Immunosuppressive Treatment for Mixed Connective Tissue Disease May Facilitate the Development of Adult T Cell Leukemia/Lymphoma in a HTLVI Carrier
A 66yearold woman who was positive for human Tlymphotropic virus type I (HTLVI) antibody developed mixed connective tissue disease (MCTD) with interstitial pneumonia, and was successfully treated with corticosteroid. One year later, under maintenance treatment of prednisolone (PSL), she contracted a...
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| Veröffentlicht in: | Internal Medicine 2006, Vol.45(5), pp.297-301 |
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| creator | Fujiwara, Hiroshi Nakamura, Daisuke Kukita, Toshimasa Hamada, Heiichiro Ozaki, Atsuo Matsushita, Kakushi Matsumoto, Tadashi Tei, Chuwa |
| description | A 66yearold woman who was positive for human Tlymphotropic virus type I (HTLVI) antibody developed mixed connective tissue disease (MCTD) with interstitial pneumonia, and was successfully treated with corticosteroid. One year later, under maintenance treatment of prednisolone (PSL), she contracted acute type adult Tcell leukemia/lymphoma (ATLL) without flaring of MCTD. MCTD is considered to be as one of the HTLVIrelated inflammatory diseases, however the development of ATLL during the treatment of HTLVIrelated MCTD has not been well studied. Here, we review the literature and raise the issue of the mutual interactions between MCTDcausative antiHTLVI immune response and antiATLL immune response. |
| doi_str_mv | 10.2169/internalmedicine.45.1490 |
| format | Article |
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Med.</addtitle><description>A 66yearold woman who was positive for human Tlymphotropic virus type I (HTLVI) antibody developed mixed connective tissue disease (MCTD) with interstitial pneumonia, and was successfully treated with corticosteroid. One year later, under maintenance treatment of prednisolone (PSL), she contracted acute type adult Tcell leukemia/lymphoma (ATLL) without flaring of MCTD. MCTD is considered to be as one of the HTLVIrelated inflammatory diseases, however the development of ATLL during the treatment of HTLVIrelated MCTD has not been well studied. Here, we review the literature and raise the issue of the mutual interactions between MCTDcausative antiHTLVI immune response and antiATLL immune response.</description><subject>adult Tcell leukemia/lymphoma (ATLL)</subject><subject>Aged</subject><subject>Autoantibodies - blood</subject><subject>Blotting, Southern</subject><subject>cytotoxic Tcell (CTL)</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Human T-lymphotropic virus 1</subject><subject>human Tlymphotropic virus type I (HTLVI)</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Leukemia-Lymphoma, Adult T-Cell - blood</subject><subject>Leukemia-Lymphoma, Adult T-Cell - drug therapy</subject><subject>Leukemia-Lymphoma, Adult T-Cell - immunology</subject><subject>Lung Diseases, Interstitial - complications</subject><subject>Methylprednisolone - therapeutic use</subject><subject>mixed connective tissue disease (MCTD)</subject><subject>Mixed Connective Tissue Disease - complications</subject><subject>Mixed Connective Tissue Disease - diagnosis</subject><subject>Mixed Connective Tissue Disease - drug therapy</subject><subject>Mixed Connective Tissue Disease - immunology</subject><subject>Prednisolone - therapeutic use</subject><subject>Receptors, Interleukin-2 - blood</subject><subject>Thymidine Kinase - blood</subject><issn>0918-2918</issn><issn>1349-7235</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhi0EokvhFZBPcMo2juM4PlaB0pVScVm4RrPOmHVJnGA7FfscvDDe7qpICDGHmcP_zT-Wf0Ioy9cFq9SVdRG9g2HE3mrrcF2KNStV_oysGC9VJgsunpNVrlidFaldkFch3Oc5r6UqXpILVgkllKpX5NdmHBc3hWWePYZgH5BuPUIc0UVqJk_v7E_saTM5hzo-yjaEBekHGxAC0js40BvQdrARItK4TxI-4DDNjxaTodf9MkS6pQ0OA21x-Y6jhav2MM77aQRqHQV6u22_bmgD3lv0r8kLA0PAN-d5Sb7cfNw2t1n7-dOmuW4zzaXIs0JUotRMcsPVbqe1kkKXlTE9sL6uCiWMrnIGYFiveiYNL7iGXqUSFe5A8kvy_uQ7--nHgiF2ow06vRIcTkvoVC6ZPH5TIt_9l6xkzXld8gTWJ1D7KQSPppu9HcEfOpZ3x-i6v6PrStEdo0urb883ll0S_yyes0pAewLuQ4Rv-ASAj1YP-E9ncWqFkk-Y3oPv0PHf7JS5LQ</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Fujiwara, Hiroshi</creator><creator>Nakamura, Daisuke</creator><creator>Kukita, Toshimasa</creator><creator>Hamada, Heiichiro</creator><creator>Ozaki, Atsuo</creator><creator>Matsushita, Kakushi</creator><creator>Matsumoto, Tadashi</creator><creator>Tei, Chuwa</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>2006</creationdate><title>Immunosuppressive Treatment for Mixed Connective Tissue Disease May Facilitate the Development of Adult T Cell Leukemia/Lymphoma in a HTLVI Carrier</title><author>Fujiwara, Hiroshi ; Nakamura, Daisuke ; Kukita, Toshimasa ; Hamada, Heiichiro ; Ozaki, Atsuo ; Matsushita, Kakushi ; Matsumoto, Tadashi ; Tei, Chuwa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3750-25654c173f39bbcc975c46ffda1d86295fc601aaf1d9d17f323cad999956eba73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>adult Tcell leukemia/lymphoma (ATLL)</topic><topic>Aged</topic><topic>Autoantibodies - blood</topic><topic>Blotting, Southern</topic><topic>cytotoxic Tcell (CTL)</topic><topic>Fatal Outcome</topic><topic>Female</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Human T-lymphotropic virus 1</topic><topic>human Tlymphotropic virus type I (HTLVI)</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Leukemia-Lymphoma, Adult T-Cell - blood</topic><topic>Leukemia-Lymphoma, Adult T-Cell - drug therapy</topic><topic>Leukemia-Lymphoma, Adult T-Cell - immunology</topic><topic>Lung Diseases, Interstitial - complications</topic><topic>Methylprednisolone - therapeutic use</topic><topic>mixed connective tissue disease (MCTD)</topic><topic>Mixed Connective Tissue Disease - complications</topic><topic>Mixed Connective Tissue Disease - diagnosis</topic><topic>Mixed Connective Tissue Disease - drug therapy</topic><topic>Mixed Connective Tissue Disease - immunology</topic><topic>Prednisolone - therapeutic use</topic><topic>Receptors, Interleukin-2 - blood</topic><topic>Thymidine Kinase - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujiwara, Hiroshi</creatorcontrib><creatorcontrib>Nakamura, Daisuke</creatorcontrib><creatorcontrib>Kukita, Toshimasa</creatorcontrib><creatorcontrib>Hamada, Heiichiro</creatorcontrib><creatorcontrib>Ozaki, Atsuo</creatorcontrib><creatorcontrib>Matsushita, Kakushi</creatorcontrib><creatorcontrib>Matsumoto, Tadashi</creatorcontrib><creatorcontrib>Tei, Chuwa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujiwara, Hiroshi</au><au>Nakamura, Daisuke</au><au>Kukita, Toshimasa</au><au>Hamada, Heiichiro</au><au>Ozaki, Atsuo</au><au>Matsushita, Kakushi</au><au>Matsumoto, Tadashi</au><au>Tei, Chuwa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunosuppressive Treatment for Mixed Connective Tissue Disease May Facilitate the Development of Adult T Cell Leukemia/Lymphoma in a HTLVI Carrier</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2006</date><risdate>2006</risdate><volume>45</volume><issue>5</issue><spage>297</spage><epage>301</epage><pages>297-301</pages><issn>0918-2918</issn><issn>1349-7235</issn><eissn>1349-7235</eissn><abstract>A 66yearold woman who was positive for human Tlymphotropic virus type I (HTLVI) antibody developed mixed connective tissue disease (MCTD) with interstitial pneumonia, and was successfully treated with corticosteroid. One year later, under maintenance treatment of prednisolone (PSL), she contracted acute type adult Tcell leukemia/lymphoma (ATLL) without flaring of MCTD. MCTD is considered to be as one of the HTLVIrelated inflammatory diseases, however the development of ATLL during the treatment of HTLVIrelated MCTD has not been well studied. Here, we review the literature and raise the issue of the mutual interactions between MCTDcausative antiHTLVI immune response and antiATLL immune response.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>16595998</pmid><doi>10.2169/internalmedicine.45.1490</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | adult Tcell leukemia/lymphoma (ATLL) Aged Autoantibodies - blood Blotting, Southern cytotoxic Tcell (CTL) Fatal Outcome Female Glucocorticoids - therapeutic use Human T-lymphotropic virus 1 human Tlymphotropic virus type I (HTLVI) Humans Immunosuppressive Agents - therapeutic use Leukemia-Lymphoma, Adult T-Cell - blood Leukemia-Lymphoma, Adult T-Cell - drug therapy Leukemia-Lymphoma, Adult T-Cell - immunology Lung Diseases, Interstitial - complications Methylprednisolone - therapeutic use mixed connective tissue disease (MCTD) Mixed Connective Tissue Disease - complications Mixed Connective Tissue Disease - diagnosis Mixed Connective Tissue Disease - drug therapy Mixed Connective Tissue Disease - immunology Prednisolone - therapeutic use Receptors, Interleukin-2 - blood Thymidine Kinase - blood |
| title | Immunosuppressive Treatment for Mixed Connective Tissue Disease May Facilitate the Development of Adult T Cell Leukemia/Lymphoma in a HTLVI Carrier |
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