Pseudomonas aeruginosa infection in cystic fibrosis caused by an epidemic metallo-β-lactamase-producing clone with a heterogeneous carbapenem resistance phenotype
An epidemic IMP-13 metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa clone, causing infections and even large outbreaks in Italian critical care settings, was detected in a young cystic fibrosis patient. In this patient, the chronic infection was sustained by distinct clonal sub-populations...
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| Veröffentlicht in: | Clinical microbiology and infection 2011-08, Vol.17 (8), p.1272-1275 |
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| container_title | Clinical microbiology and infection |
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| creator | Pollini, S. Fiscarelli, E. Mugnaioli, C. Di Pilato, V. Ricciotti, G. Neri, A.S. Rossolini, G.M. |
| description | An epidemic IMP-13 metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa clone, causing infections and even large outbreaks in Italian critical care settings, was detected in a young cystic fibrosis patient. In this patient, the chronic infection was sustained by distinct clonal sub-populations of the MBL-producing P. aeruginosa clone, either susceptible or resistant to carbapenems. These findings underscore the importance of infection prevention practices in cystic fibrosis settings and pose an important diagnostic and therapeutic challenge. |
| doi_str_mv | 10.1111/j.1469-0691.2011.03466.x |
| format | Article |
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In this patient, the chronic infection was sustained by distinct clonal sub-populations of the MBL-producing P. aeruginosa clone, either susceptible or resistant to carbapenems. These findings underscore the importance of infection prevention practices in cystic fibrosis settings and pose an important diagnostic and therapeutic challenge.</description><identifier>ISSN: 1198-743X</identifier><identifier>EISSN: 1469-0691</identifier><identifier>DOI: 10.1111/j.1469-0691.2011.03466.x</identifier><identifier>PMID: 21375657</identifier><language>eng</language><publisher>Oxford, UK: Elsevier Ltd</publisher><subject>Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; beta-Lactam Resistance - genetics ; beta-Lactamases - biosynthesis ; beta-Lactamases - genetics ; Biological and medical sciences ; Carbapenems ; Carbapenems - pharmacology ; Child ; Chronic Disease ; Chronic infection ; Cystic fibrosis ; Cystic Fibrosis - epidemiology ; Cystic Fibrosis - microbiology ; Disease Outbreaks ; Electrophoresis, Gel, Pulsed-Field ; epidemic clone ; Epidemics ; Errors of metabolism ; Female ; Humans ; Infectious diseases ; Medical sciences ; Metabolic diseases ; Metallo- beta -lactamase ; metallo-β-lactamase ; Microbial Sensitivity Tests ; Miscellaneous hereditary metabolic disorders ; Pharmacology. Drug treatments ; Phenotype ; Pseudomonas aeruginosa ; Pseudomonas aeruginosa - classification ; Pseudomonas aeruginosa - enzymology ; Pseudomonas aeruginosa - genetics ; Pseudomonas aeruginosa - isolation & purification ; Pseudomonas Infections - epidemiology ; Pseudomonas Infections - microbiology</subject><ispartof>Clinical microbiology and infection, 2011-08, Vol.17 (8), p.1272-1275</ispartof><rights>2011 European Society of Clinical Infectious Diseases</rights><rights>2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases</rights><rights>2015 INIST-CNRS</rights><rights>2011 The Authors. 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In this patient, the chronic infection was sustained by distinct clonal sub-populations of the MBL-producing P. aeruginosa clone, either susceptible or resistant to carbapenems. These findings underscore the importance of infection prevention practices in cystic fibrosis settings and pose an important diagnostic and therapeutic challenge.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>beta-Lactam Resistance - genetics</subject><subject>beta-Lactamases - biosynthesis</subject><subject>beta-Lactamases - genetics</subject><subject>Biological and medical sciences</subject><subject>Carbapenems</subject><subject>Carbapenems - pharmacology</subject><subject>Child</subject><subject>Chronic Disease</subject><subject>Chronic infection</subject><subject>Cystic fibrosis</subject><subject>Cystic Fibrosis - epidemiology</subject><subject>Cystic Fibrosis - microbiology</subject><subject>Disease Outbreaks</subject><subject>Electrophoresis, Gel, Pulsed-Field</subject><subject>epidemic clone</subject><subject>Epidemics</subject><subject>Errors of metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metallo- beta -lactamase</subject><subject>metallo-β-lactamase</subject><subject>Microbial Sensitivity Tests</subject><subject>Miscellaneous hereditary metabolic disorders</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenotype</subject><subject>Pseudomonas aeruginosa</subject><subject>Pseudomonas aeruginosa - classification</subject><subject>Pseudomonas aeruginosa - enzymology</subject><subject>Pseudomonas aeruginosa - genetics</subject><subject>Pseudomonas aeruginosa - isolation & purification</subject><subject>Pseudomonas Infections - epidemiology</subject><subject>Pseudomonas Infections - microbiology</subject><issn>1198-743X</issn><issn>1469-0691</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUsFu1DAQjRCIlsIvIF8QpwQ7dpz4wAFWUJAWwQEkbpZjT3a9SuxgJ7T5Hv6gH8I34XSXciz2wWPNezPj95xliOCCpPXqUBDGRY65IEWJCSkwZZwX1w-y87vEwxQT0eQ1o9_PsicxHjDGJaXscXZWElpXvKrPs19fIszGD96piBSEeWedjwpZ14GerHcpQnqJk9Wos23w0Uak1RzBoHZByiEYrYEhpQeYVN_7_PdN3is9qUFFyMfgzayt2yHdewfoyk57pNAeJgh-Bw78vNYLrRrTZUABUoNJOQ1o3IPz0zLC0-xRp_oIz07nRfbt_buvmw_59vPlx82bba4rKnjedAAt4UZgU4kKuCork3QhohM1Z3UpurKlxrCGEc4EwwyLRgEBqhvV0hLTi-zlsW4a-scMcZKDjRr6Xt2OKQWuSdr4fmRTC4JL0rCEbI5InaSLATo5BjuosEiC5eqlPMjVMrlaJlcv5a2X8jpRn5-azO0A5o7417wEeHECqKhV34Ukm43_cIxWuOY84V4fcVe2h-W_B5Cb7ac1Svy3Rz4k8X9aCDJqC8kiY0P6JNJ4e_9r_gDlDtOm</recordid><startdate>201108</startdate><enddate>201108</enddate><creator>Pollini, S.</creator><creator>Fiscarelli, E.</creator><creator>Mugnaioli, C.</creator><creator>Di Pilato, V.</creator><creator>Ricciotti, G.</creator><creator>Neri, A.S.</creator><creator>Rossolini, G.M.</creator><general>Elsevier Ltd</general><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>201108</creationdate><title>Pseudomonas aeruginosa infection in cystic fibrosis caused by an epidemic metallo-β-lactamase-producing clone with a heterogeneous carbapenem resistance phenotype</title><author>Pollini, S. ; Fiscarelli, E. ; Mugnaioli, C. ; Di Pilato, V. ; Ricciotti, G. ; Neri, A.S. ; Rossolini, G.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5396-8feeb16d90d595e6a25d03419f9764729f2b3dd4841649404098ae1e3c8ab3203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial agents</topic><topic>Antibiotics. 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Antiparasitic agents</topic><topic>beta-Lactam Resistance - genetics</topic><topic>beta-Lactamases - biosynthesis</topic><topic>beta-Lactamases - genetics</topic><topic>Biological and medical sciences</topic><topic>Carbapenems</topic><topic>Carbapenems - pharmacology</topic><topic>Child</topic><topic>Chronic Disease</topic><topic>Chronic infection</topic><topic>Cystic fibrosis</topic><topic>Cystic Fibrosis - epidemiology</topic><topic>Cystic Fibrosis - microbiology</topic><topic>Disease Outbreaks</topic><topic>Electrophoresis, Gel, Pulsed-Field</topic><topic>epidemic clone</topic><topic>Epidemics</topic><topic>Errors of metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metallo- beta -lactamase</topic><topic>metallo-β-lactamase</topic><topic>Microbial Sensitivity Tests</topic><topic>Miscellaneous hereditary metabolic disorders</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenotype</topic><topic>Pseudomonas aeruginosa</topic><topic>Pseudomonas aeruginosa - classification</topic><topic>Pseudomonas aeruginosa - enzymology</topic><topic>Pseudomonas aeruginosa - genetics</topic><topic>Pseudomonas aeruginosa - isolation & purification</topic><topic>Pseudomonas Infections - epidemiology</topic><topic>Pseudomonas Infections - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pollini, S.</creatorcontrib><creatorcontrib>Fiscarelli, E.</creatorcontrib><creatorcontrib>Mugnaioli, C.</creatorcontrib><creatorcontrib>Di Pilato, V.</creatorcontrib><creatorcontrib>Ricciotti, G.</creatorcontrib><creatorcontrib>Neri, A.S.</creatorcontrib><creatorcontrib>Rossolini, G.M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Clinical microbiology and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pollini, S.</au><au>Fiscarelli, E.</au><au>Mugnaioli, C.</au><au>Di Pilato, V.</au><au>Ricciotti, G.</au><au>Neri, A.S.</au><au>Rossolini, G.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pseudomonas aeruginosa infection in cystic fibrosis caused by an epidemic metallo-β-lactamase-producing clone with a heterogeneous carbapenem resistance phenotype</atitle><jtitle>Clinical microbiology and infection</jtitle><addtitle>Clin Microbiol Infect</addtitle><date>2011-08</date><risdate>2011</risdate><volume>17</volume><issue>8</issue><spage>1272</spage><epage>1275</epage><pages>1272-1275</pages><issn>1198-743X</issn><eissn>1469-0691</eissn><abstract>An epidemic IMP-13 metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa clone, causing infections and even large outbreaks in Italian critical care settings, was detected in a young cystic fibrosis patient. 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| fulltext | fulltext |
| identifier | ISSN: 1198-743X |
| ispartof | Clinical microbiology and infection, 2011-08, Vol.17 (8), p.1272-1275 |
| issn | 1198-743X 1469-0691 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents beta-Lactam Resistance - genetics beta-Lactamases - biosynthesis beta-Lactamases - genetics Biological and medical sciences Carbapenems Carbapenems - pharmacology Child Chronic Disease Chronic infection Cystic fibrosis Cystic Fibrosis - epidemiology Cystic Fibrosis - microbiology Disease Outbreaks Electrophoresis, Gel, Pulsed-Field epidemic clone Epidemics Errors of metabolism Female Humans Infectious diseases Medical sciences Metabolic diseases Metallo- beta -lactamase metallo-β-lactamase Microbial Sensitivity Tests Miscellaneous hereditary metabolic disorders Pharmacology. Drug treatments Phenotype Pseudomonas aeruginosa Pseudomonas aeruginosa - classification Pseudomonas aeruginosa - enzymology Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - isolation & purification Pseudomonas Infections - epidemiology Pseudomonas Infections - microbiology |
| title | Pseudomonas aeruginosa infection in cystic fibrosis caused by an epidemic metallo-β-lactamase-producing clone with a heterogeneous carbapenem resistance phenotype |
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