Myoblast-mediated gene therapy via encephalomyosynangiosis – A novel strategy for local delivery of gene products to the brain surface

An encephalomyosynangiosis (EMS) is a temporal muscle graft that is placed onto the surface of the brain to serve as a source for collateral vessel growth for brain revascularization in patients with Moyamoya Disease (MMD). To facilitate an EMS in patients with occlusive cerebrovascular diseases oth...

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Veröffentlicht in:	Journal of neuroscience methods 2011-09, Vol.201 (1), p.61-66
Hauptverfasser:	Hecht, Nils, Peña-Tapia, Pablo, Vinci, Mara, von Degenfeld, Georges, Woitzik, Johannes, Vajkoczy, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - blood supply Brain - physiology Brain - surgery Cell Transplantation - trends Cerebral Revascularization - methods Chronic cerebral ischemia Encephalomyosynangiosis Gene Transfer Techniques - trends Genetic Therapy - trends Indirect Male Mice Mice, Inbred C57BL Moyamoya disease Moyamoya Disease - genetics Moyamoya Disease - therapy Myoblast-mediated gene therapy Myoblasts - physiology Myoblasts - transplantation Revascularization Temporal Muscle - physiology Temporal Muscle - transplantation
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