Comparative analysis reveals selective recognition of glycans by the dendritic cell receptors DC-SIGN and Langerin

DC-SIGN (dendritic cell-specific ICAM-3 grabbing non-integrin) and Langerin are homologous C-type lectins expressed as cell-surface receptors on different populations of dendritic cells (DCs). DC-SIGN interacts with glycan structures on HIV-1, facilitating virus survival, transmission and infection,...

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Veröffentlicht in:	Protein engineering, design and selection design and selection, 2011-09, Vol.24 (9), p.659-669
Hauptverfasser:	Holla, Andrea, Skerra, Arne
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - chemistry Antigens, CD - genetics Antigens, CD - metabolism Binding Sites Calcium - metabolism Calorimetry Carbohydrate Sequence Cell Adhesion Molecules - chemistry Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Chromatography, Gel Dendritic Cells - cytology Dendritic Cells - metabolism Electrophoresis, Polyacrylamide Gel Fluorescent Dyes - chemistry Human immunodeficiency virus 1 Humans Lectins, C-Type - chemistry Lectins, C-Type - genetics Lectins, C-Type - metabolism Mannose - metabolism Mannose-Binding Lectins - chemistry Mannose-Binding Lectins - genetics Mannose-Binding Lectins - metabolism Microarray Analysis Polysaccharides - chemistry Polysaccharides - metabolism Protein Binding Receptors, Cell Surface - chemistry Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Recombinant Proteins Thermodynamics
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