In vitro transforming potential, intracellular signaling properties, and sensitivity to a kinase inhibitor (sorafenib) of RET proto-oncogene variants Glu511Lys, Ser649Leu, and Arg886Trp

Multiple endocrine neoplasia type 2 and a subset of apparently sporadic medullary thyroid carcinoma (AS-MTC) are caused by germ line activating point mutations of the rearranged during transfection (RET) proto-oncogene. RET encodes a receptor with tyrosine kinase activity that targets several intrac...

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Veröffentlicht in:	Endocrine-related cancer 2011-08, Vol.18 (4), p.401-412
Hauptverfasser:	Prazeres, Hugo, Couto, Joana P, Rodrigues, Fernando, Vinagre, João, Torres, Joana, Trovisco, Vitor, Martins, Teresa C, Sobrinho-Simões, Manuel, Soares, Paula
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism Benzenesulfonates - pharmacology Blotting, Western Carcinoma, Medullary - genetics Carcinoma, Medullary - metabolism Case-Control Studies Cell Transformation, Neoplastic Cells, Cultured Female Germ-Line Mutation - genetics Humans Kidney - cytology Kidney - drug effects Kidney - metabolism Luciferases - metabolism Male Mice Middle Aged Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Mutagenesis, Site-Directed Niacinamide - analogs & derivatives NIH 3T3 Cells Pedigree Phenylurea Compounds Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-ret - genetics Proto-Oncogene Proteins c-ret - metabolism Pyridines - pharmacology Regular papers Signal Transduction STAT3 Transcription Factor - metabolism Thyroid Neoplasms - genetics Thyroid Neoplasms - metabolism Transcription Factor 4 Transcription Factors - metabolism Young Adult
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