Surfactant protein A (SP-A)-tacrolimus complexes have a greater anti-inflammatory effect than either SP-A or tacrolimus alone on human macrophage-like U937 cells

SP-A binds to FK506 with high affinity and strengthens tacrolimus potency as an anti-inflammatory agent on macrophages by facilitating FK506 entrance into the cell, overcoming P-glycoprotein. Intratracheal administration of immunosuppressive agents to the lung is a novel treatment after lung transpl...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2011-04, Vol.77 (3), p.384-391
Hauptverfasser:	López-Sánchez, Almudena, Sáenz, Alejandra, Casals, Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - metabolism Anti-Inflammatory Agents, Non-Steroidal - pharmacology ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Biological and medical sciences Cell Survival - drug effects Dose-Response Relationship, Drug Endocytosis - drug effects General pharmacology Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - metabolism Immunosuppressive Agents - pharmacology Inflammation Lipopolysaccharides - pharmacology Lung Macrophages Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Medical sciences Models, Molecular Molecular Structure P-glycoprotein Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Protein Binding Pulmonary Surfactant-Associated Protein A - administration & dosage Pulmonary Surfactant-Associated Protein A - metabolism Pulmonary Surfactant-Associated Protein A - pharmacology Receptors, Cell Surface - metabolism Surfactant protein A Tacrolimus Tacrolimus - administration & dosage Tacrolimus - metabolism Tacrolimus - pharmacology U937 Cells
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