Potent Antitumor Immunity Generated by a CD40-Targeted Adenoviral Vaccine

In situ delivery of tumor-associated antigen (TAA) genes into dendritic cells (DC) has great potential as a generally applicable tumor vaccination approach. Although adenoviruses (Ad) are an attractive vaccine vehicle in this regard, Ad-mediated transduction of DCs is hampered by the lack of express...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2011-09, Vol.71 (17), p.5827-5837
Hauptverfasser:	HANGALAPURA, Basav N, OOSTERHOFF, Dinja, SCHEPER, Rik J, DE GRUIJL, Tanja D, DE GROOT, Jan, BOON, Louis, TÜTING, Thomas, VAN DEN EERTWEGH, Alfons J, GERRITSEN, Winald R, VAN BEUSECHEM, Victor W, PEREBOEV, Alexander, CURIEL, David T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Animals Antigens, Tumor-Associated, Carbohydrate - genetics Antigens, Tumor-Associated, Carbohydrate - immunology Antineoplastic agents Biological and medical sciences Cancer Vaccines - administration & dosage Cancer Vaccines - genetics Cancer Vaccines - immunology CD40 Antigens - immunology CD40 Ligand - immunology Dendritic Cells - immunology Lymph Nodes - immunology Medical sciences Melanoma, Experimental - immunology Melanoma, Experimental - prevention & control Mice Mice, Inbred C57BL Pharmacology. Drug treatments Skin Neoplasms - immunology Skin Neoplasms - prevention & control T-Lymphocytes - immunology Transduction, Genetic Tumors
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