Toll‐like receptor 3 C1234T may protect against geographic atrophy through decreased dsRNA binding capacity

ABSTRACT The genetic association between a variant in the Toll‐like receptor 3 (TLR3) gene (C1234T in mRNA, L412F in protein, Reference SNP Cluster Report rs3775291) and geographic atrophy (GA; also called advanced “dry” age‐related macular degeneration) was controversial in previous studies. We per...

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Veröffentlicht in:	The FASEB journal 2011-10, Vol.25 (10), p.3489-3495
Hauptverfasser:	Zhou, Peng, Fan, Lei, Yu, Ke‐Da, Zhao, Ming‐Wei, Li, Xiao‐Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	age‐related macular degeneration double‐stranded RNA Gene Expression Regulation - physiology Genetic Predisposition to Disease Geographic Atrophy - genetics Humans Odds Ratio Polymorphism, Single Nucleotide Risk Factors RNA, Double-Stranded - genetics RNA, Double-Stranded - metabolism Toll-Like Receptor 3 - genetics Toll-Like Receptor 3 - metabolism
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