Type-II cadherins modulate neural activity in cultured rat hippocampal neurons
Cadherins, cell adhesion molecules widely expressed in the nervous system, are thought to be involved in synapse formation and function. To explore the role of cadherins in neuronal activity, we performed electrophysiological and morphological analyses of rat hippocampal cultured neurons overexpress...
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| Veröffentlicht in: | Neuroreport 2011-09, Vol.22 (13), p.629-632 |
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| creator | Matsunaga, Eiji Kurotani, Tohru Suzuki, Kenta Okanoya, Kazuo |
| description | Cadherins, cell adhesion molecules widely expressed in the nervous system, are thought to be involved in synapse formation and function. To explore the role of cadherins in neuronal activity, we performed electrophysiological and morphological analyses of rat hippocampal cultured neurons overexpressing type-II cadherins, such as cadherin-6B and cadherin-7. We found that cadherin-6B increased but cadherin-7 decreased the number of protrusions of dendritic spines, and affected the frequency of miniature excitatory postsynaptic currents. Our results suggest that type-II cadherins may modulate neural activity by regulating neuronal morphology. |
| doi_str_mv | 10.1097/WNR.0b013e3283491665 |
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| ispartof | Neuroreport, 2011-09, Vol.22 (13), p.629-632 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Cadherins - metabolism Cells, Cultured Dendritic Spines - metabolism Excitatory Postsynaptic Potentials - physiology Hippocampus - cytology Hippocampus - metabolism Hippocampus - physiology Miniature Postsynaptic Potentials - physiology Neurons - cytology Neurons - metabolism Neurons - physiology Rats Synapses - physiology |
| title | Type-II cadherins modulate neural activity in cultured rat hippocampal neurons |
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