P29 Reduced expression of Tim-3 renders Th1 and Th17 effector cells less amenable to T-reg control in autoimmune hepatitis

IntroductionIn autoimmune hepatitis (AIH), CD4 effector immune responses are permitted by defective CD4+CD25+ regulatory T-cells (T-regs). In murine studies apoptosis of Th1 effector cells is mediated by binding of T-cell-immunoglobulin-and-mucin-domain3 (Tim-3) on their surface to Galectin-9 (Gal9)...

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Veröffentlicht in:	Gut 2011-09, Vol.60 (Suppl 2), p.A13-A14
Hauptverfasser:	Liberal, R, Mieli-Vergani, G, Vergani, D, Longhi, M S
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Apoptosis CD25 antigen CD4 antigen Cell culture Cell growth Cell proliferation Digestive tract Effector cells Galectin-9 GATA-3 protein Helper cells Hepatitis Immune response Liver Lymphocytes T Monoclonal antibodies Mucin Phenotypes T cell receptors Thymidine Transcription factors
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