Elimination of Adult-Born Neurons in the Olfactory Bulb Is Promoted during the Postprandial Period
Granule cells (GCs) in the mouse olfactory bulb (OB) continue to be generated in adulthood, with nearly half incorporated and the remainder eliminated. Here, we show that elimination of adult-born GCs is promoted during a short time window in the postprandial period. Under restricted feeding, the nu...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 2011-09, Vol.71 (5), p.883-897 |
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| creator | Yokoyama, Takeshi K. Mochimaru, Daisuke Murata, Koshi Manabe, Hiroyuki Kobayakawa, Ko Kobayakawa, Reiko Sakano, Hitoshi Mori, Kensaku Yamaguchi, Masahiro |
| description | Granule cells (GCs) in the mouse olfactory bulb (OB) continue to be generated in adulthood, with nearly half incorporated and the remainder eliminated. Here, we show that elimination of adult-born GCs is promoted during a short time window in the postprandial period. Under restricted feeding, the number of apoptotic GCs specifically increased within a few hours after the start of feeding. This enhanced GC apoptosis occurred in association with postprandial behaviors that included grooming, resting, and sleeping, and was particularly correlated with the length of postprandial sleep. Further, deprivation of olfactory sensory experience in the local OB area potentiated the extent of GC elimination in that area during the postprandial period. Sensory experience-dependent enhancement of GC elimination also occurred during postprandial period under natural feeding condition. These results suggest that extensive structural reorganization of bulbar circuitry occurs during the postprandial period, reflecting sensory experience during preceding waking period.
► Elimination of adult-born OB neurons is promoted during short postprandial period ► Feeding and postprandial behaviors define the time window of cell elimination ► Sensory inputs to local OB area locally regulate the postprandial cell elimination |
| doi_str_mv | 10.1016/j.neuron.2011.05.046 |
| format | Article |
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► Elimination of adult-born OB neurons is promoted during short postprandial period ► Feeding and postprandial behaviors define the time window of cell elimination ► Sensory inputs to local OB area locally regulate the postprandial cell elimination</description><identifier>ISSN: 0896-6273</identifier><identifier>EISSN: 1097-4199</identifier><identifier>DOI: 10.1016/j.neuron.2011.05.046</identifier><identifier>PMID: 21903081</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Age Factors ; Animals ; Animals, Newborn ; Apoptosis ; Apoptosis - physiology ; Behavior ; Bromodeoxyuridine - metabolism ; Caspase 3 - metabolism ; Cell Count - methods ; Circadian Rhythm ; Colleges & universities ; Drinking Behavior - physiology ; Experiments ; Exploratory Behavior - physiology ; Feeding Behavior ; Food ; Food Deprivation - physiology ; Grooming ; Hippocampus - cytology ; Hippocampus - growth & development ; In Situ Nick-End Labeling - methods ; Male ; Mice ; Mice, Inbred C57BL ; Microtubule-Associated Proteins - metabolism ; Models, Biological ; Neurogenesis - physiology ; Neurons ; Neuropeptides - metabolism ; Odorants ; Olfactory Bulb - cytology ; Olfactory Bulb - injuries ; Olfactory Receptor Neurons - physiology ; Postprandial Period - physiology ; Sensory Deprivation - physiology ; Time Factors</subject><ispartof>Neuron (Cambridge, Mass.), 2011-09, Vol.71 (5), p.883-897</ispartof><rights>2011 Elsevier Inc.</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Sep 8, 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-21a11541ebb534eef9c9bfafe98ff324953eddfdd87a179aff7ab1c5e0116db53</citedby><cites>FETCH-LOGICAL-c533t-21a11541ebb534eef9c9bfafe98ff324953eddfdd87a179aff7ab1c5e0116db53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S089662731100506X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21903081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yokoyama, Takeshi K.</creatorcontrib><creatorcontrib>Mochimaru, Daisuke</creatorcontrib><creatorcontrib>Murata, Koshi</creatorcontrib><creatorcontrib>Manabe, Hiroyuki</creatorcontrib><creatorcontrib>Kobayakawa, Ko</creatorcontrib><creatorcontrib>Kobayakawa, Reiko</creatorcontrib><creatorcontrib>Sakano, Hitoshi</creatorcontrib><creatorcontrib>Mori, Kensaku</creatorcontrib><creatorcontrib>Yamaguchi, Masahiro</creatorcontrib><title>Elimination of Adult-Born Neurons in the Olfactory Bulb Is Promoted during the Postprandial Period</title><title>Neuron (Cambridge, Mass.)</title><addtitle>Neuron</addtitle><description>Granule cells (GCs) in the mouse olfactory bulb (OB) continue to be generated in adulthood, with nearly half incorporated and the remainder eliminated. Here, we show that elimination of adult-born GCs is promoted during a short time window in the postprandial period. Under restricted feeding, the number of apoptotic GCs specifically increased within a few hours after the start of feeding. This enhanced GC apoptosis occurred in association with postprandial behaviors that included grooming, resting, and sleeping, and was particularly correlated with the length of postprandial sleep. Further, deprivation of olfactory sensory experience in the local OB area potentiated the extent of GC elimination in that area during the postprandial period. Sensory experience-dependent enhancement of GC elimination also occurred during postprandial period under natural feeding condition. These results suggest that extensive structural reorganization of bulbar circuitry occurs during the postprandial period, reflecting sensory experience during preceding waking period.
► Elimination of adult-born OB neurons is promoted during short postprandial period ► Feeding and postprandial behaviors define the time window of cell elimination ► Sensory inputs to local OB area locally regulate the postprandial cell elimination</description><subject>Age Factors</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Apoptosis</subject><subject>Apoptosis - physiology</subject><subject>Behavior</subject><subject>Bromodeoxyuridine - metabolism</subject><subject>Caspase 3 - metabolism</subject><subject>Cell Count - methods</subject><subject>Circadian Rhythm</subject><subject>Colleges & universities</subject><subject>Drinking Behavior - physiology</subject><subject>Experiments</subject><subject>Exploratory Behavior - physiology</subject><subject>Feeding Behavior</subject><subject>Food</subject><subject>Food Deprivation - physiology</subject><subject>Grooming</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - growth & development</subject><subject>In Situ Nick-End Labeling - methods</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microtubule-Associated Proteins - metabolism</subject><subject>Models, Biological</subject><subject>Neurogenesis - physiology</subject><subject>Neurons</subject><subject>Neuropeptides - metabolism</subject><subject>Odorants</subject><subject>Olfactory Bulb - cytology</subject><subject>Olfactory Bulb - injuries</subject><subject>Olfactory Receptor Neurons - physiology</subject><subject>Postprandial Period - physiology</subject><subject>Sensory Deprivation - physiology</subject><subject>Time Factors</subject><issn>0896-6273</issn><issn>1097-4199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EokvhHyBkiQOnBE8cJ_EFqa0KVKroHuBsOfYYvErsxXYq9d-T3S0cOMBpLt-8eW8eIa-B1cCge7-rAy4phrphADUTNWu7J2QDTPZVC1I-JRs2yK7qmp6fkRc57xiDVkh4Ts4akIyzATZkvJ787IMuPgYaHb2wy1Sqy5gC_XKUz9QHWn4gvZucNiWmB3q5TCO9yXSb4hwLWmqX5MP3I7WNueyTDtbriW4x-WhfkmdOTxlfPc5z8u3j9derz9Xt3aebq4vbygjOS9WABhAt4DgK3iI6aeTotEM5OMebVgqO1jprh15DL7VzvR7BCFzjd3bdOSfvTrr7FH8umIuafTY4TTpgXLKSrIdeNG33X3IYBs57wQ_k27_IXVxSWGOo1auUQjJ2oNoTZVLMOaFT--RnnR4UMHUoS-3UqSx1KEsxodjRxptH8WWc0f5Z-t3OCnw4Abi-7d5jUtl4DAatT2iKstH_-8IvSCuoAA</recordid><startdate>20110908</startdate><enddate>20110908</enddate><creator>Yokoyama, Takeshi K.</creator><creator>Mochimaru, Daisuke</creator><creator>Murata, Koshi</creator><creator>Manabe, Hiroyuki</creator><creator>Kobayakawa, Ko</creator><creator>Kobayakawa, Reiko</creator><creator>Sakano, Hitoshi</creator><creator>Mori, Kensaku</creator><creator>Yamaguchi, Masahiro</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20110908</creationdate><title>Elimination of Adult-Born Neurons in the Olfactory Bulb Is Promoted during the Postprandial Period</title><author>Yokoyama, Takeshi K. ; Mochimaru, Daisuke ; Murata, Koshi ; Manabe, Hiroyuki ; Kobayakawa, Ko ; Kobayakawa, Reiko ; Sakano, Hitoshi ; Mori, Kensaku ; Yamaguchi, Masahiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-21a11541ebb534eef9c9bfafe98ff324953eddfdd87a179aff7ab1c5e0116db53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Apoptosis</topic><topic>Apoptosis - physiology</topic><topic>Behavior</topic><topic>Bromodeoxyuridine - metabolism</topic><topic>Caspase 3 - metabolism</topic><topic>Cell Count - methods</topic><topic>Circadian Rhythm</topic><topic>Colleges & universities</topic><topic>Drinking Behavior - physiology</topic><topic>Experiments</topic><topic>Exploratory Behavior - physiology</topic><topic>Feeding Behavior</topic><topic>Food</topic><topic>Food Deprivation - physiology</topic><topic>Grooming</topic><topic>Hippocampus - cytology</topic><topic>Hippocampus - growth & development</topic><topic>In Situ Nick-End Labeling - methods</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microtubule-Associated Proteins - metabolism</topic><topic>Models, Biological</topic><topic>Neurogenesis - physiology</topic><topic>Neurons</topic><topic>Neuropeptides - metabolism</topic><topic>Odorants</topic><topic>Olfactory Bulb - cytology</topic><topic>Olfactory Bulb - injuries</topic><topic>Olfactory Receptor Neurons - physiology</topic><topic>Postprandial Period - physiology</topic><topic>Sensory Deprivation - physiology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yokoyama, Takeshi K.</creatorcontrib><creatorcontrib>Mochimaru, Daisuke</creatorcontrib><creatorcontrib>Murata, Koshi</creatorcontrib><creatorcontrib>Manabe, Hiroyuki</creatorcontrib><creatorcontrib>Kobayakawa, Ko</creatorcontrib><creatorcontrib>Kobayakawa, Reiko</creatorcontrib><creatorcontrib>Sakano, Hitoshi</creatorcontrib><creatorcontrib>Mori, Kensaku</creatorcontrib><creatorcontrib>Yamaguchi, Masahiro</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuron (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yokoyama, Takeshi K.</au><au>Mochimaru, Daisuke</au><au>Murata, Koshi</au><au>Manabe, Hiroyuki</au><au>Kobayakawa, Ko</au><au>Kobayakawa, Reiko</au><au>Sakano, Hitoshi</au><au>Mori, Kensaku</au><au>Yamaguchi, Masahiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elimination of Adult-Born Neurons in the Olfactory Bulb Is Promoted during the Postprandial Period</atitle><jtitle>Neuron (Cambridge, Mass.)</jtitle><addtitle>Neuron</addtitle><date>2011-09-08</date><risdate>2011</risdate><volume>71</volume><issue>5</issue><spage>883</spage><epage>897</epage><pages>883-897</pages><issn>0896-6273</issn><eissn>1097-4199</eissn><abstract>Granule cells (GCs) in the mouse olfactory bulb (OB) continue to be generated in adulthood, with nearly half incorporated and the remainder eliminated. Here, we show that elimination of adult-born GCs is promoted during a short time window in the postprandial period. Under restricted feeding, the number of apoptotic GCs specifically increased within a few hours after the start of feeding. This enhanced GC apoptosis occurred in association with postprandial behaviors that included grooming, resting, and sleeping, and was particularly correlated with the length of postprandial sleep. Further, deprivation of olfactory sensory experience in the local OB area potentiated the extent of GC elimination in that area during the postprandial period. Sensory experience-dependent enhancement of GC elimination also occurred during postprandial period under natural feeding condition. These results suggest that extensive structural reorganization of bulbar circuitry occurs during the postprandial period, reflecting sensory experience during preceding waking period.
► Elimination of adult-born OB neurons is promoted during short postprandial period ► Feeding and postprandial behaviors define the time window of cell elimination ► Sensory inputs to local OB area locally regulate the postprandial cell elimination</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21903081</pmid><doi>10.1016/j.neuron.2011.05.046</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Factors Animals Animals, Newborn Apoptosis Apoptosis - physiology Behavior Bromodeoxyuridine - metabolism Caspase 3 - metabolism Cell Count - methods Circadian Rhythm Colleges & universities Drinking Behavior - physiology Experiments Exploratory Behavior - physiology Feeding Behavior Food Food Deprivation - physiology Grooming Hippocampus - cytology Hippocampus - growth & development In Situ Nick-End Labeling - methods Male Mice Mice, Inbred C57BL Microtubule-Associated Proteins - metabolism Models, Biological Neurogenesis - physiology Neurons Neuropeptides - metabolism Odorants Olfactory Bulb - cytology Olfactory Bulb - injuries Olfactory Receptor Neurons - physiology Postprandial Period - physiology Sensory Deprivation - physiology Time Factors |
| title | Elimination of Adult-Born Neurons in the Olfactory Bulb Is Promoted during the Postprandial Period |
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