Successful Treatment of Ulcerative Colitis Associated with Hypereosinophilic Syndrome/Chronic Eosinophilic Leukemia
A 23-year-old female was diagnosed as having simultaneous ulcerative colitis (UC) relapse and hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL) without FIP1L1-platelet-derived growth factor receptor alpha (PDGFRA) (F/P) fusion gene. Pathological findings of colon specimens were co...
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| Veröffentlicht in: | Internal Medicine 2011, Vol.50(16), pp.1741-1745 |
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| creator | Awano, Nobuyasu Ryu, Tomiko Yoshimura, Naoki Takazoe, Masakazu Kitamura, Shigehiro Tanaka, Masanori |
| description | A 23-year-old female was diagnosed as having simultaneous ulcerative colitis (UC) relapse and hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL) without FIP1L1-platelet-derived growth factor receptor alpha (PDGFRA) (F/P) fusion gene. Pathological findings of colon specimens were compatible with UC, however, focal severe infiltration of eosinophils was observed in the rectum, which is unusual in UC, suggesting eosinophil-mediated organ damage. Although imatinib mesylate (IM) is usually ineffective for the treatment of HES/CEL with negative-F/P fusion gene, in the present case it led to the remission of HES/CEL and UC at a higher drug dosage level (400 mg/day). That suggested the presence of unknown tyrosine kinase abnormalities not yet categorized. |
| doi_str_mv | 10.2169/internalmedicine.50.5569 |
| format | Article |
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Pathological findings of colon specimens were compatible with UC, however, focal severe infiltration of eosinophils was observed in the rectum, which is unusual in UC, suggesting eosinophil-mediated organ damage. Although imatinib mesylate (IM) is usually ineffective for the treatment of HES/CEL with negative-F/P fusion gene, in the present case it led to the remission of HES/CEL and UC at a higher drug dosage level (400 mg/day). That suggested the presence of unknown tyrosine kinase abnormalities not yet categorized.</description><identifier>ISSN: 0918-2918</identifier><identifier>ISSN: 1349-7235</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.50.5569</identifier><identifier>PMID: 21841337</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Benzamides ; Chronic Disease ; chronic eosinophilic leukemia (CEL) ; Colitis, Ulcerative - complications ; Colitis, Ulcerative - diagnosis ; Colitis, Ulcerative - drug therapy ; Female ; FIP1L1-platelet-derived growth factor receptor alpha (FIP1L1-PDGFRA) ; Humans ; Hypereosinophilic Syndrome - complications ; Hypereosinophilic Syndrome - diagnosis ; Hypereosinophilic Syndrome - drug therapy ; hypereosinopilic syndrome (HES) ; Imatinib Mesylate ; Piperazines - therapeutic use ; Pyrimidines - therapeutic use ; Treatment Outcome ; ulcerative colitis ; Young Adult</subject><ispartof>Internal Medicine, 2011, Vol.50(16), pp.1741-1745</ispartof><rights>2011 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-71637587417cf69b9542278c442a5dc869291dadd9b24ca2d3fc8748f93e14383</citedby><cites>FETCH-LOGICAL-c508t-71637587417cf69b9542278c442a5dc869291dadd9b24ca2d3fc8748f93e14383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21841337$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Awano, Nobuyasu</creatorcontrib><creatorcontrib>Ryu, Tomiko</creatorcontrib><creatorcontrib>Yoshimura, Naoki</creatorcontrib><creatorcontrib>Takazoe, Masakazu</creatorcontrib><creatorcontrib>Kitamura, Shigehiro</creatorcontrib><creatorcontrib>Tanaka, Masanori</creatorcontrib><title>Successful Treatment of Ulcerative Colitis Associated with Hypereosinophilic Syndrome/Chronic Eosinophilic Leukemia</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>A 23-year-old female was diagnosed as having simultaneous ulcerative colitis (UC) relapse and hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL) without FIP1L1-platelet-derived growth factor receptor alpha (PDGFRA) (F/P) fusion gene. Pathological findings of colon specimens were compatible with UC, however, focal severe infiltration of eosinophils was observed in the rectum, which is unusual in UC, suggesting eosinophil-mediated organ damage. Although imatinib mesylate (IM) is usually ineffective for the treatment of HES/CEL with negative-F/P fusion gene, in the present case it led to the remission of HES/CEL and UC at a higher drug dosage level (400 mg/day). That suggested the presence of unknown tyrosine kinase abnormalities not yet categorized.</description><subject>Benzamides</subject><subject>Chronic Disease</subject><subject>chronic eosinophilic leukemia (CEL)</subject><subject>Colitis, Ulcerative - complications</subject><subject>Colitis, Ulcerative - diagnosis</subject><subject>Colitis, Ulcerative - drug therapy</subject><subject>Female</subject><subject>FIP1L1-platelet-derived growth factor receptor alpha (FIP1L1-PDGFRA)</subject><subject>Humans</subject><subject>Hypereosinophilic Syndrome - complications</subject><subject>Hypereosinophilic Syndrome - diagnosis</subject><subject>Hypereosinophilic Syndrome - drug therapy</subject><subject>hypereosinopilic syndrome (HES)</subject><subject>Imatinib Mesylate</subject><subject>Piperazines - therapeutic use</subject><subject>Pyrimidines - therapeutic use</subject><subject>Treatment Outcome</subject><subject>ulcerative colitis</subject><subject>Young Adult</subject><issn>0918-2918</issn><issn>1349-7235</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rGzEQhkVoady0f6Ho1tM6-litpGMwaRIw5JDkLGTtbK1kV3IlbYv_fRTsmlIKvczAvM_MMPMihClZMtrpSx8KpGDHCXrvfIClIEshOn2GFpS3upGMi3doQTRVDavhHH3M-ZkQrqRmH9A5o6qlnMsFyg-zc5DzMI_4MYEtE4SC44CfRgfJFv8T8CqOvviMr3KOztsCPf7lyxbf7neQIGYf4m7rR-_wwz70KU5wudqmGGrh-k91DfMLTN5-Qu8HO2b4fMwX6Onb9ePqtlnf39ytrtaNE0SVRtKOS6FkS6UbOr3RomVMKte2zIreqU7X03rb93rDWmdZzwdXaTVoDrTlil-gr4e5uxR_zJCLmXx2MI42QJyz0URSybSS_yWV4kqQ-uFKqgPpUsw5wWB2yU827Q0l5s0b87c3RhDz5k1t_XJcMm-qeGr8bUYF7g_Acy72O5wAm4p3I_xzMu2OkdY_nUi3tclA4K9Rxa8Z</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Awano, Nobuyasu</creator><creator>Ryu, Tomiko</creator><creator>Yoshimura, Naoki</creator><creator>Takazoe, Masakazu</creator><creator>Kitamura, Shigehiro</creator><creator>Tanaka, Masanori</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20110101</creationdate><title>Successful Treatment of Ulcerative Colitis Associated with Hypereosinophilic Syndrome/Chronic Eosinophilic Leukemia</title><author>Awano, Nobuyasu ; Ryu, Tomiko ; Yoshimura, Naoki ; Takazoe, Masakazu ; Kitamura, Shigehiro ; Tanaka, Masanori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-71637587417cf69b9542278c442a5dc869291dadd9b24ca2d3fc8748f93e14383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Benzamides</topic><topic>Chronic Disease</topic><topic>chronic eosinophilic leukemia (CEL)</topic><topic>Colitis, Ulcerative - complications</topic><topic>Colitis, Ulcerative - diagnosis</topic><topic>Colitis, Ulcerative - drug therapy</topic><topic>Female</topic><topic>FIP1L1-platelet-derived growth factor receptor alpha (FIP1L1-PDGFRA)</topic><topic>Humans</topic><topic>Hypereosinophilic Syndrome - complications</topic><topic>Hypereosinophilic Syndrome - diagnosis</topic><topic>Hypereosinophilic Syndrome - drug therapy</topic><topic>hypereosinopilic syndrome (HES)</topic><topic>Imatinib Mesylate</topic><topic>Piperazines - therapeutic use</topic><topic>Pyrimidines - therapeutic use</topic><topic>Treatment Outcome</topic><topic>ulcerative colitis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Awano, Nobuyasu</creatorcontrib><creatorcontrib>Ryu, Tomiko</creatorcontrib><creatorcontrib>Yoshimura, Naoki</creatorcontrib><creatorcontrib>Takazoe, Masakazu</creatorcontrib><creatorcontrib>Kitamura, Shigehiro</creatorcontrib><creatorcontrib>Tanaka, Masanori</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Awano, Nobuyasu</au><au>Ryu, Tomiko</au><au>Yoshimura, Naoki</au><au>Takazoe, Masakazu</au><au>Kitamura, Shigehiro</au><au>Tanaka, Masanori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful Treatment of Ulcerative Colitis Associated with Hypereosinophilic Syndrome/Chronic Eosinophilic Leukemia</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>50</volume><issue>16</issue><spage>1741</spage><epage>1745</epage><pages>1741-1745</pages><issn>0918-2918</issn><issn>1349-7235</issn><eissn>1349-7235</eissn><abstract>A 23-year-old female was diagnosed as having simultaneous ulcerative colitis (UC) relapse and hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL) without FIP1L1-platelet-derived growth factor receptor alpha (PDGFRA) (F/P) fusion gene. Pathological findings of colon specimens were compatible with UC, however, focal severe infiltration of eosinophils was observed in the rectum, which is unusual in UC, suggesting eosinophil-mediated organ damage. Although imatinib mesylate (IM) is usually ineffective for the treatment of HES/CEL with negative-F/P fusion gene, in the present case it led to the remission of HES/CEL and UC at a higher drug dosage level (400 mg/day). That suggested the presence of unknown tyrosine kinase abnormalities not yet categorized.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>21841337</pmid><doi>10.2169/internalmedicine.50.5569</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Benzamides Chronic Disease chronic eosinophilic leukemia (CEL) Colitis, Ulcerative - complications Colitis, Ulcerative - diagnosis Colitis, Ulcerative - drug therapy Female FIP1L1-platelet-derived growth factor receptor alpha (FIP1L1-PDGFRA) Humans Hypereosinophilic Syndrome - complications Hypereosinophilic Syndrome - diagnosis Hypereosinophilic Syndrome - drug therapy hypereosinopilic syndrome (HES) Imatinib Mesylate Piperazines - therapeutic use Pyrimidines - therapeutic use Treatment Outcome ulcerative colitis Young Adult |
| title | Successful Treatment of Ulcerative Colitis Associated with Hypereosinophilic Syndrome/Chronic Eosinophilic Leukemia |
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