Characterization of the kynurenine pathway in NSC‐34 cell line: implications for amyotrophic lateral sclerosis

J. Neurochem. (2011) 118, 816–825. Amyotrophic lateral sclerosis (ALS) is the most common type of motor neuron degenerative disease for which the aetiology is still unknown. The kynurenine pathway (KP) is a major degradative pathway of tryptophan ultimately leading to the production of NAD+ and is a...

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Veröffentlicht in:	Journal of neurochemistry 2011-09, Vol.118 (5), p.816-825
Hauptverfasser:	Chen, Yiquan, Brew, Bruce J., Guillemin, Gilles J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis Animals Antagonists Biological and medical sciences Brain Cell death Cell Line, Transformed Cerebrospinal fluid. Meninges. Spinal cord Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dose-Response Relationship, Drug Drug Interactions Enzymes Glutamic acid receptors (ionotropic) Hydrolases - metabolism Immune response Immunocytochemistry Interferon-gamma - pharmacology Iron Chelating Agents - pharmacology Kynurenic acid Kynurenine - metabolism kynurenine pathway L-Lactate dehydrogenase L-Lactate Dehydrogenase - metabolism Medical sciences memantine Metabolites Mice Microglia - drug effects Microglia - metabolism MK-801 motor neuron disease Motor neurons Motor Neurons - drug effects Motor Neurons - metabolism N-Methyl-D-aspartic acid receptors Nervous system (semeiology, syndromes) Neurochemistry Neurology Neurons neuroprotection Neuroprotective agents picolinic acid Picolinic Acids - pharmacology Polymerase chain reaction Quinolinic acid Signal transduction Signal Transduction - drug effects Signal Transduction - physiology Time Factors Toxicity Tryptophan Tryptophan - analogs & derivatives Tryptophan - pharmacology Tryptophan Oxygenase - metabolism
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