Nucleic acids targeted to drugs: SELEX against a quadruplex ligand

A number of small molecules demonstrate selective recognition of G-quadruplexes and are able to stabilize their formation. In this work, we performed the synthesis of two biotin-tagged G4 ligands and analyzed their interactions with DNA by two complementary techniques, FRET and FID. The compound tha...

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Veröffentlicht in:	Biochimie 2011-08, Vol.93 (8), p.1357-1367
Hauptverfasser:	Renaud de la Faverie, Amandine, Hamon, Florian, Di Primo, Carmelo, Largy, Eric, Dausse, Eric, Delaurière, Laurence, Landras-Guetta, Corinne, Toulmé, Jean-Jacques, Teulade-Fichou, Marie-Paule, Mergny, Jean-Louis
Format:	Artikel
Sprache:	eng
Schlagworte:	Aptamer Biotin - chemistry Circular Dichroism Copper - chemistry Drug Design Drug–DNA interactions Fluorescence Resonance Energy Transfer G-Quadruplexes Intercalating Agents - chemistry Ligands Quadruplexes SELEX SELEX Aptamer Technique SPR Surface Plasmon Resonance Unusual nucleic acids structure
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