Distinct Modes of AMPA Receptor Suppression at Developing Synapses by GluN2A and GluN2B: Single-Cell NMDA Receptor Subunit Deletion In Vivo

During development there is an activity-dependent switch in synaptic N-Methyl-D-aspartate (NMDA) receptor subunit composition from predominantly GluN2B to GluN2A, though the precise role of this switch remains unknown. By deleting GluN2 subunits in single neurons during synaptogenesis, we find that...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2011-09, Vol.71 (6), p.1085-1101
Hauptverfasser:	Gray, John A., Shi, Yun, Usui, Hiroshi, During, Matthew J., Sakimura, Kenji, Nicoll, Roger A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dendrites - metabolism Dendrites - ultrastructure Dizocilpine Maleate - pharmacology Excitatory Amino Acid Antagonists - pharmacology Excitatory Postsynaptic Potentials - physiology Glutamic acid receptors Hippocampus - cytology Mice Neurons Patch-Clamp Techniques Piperidines - pharmacology Protein Subunits - genetics Protein Subunits - metabolism Pyramidal Cells - cytology Pyramidal Cells - drug effects Pyramidal Cells - metabolism Quinoxalines - pharmacology Receptors, AMPA - genetics Receptors, AMPA - metabolism Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism Rodents Synapses - physiology
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