The Methyltransferase Set7/9 (Setd7) Is Dispensable for the p53-Mediated DNA Damage Response In Vivo

p53 is the central regulator of cell fate following genotoxic stress and oncogene activation. Its activity is controlled by several posttranslational modifications. Originally defined as a critical layer of p53 regulation in human cell lines, p53 lysine methylation by Set7/9 (also called Setd7) was...

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Veröffentlicht in:	Molecular cell 2011-08, Vol.43 (4), p.681-688
Hauptverfasser:	Campaner, Stefano, Spreafico, Fabio, Burgold, Thomas, Doni, Mirko, Rosato, Umberto, Amati, Bruno, Testa, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals apoptosis Apoptosis - genetics cell cycle Cell Cycle - genetics DNA Damage Gene Deletion gene expression Gene Expression Regulation genotoxicity human cell lines irradiation knockout mutants lysine methylation methyltransferases Mice Mice, Knockout oncogenes post-translational modification Protein Methyltransferases - genetics Protein Methyltransferases - metabolism Protein Methyltransferases - physiology Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Protein p53 - physiology
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