy, Ravichandran, Sharma, Prabodh Chander, Kharya, Murli Dhar
Format:	Artikel
Sprache:	eng
Schlagworte:	1,3,4-Oxadiazoles 1,3,4-Thiadiazoles Animals Anticancer activity anticarcinogenic activity Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor activity ascites Biological and medical sciences carcinoma Carcinoma, Ehrlich Tumor - drug therapy Cell Proliferation Drug Design Drug Evaluation, Preclinical Drug Screening Assays, Antitumor enzyme inhibition General aspects histone deacetylase Histone deacetylase inhibitors Histone Deacetylase Inhibitors - chemical synthesis Histone Deacetylase Inhibitors - chemistry Histone Deacetylase Inhibitors - pharmacology Hydroxamic Acids - chemistry Medical sciences Mice Neoplasms - drug therapy Oxadiazoles - chemistry Pharmacology. Drug treatments Structure-Activity Relationship structure-activity relationships Surface Properties Thiadiazoles - chemistry Zinc - chemistry
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