Immunoglobulin D-Lambda Type Multiple Myeloma Presenting with FDG-PET/CT Negative Bone Marrow Involvement
We here report a rare case of a patient with IgD-lambda-positive multiple myeloma presenting with FDG-PET/CT negative bone marrow involvement. A 72-year-old man was admitted to our hospital for evaluation of a paravertebral tumor of the chest. Thoracotomy was performed and a histopathological evalua...
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| Veröffentlicht in: | Internal Medicine 2011, Vol.50(14), pp.1483-1487 |
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| creator | Machida, Hisanori Shinohara, Tsutomu Hino, Hiroyuki Yoshida, Mitsuteru Hatakeyama, Nobuo Okano, Yoshio Inayama, Mami Hosokawa, Emiko Abe, Shuichi Naruse, Keishi Iwahara, Yoshihito Ogushi, Fumitaka |
| description | We here report a rare case of a patient with IgD-lambda-positive multiple myeloma presenting with FDG-PET/CT negative bone marrow involvement. A 72-year-old man was admitted to our hospital for evaluation of a paravertebral tumor of the chest. Thoracotomy was performed and a histopathological evaluation of resected intrathoracic tumor demonstrated a plasmacytic neoplasma. Initially we thought that this case was a solitary plasmacytoma because there were no positive findings on postoperative FDG-PET/CT. However, bone marrow aspiration study demonstrated massive infiltration of myeloma cells (72%). It is necessary to recognize that IgD-lambda type myeloma cells may not be sufficiently metabolically active to form high uptake on FDG-PET/CT. |
| doi_str_mv | 10.2169/internalmedicine.50.5148 |
| format | Article |
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A 72-year-old man was admitted to our hospital for evaluation of a paravertebral tumor of the chest. Thoracotomy was performed and a histopathological evaluation of resected intrathoracic tumor demonstrated a plasmacytic neoplasma. Initially we thought that this case was a solitary plasmacytoma because there were no positive findings on postoperative FDG-PET/CT. However, bone marrow aspiration study demonstrated massive infiltration of myeloma cells (72%). It is necessary to recognize that IgD-lambda type myeloma cells may not be sufficiently metabolically active to form high uptake on FDG-PET/CT.</description><identifier>ISSN: 0918-2918</identifier><identifier>ISSN: 1349-7235</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.50.5148</identifier><identifier>PMID: 21757834</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Aged ; Bone Marrow - diagnostic imaging ; Bone Marrow - pathology ; Diagnosis, Differential ; FDG-PET/CT ; Fluorodeoxyglucose F18 ; Humans ; IgD myeloma ; Immunoglobulin D - metabolism ; Magnetic Resonance Imaging ; Male ; Monoclonal Gammopathy of Undetermined Significance - diagnosis ; Multiple Myeloma - diagnosis ; Multiple Myeloma - diagnostic imaging ; Multiple Myeloma - immunology ; Plasmacytoma - diagnosis ; Plasmacytoma - diagnostic imaging ; Plasmacytoma - immunology ; Positron-Emission Tomography ; Radiopharmaceuticals ; Tomography, X-Ray Computed</subject><ispartof>Internal Medicine, 2011, Vol.50(14), pp.1483-1487</ispartof><rights>2011 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c558t-fba677c2a0e9c5ba6dd7bdf72d9f7b03a6754f8c73f7ae8214482f4f826a9e363</citedby><cites>FETCH-LOGICAL-c558t-fba677c2a0e9c5ba6dd7bdf72d9f7b03a6754f8c73f7ae8214482f4f826a9e363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21757834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Machida, Hisanori</creatorcontrib><creatorcontrib>Shinohara, Tsutomu</creatorcontrib><creatorcontrib>Hino, Hiroyuki</creatorcontrib><creatorcontrib>Yoshida, Mitsuteru</creatorcontrib><creatorcontrib>Hatakeyama, Nobuo</creatorcontrib><creatorcontrib>Okano, Yoshio</creatorcontrib><creatorcontrib>Inayama, Mami</creatorcontrib><creatorcontrib>Hosokawa, Emiko</creatorcontrib><creatorcontrib>Abe, Shuichi</creatorcontrib><creatorcontrib>Naruse, Keishi</creatorcontrib><creatorcontrib>Iwahara, Yoshihito</creatorcontrib><creatorcontrib>Ogushi, Fumitaka</creatorcontrib><title>Immunoglobulin D-Lambda Type Multiple Myeloma Presenting with FDG-PET/CT Negative Bone Marrow Involvement</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>We here report a rare case of a patient with IgD-lambda-positive multiple myeloma presenting with FDG-PET/CT negative bone marrow involvement. A 72-year-old man was admitted to our hospital for evaluation of a paravertebral tumor of the chest. Thoracotomy was performed and a histopathological evaluation of resected intrathoracic tumor demonstrated a plasmacytic neoplasma. Initially we thought that this case was a solitary plasmacytoma because there were no positive findings on postoperative FDG-PET/CT. However, bone marrow aspiration study demonstrated massive infiltration of myeloma cells (72%). It is necessary to recognize that IgD-lambda type myeloma cells may not be sufficiently metabolically active to form high uptake on FDG-PET/CT.</description><subject>Aged</subject><subject>Bone Marrow - diagnostic imaging</subject><subject>Bone Marrow - pathology</subject><subject>Diagnosis, Differential</subject><subject>FDG-PET/CT</subject><subject>Fluorodeoxyglucose F18</subject><subject>Humans</subject><subject>IgD myeloma</subject><subject>Immunoglobulin D - metabolism</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Monoclonal Gammopathy of Undetermined Significance - diagnosis</subject><subject>Multiple Myeloma - diagnosis</subject><subject>Multiple Myeloma - diagnostic imaging</subject><subject>Multiple Myeloma - immunology</subject><subject>Plasmacytoma - diagnosis</subject><subject>Plasmacytoma - diagnostic imaging</subject><subject>Plasmacytoma - immunology</subject><subject>Positron-Emission Tomography</subject><subject>Radiopharmaceuticals</subject><subject>Tomography, X-Ray Computed</subject><issn>0918-2918</issn><issn>1349-7235</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkbtu2zAUhomiReOmfYWCWyc5vIgiNbbOpQbcJoM7CxR15DCgKJekHPjtQ8OOh6BAl3P9_nOGHyFMyZzRqr6yPkHw2g3QWWM9zAWZC1qqd2hGeVkXknHxHs1ITVXBcrhAn2J8IoQrWbOP6IJRKaTi5QzZ5TBMfty4sZ2c9fi6WOmh7TRe77eAf00u2a3LxR7cOGj8ECCCT9Zv8LNNj_j2-q54uFlfLdb4N2x0sjvAP0afBTqE8Rkv_W50Oxiy5jP60GsX4cspX6I_tzfrxc9idX-3XHxfFUYIlYq-1ZWUhmkCtRG56TrZdr1kXd3LlvC8FWWvjOS91KAYLUvF-jxhla6BV_wSfTve3Ybx7wQxNYONBpzTHsYpNjWRVDIhyX9JJWVJScVEJtWRNGGMMUDfbIMddNg3lDQHR5q3jjSCNAdHsvTr6cnU5uVZ-GpBBu6PwFNMegNnQIdkjYN_XqblKR4-nEnzqEMDnr8Avr2qcg</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Machida, Hisanori</creator><creator>Shinohara, Tsutomu</creator><creator>Hino, Hiroyuki</creator><creator>Yoshida, Mitsuteru</creator><creator>Hatakeyama, Nobuo</creator><creator>Okano, Yoshio</creator><creator>Inayama, Mami</creator><creator>Hosokawa, Emiko</creator><creator>Abe, Shuichi</creator><creator>Naruse, Keishi</creator><creator>Iwahara, Yoshihito</creator><creator>Ogushi, Fumitaka</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20110101</creationdate><title>Immunoglobulin D-Lambda Type Multiple Myeloma Presenting with FDG-PET/CT Negative Bone Marrow Involvement</title><author>Machida, Hisanori ; Shinohara, Tsutomu ; Hino, Hiroyuki ; Yoshida, Mitsuteru ; Hatakeyama, Nobuo ; Okano, Yoshio ; Inayama, Mami ; Hosokawa, Emiko ; Abe, Shuichi ; Naruse, Keishi ; Iwahara, Yoshihito ; Ogushi, Fumitaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c558t-fba677c2a0e9c5ba6dd7bdf72d9f7b03a6754f8c73f7ae8214482f4f826a9e363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Bone Marrow - diagnostic imaging</topic><topic>Bone Marrow - pathology</topic><topic>Diagnosis, Differential</topic><topic>FDG-PET/CT</topic><topic>Fluorodeoxyglucose F18</topic><topic>Humans</topic><topic>IgD myeloma</topic><topic>Immunoglobulin D - metabolism</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Monoclonal Gammopathy of Undetermined Significance - diagnosis</topic><topic>Multiple Myeloma - diagnosis</topic><topic>Multiple Myeloma - diagnostic imaging</topic><topic>Multiple Myeloma - immunology</topic><topic>Plasmacytoma - diagnosis</topic><topic>Plasmacytoma - diagnostic imaging</topic><topic>Plasmacytoma - immunology</topic><topic>Positron-Emission Tomography</topic><topic>Radiopharmaceuticals</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Machida, Hisanori</creatorcontrib><creatorcontrib>Shinohara, Tsutomu</creatorcontrib><creatorcontrib>Hino, Hiroyuki</creatorcontrib><creatorcontrib>Yoshida, Mitsuteru</creatorcontrib><creatorcontrib>Hatakeyama, Nobuo</creatorcontrib><creatorcontrib>Okano, Yoshio</creatorcontrib><creatorcontrib>Inayama, Mami</creatorcontrib><creatorcontrib>Hosokawa, Emiko</creatorcontrib><creatorcontrib>Abe, Shuichi</creatorcontrib><creatorcontrib>Naruse, Keishi</creatorcontrib><creatorcontrib>Iwahara, Yoshihito</creatorcontrib><creatorcontrib>Ogushi, Fumitaka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Machida, Hisanori</au><au>Shinohara, Tsutomu</au><au>Hino, Hiroyuki</au><au>Yoshida, Mitsuteru</au><au>Hatakeyama, Nobuo</au><au>Okano, Yoshio</au><au>Inayama, Mami</au><au>Hosokawa, Emiko</au><au>Abe, Shuichi</au><au>Naruse, Keishi</au><au>Iwahara, Yoshihito</au><au>Ogushi, Fumitaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoglobulin D-Lambda Type Multiple Myeloma Presenting with FDG-PET/CT Negative Bone Marrow Involvement</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>50</volume><issue>14</issue><spage>1483</spage><epage>1487</epage><pages>1483-1487</pages><issn>0918-2918</issn><issn>1349-7235</issn><eissn>1349-7235</eissn><abstract>We here report a rare case of a patient with IgD-lambda-positive multiple myeloma presenting with FDG-PET/CT negative bone marrow involvement. A 72-year-old man was admitted to our hospital for evaluation of a paravertebral tumor of the chest. Thoracotomy was performed and a histopathological evaluation of resected intrathoracic tumor demonstrated a plasmacytic neoplasma. Initially we thought that this case was a solitary plasmacytoma because there were no positive findings on postoperative FDG-PET/CT. However, bone marrow aspiration study demonstrated massive infiltration of myeloma cells (72%). 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| subjects | Aged Bone Marrow - diagnostic imaging Bone Marrow - pathology Diagnosis, Differential FDG-PET/CT Fluorodeoxyglucose F18 Humans IgD myeloma Immunoglobulin D - metabolism Magnetic Resonance Imaging Male Monoclonal Gammopathy of Undetermined Significance - diagnosis Multiple Myeloma - diagnosis Multiple Myeloma - diagnostic imaging Multiple Myeloma - immunology Plasmacytoma - diagnosis Plasmacytoma - diagnostic imaging Plasmacytoma - immunology Positron-Emission Tomography Radiopharmaceuticals Tomography, X-Ray Computed |
| title | Immunoglobulin D-Lambda Type Multiple Myeloma Presenting with FDG-PET/CT Negative Bone Marrow Involvement |
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