Inactivation of O6-methyguanine-DNA methyltransferase by promoter hypermethylation: Association of epithelial ovarian carcinogenesis in specific histological types

Aim: The aim of this study was to evaluate O6‐methyguanine‐DNA methyltransferase (MGMT) promoter hypermethylation, MGMT expression and microsatellite instability (MSI), as well as to elucidate their correlation with clinical and pathological parameters in epithelial ovarian cancer. Methods: Ovaria...

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Veröffentlicht in:	The journal of obstetrics and gynaecology research 2011-07, Vol.37 (7), p.851-860
Hauptverfasser:	Roh, Hyun-Jin, Suh, Dong-Soo, Choi, Kyung-Un, Yoo, Hang-Jo, Joo, Won-Deok, Yoon, Man-Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Carcinogenesis Carcinoma Clear cells CpG islands DNA hypermethylation DNA Methylation Down-Regulation Female Humans Immunohistochemistry Microsatellite instability Middle Aged negative MGMT expression Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasms, Glandular and Epithelial - metabolism Neoplasms, Glandular and Epithelial - pathology O-Methylguanine-DNA Methyltransferase - antagonists & inhibitors O-Methylguanine-DNA Methyltransferase - genetics O-Methylguanine-DNA Methyltransferase - metabolism O6-methyguanine-DNA methyltransferase O6-methylguanine-DNA methyltransferase Obstetrics Ovarian cancer Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Polymerase chain reaction Promoter Regions, Genetic Promoters Tumors Young Adult
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