The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y sub(2) receptor

A series of small molecules based on a chemotype identified from our compound collection were synthesized and tested for binding affinity (IC sub(50)) at the human Neuropeptide Y Y sub(2) receptor (NPY Y sub(2)). Six of the 23 analogs tested possessed an NPY Y sub(2) IC sub(50) [less-than-or-equals,...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2011-09, Vol.21 (18), p.5552-5556
Hauptverfasser:	Swanson, Devin M, Wong, Victoria D, Jablonowski, Jill A, Shah, Chandra, Rudolph, Dale A, Dvorak, Curt A, Seierstad, Mark, Dvorak, Lisa K, Morton, Kirsten, Nepomuceno, Diane, Atack, John R, Bonaventure, Pascal, Lovenberg, Timothy W, Carruthers, Nicholas I
Format:	Artikel
Sprache:	eng
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