MALDI-TOF MS profiling as the first-tier screen for sickle cell disease in neonates: Matching throughput to objectives

Purpose: Universal newborn screening for sickle cell diseases (SCDs) is not currently performed in many countries concerned by this public health problem. Owing to the technical and financial limitations of standard profiling methods (IEF coupled to subsequent HPLC), ethnically targeted neonatal scr...

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Veröffentlicht in:	Proteomics. Clinical applications 2011-08, Vol.5 (7-8), p.405-414
Hauptverfasser:	Hachani, Johan, Duban-Deweer, Sophie, Pottiez, Gwënaël, Renom, Gilles, Flahaut, Christophe, Périni, Jean-Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia, Sickle Cell - diagnosis Anemia, Sickle Cell - economics Anemia, Sickle Cell - pathology Anemias. Hemoglobinopathies Biological and medical sciences Case-Control Studies Cost-Benefit Analysis Diseases of red blood cells Diverse techniques Female Fundamental and applied biological sciences. Psychology Hematologic and hematopoietic diseases Hemoglobin, Sickle - analysis High-Throughput Screening Assays - economics High-Throughput Screening Assays - methods Humans Infant, Newborn Male Medical sciences Medical screening Molecular and cellular biology Neonatal screening Neonatal Screening - economics Neonatal Screening - methods Objectives Public Health Quality Control Retrospective Studies Sensitivity and Specificity Sickle cell anemia Sickle cell disease Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - economics Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Thalassaemia
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