Cell-free DNA in the Circulation as a Potential Cancer Biomarker
In the course of the search for new biomarkers, circulating cell-free DNA (ccf-DNA) has become a popular target of interest. An elevated level of ccf-DNA has been detected in the circulation of cancer patients in comparison with healthy controls. Since ccf-DNA in cancer patients often bears similar...
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| Veröffentlicht in: | Anticancer research 2011-08, Vol.31 (8), p.2623-2628 |
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| container_title | Anticancer research |
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| creator | KOHLER, Corina BAREKATI, Zeinab RADPOUR, Ramin YAN ZHONG, Xiao |
| description | In the course of the search for new biomarkers, circulating cell-free DNA (ccf-DNA) has become a popular target of interest. An elevated level of ccf-DNA has been detected in the circulation of cancer patients in comparison with healthy controls. Since ccf-DNA in cancer patients often bears similar genetic and epigenetic features to the related tumor DNA, there is evidence that some of the ccf-DNA originates from tumoral tissue. This, and the fact that ccf-DNA can easily be isolated from the circulation and other body fluids of patients, makes it a promising candidate as a non-invasive biomarker of cancer. Yet ccf-DNA-based cancer tests have not come to fruitful clinical applications. This review evaluates the potential of ccf-DNA alterations as a biomarker for cancer management by addressing the question of how large the gap between ccf-DNA and the ideal cancer biomarker is. |
| format | Article |
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An elevated level of ccf-DNA has been detected in the circulation of cancer patients in comparison with healthy controls. Since ccf-DNA in cancer patients often bears similar genetic and epigenetic features to the related tumor DNA, there is evidence that some of the ccf-DNA originates from tumoral tissue. This, and the fact that ccf-DNA can easily be isolated from the circulation and other body fluids of patients, makes it a promising candidate as a non-invasive biomarker of cancer. Yet ccf-DNA-based cancer tests have not come to fruitful clinical applications. 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This review evaluates the potential of ccf-DNA alterations as a biomarker for cancer management by addressing the question of how large the gap between ccf-DNA and the ideal cancer biomarker is.</description><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biomarkers, Tumor - genetics</subject><subject>DNA - blood</subject><subject>DNA - genetics</subject><subject>Epigenesis, Genetic</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Microsatellite Repeats - genetics</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0DtPwzAUBWALgWgp_AXkBTFF8iPxtTdKKA-pAgaYo1vnRhjSpNjJwL8nEkWMTHf5dHTOPWBzCU5mUGhxyOZCFSIDIYoZO0npXQhjnNXHbKYkgNUyn7Orkto2ayIRv3lc8tDx4Y14GaIfWxxC33FMHPlzP1A3BGx5iZ2nyK9Dv8X4QfGUHTXYJjrb3wV7vV29lPfZ-unuoVyus50CNWS5LExj9cY3fqqhrPWFsU4BgNCSrAC0zpGjwmpjwbsaanIeBXqPgJtaL9jlT-4u9p8jpaHahuSn8thRP6bKCZBgrYF_pZ2YUuDUJM_3ctxsqa52MUyjvqrf90zgYg8weWybOI0P6c_luTHS5vobUM9sgA</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>KOHLER, Corina</creator><creator>BAREKATI, Zeinab</creator><creator>RADPOUR, Ramin</creator><creator>YAN ZHONG, Xiao</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7TM</scope></search><sort><creationdate>20110801</creationdate><title>Cell-free DNA in the Circulation as a Potential Cancer Biomarker</title><author>KOHLER, Corina ; BAREKATI, Zeinab ; RADPOUR, Ramin ; YAN ZHONG, Xiao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p272t-4156f83bcfc006288c56892777031e807a899e9e583687c9d7de9ca0acca7abd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - blood</topic><topic>Biomarkers, Tumor - genetics</topic><topic>DNA - blood</topic><topic>DNA - genetics</topic><topic>Epigenesis, Genetic</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Microsatellite Repeats - genetics</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOHLER, Corina</creatorcontrib><creatorcontrib>BAREKATI, Zeinab</creatorcontrib><creatorcontrib>RADPOUR, Ramin</creatorcontrib><creatorcontrib>YAN ZHONG, Xiao</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOHLER, Corina</au><au>BAREKATI, Zeinab</au><au>RADPOUR, Ramin</au><au>YAN ZHONG, Xiao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell-free DNA in the Circulation as a Potential Cancer Biomarker</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>31</volume><issue>8</issue><spage>2623</spage><epage>2628</epage><pages>2623-2628</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>In the course of the search for new biomarkers, circulating cell-free DNA (ccf-DNA) has become a popular target of interest. 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| language | eng |
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| source | Elektronische Zeitschriftenbibliothek (Open access); MEDLINE |
| subjects | Biological and medical sciences Biomarkers, Tumor - blood Biomarkers, Tumor - genetics DNA - blood DNA - genetics Epigenesis, Genetic Humans Medical sciences Microsatellite Repeats - genetics Tumors |
| title | Cell-free DNA in the Circulation as a Potential Cancer Biomarker |
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